Regional Comprehensive Metabolomics Resource Cores (RCMRC)s
RCMRCs are expected to address the need for increasing metabolomics research capacity by providing national leadership in metabolomics research, training, and knowledge dissemination. As part of this endeavor, our RCMRCs provide services for metabolomics research via a Pilot and Feasibility Program.
| Michigan Regional Comprehensive Metabolomics Resource Core (MRC2) |
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| Mission Statement The Michigan Regional Comprehensive Metabolomics Research Core (MRC2) is an entity created to support, integrate and enhance basic and translational research incorporating metabolomics technology. |
| Areas of Expertise Consultations in targeted and untargeted metabolomics, study design to data analysis. Development and refinement of visualization tools for diverse data sets. Techniques to perform and analyze in vivo and in vitro fluxomics. |
| Services Consultations on topics from study design to data analysis, targeted and untargeted metabolomics, targeted and untargeted lipidomics, in vivo and in vitro fluxomics, statistics and data analysis, data visualization software. |
| Contact |
| West Coast Central Comprehensive Metabolomics Resource Core (WCMC) |
| Mission Statement The NIH West Coast Metabolomics Center extends metabolomics services to investigators in industry and academia while simultaneously advancing the state-of-the art in metabolomics technologies. |
| Areas of Expertise Databases, spectral libraries, mass spectrometry, quality-controlled high-throughput metabolomic data in epidemiology studies. Compound identification from untargeted metabolomics. Absolute quantification of target analytes. |
| Services Targeted and untargeted analysis of complex lipids, steroids, eicosanoids, oxylipins, primary metabolites, glycans and metabolic imaging. Pathway analysis and advanced statistics. Integration with genomic and proteomic data. |
| Contact |
| UNC Chapel Hill |
| Mission Statement The NIH Eastern RCMRC at UNC Chapel Hill partners with basic, clinical, and translational researchers to promote innovative research and provide training. |
| Areas of Expertise Broad spectrum and targeted metabolomics, metallomics, and mineralomics, using mass spectrometry and NMR Spectroscopy. Genomics, cell and animal research, epidemiology, statistics, and synthesis of isotopic labeled standards. |
| Services Metabolomics analysis of cells, organ tissues, fluids, and excreta. Statistical and multivariate analysis, pathway analysis, and integration of other clinical and genomics data streams via pathway or mQTL mapping. |
| Contact |
| Southeast Center for Integrated Metabolomics (SECIM) |
| Mission Statement The Southeast Center for Integrated Metabolomics provides state-of-the-art metabolomics services to users in all areas of biomedical, clinical and biological sciences using well defined and emerging technologies. |
| Areas of Expertise Liquid chromatography/mass spectrometry (LC/MS), Proton Nuclear Magnetic Resonance Spectroscopy (H- NMR) using high resolution magic angle spinning (HR-MAS), Imaging MS, Isotope Ratio Outlier Analysis (IROA), bioinformatics |
| Services Global and targeted analysis of various sample types including urine, cellular extracts from tissue culture, plasma/serum, and tissue specimens. Bio-statistical tools also available to aid in data interpretation. |
| Contact |
| Resource Center for Stable Isotope-Resolved Metabolomics (RC-SIRM) |
| Mission Statement The overall mission is to provide state-of-the art instrumentation, approaches, and interpretation for stable isotope-resolved metabolomics (SIRM), for basic-to-translational systems biochemistry. |
| Areas of Expertise SIRM involving integration of high information throughput (HIT) based on NMR and MS techniques. Direct experience expertise in human surgical studies, mice/xenografts, cell cultures, invertebrate, plant, & soil biochemistry. |
| Services Sample Core - full core-level attention to sample preparation; Analytical Core - 14.1T & 18.8T NMRs, FTMS (Orbitrap & ICR), GC & LC front ends, ICPMS; Informatics Core - HIT data reduction/interpretation of complex labeling. |
| Contact |
| Metabolomics Core at Mayo Clinic |
| Mission Statement The Mayo Clinic Metabolomics Resource Core integrates state-of-the-art metabolomics with phenotypic characteristics of disease or models of disease to advance understanding of the physiology and diseases, thereby facilitating rapid translation of basic discoveries into improved human health. |
| Areas of Expertise metabolic flux analysis, high-resolution high-throughput NMR spectroscopy, bioinformatics |
| Services Consultations, quantitative and qualitative large scale metabolomics analysis, measurement of stable isotope enrichment in metabolites, metabolic flux analysis, high-resolution high-throughput NMR spectroscopy, bioinformatics |
| Contact |
