Summary of Study ST000054
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000051. The data can be accessed directly via it's Project DOI: 10.21228/M8MS3J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000054 |
Study Title | Metabolic Microenvironments in Normal Breast and Breast Cancer (MS analysis) |
Study Type | Metabolomic analysis of normal breast tissue |
Study Summary | The purpose of this study was to understand the metabolomic changes in a breast tissue microenvironment at various stages of cancer development and progression (i.e. normal breast, DCIS, and invasive cancer). The goal of this metabolomics pilot and feasibility study was to apply a broad spectrum GC-MS metabolomics method to determine whether changes in normal tissue of women with cancer correlate with progression and or the subtype of the disease. |
Institute | University of North Carolina |
Department | Systems and Translational Sciences |
Laboratory | Sumner Lab |
Last Name | Sumner |
First Name | Susan |
Address | Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081 |
susan_sumner @unc.edu | |
Phone | 704-250-5066 |
Submit Date | 2014-04-30 |
Num Groups | 8 |
Total Subjects | 192 |
Study Comments | sample preparation and analysis randomized with data collection over multiple days |
Publications | 1. Brauer HA, Makowski L, Hoadley KA, Casbas-Hernandez P, Lang LJ, Roman-Perez E, D’Arcy M, Freemerman AJ, Perou CM, Troester MA: Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer. Clin Cancer Res 2012;19:571-585. 2. J Budczies, C Denkert, B Muller, S Brockmoller, F Klauschen, B Gyorffy, M Dietel, C Richter-Ehrenstein, U Marten, R Salek, J Griffin, M Hilvo, M Oresic, G Wohlgemuth, O Fiehn: Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue – a GC-TOFMS based metabolomics study. BMC Genomics 2012; 13:334. |
Raw Data Available | Yes |
Raw Data File Type(s) | cdf |
Uploaded File Size | 8.4 G |
Analysis Type Detail | GC-MS |
Release Date | 2018-08-27 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
Project ID: | PR000051 |
Project DOI: | doi: 10.21228/M8MS3J |
Project Title: | Metabolic Microenvironments in Normal Breast and Breast Cancer |
Project Type: | Broad Spectrum |
Project Summary: | Breast cancers evolve and acquire adaptive changes while in active communication with the surrounding host normal tissue. It is important to understand the genomic and metabolomic changes in breast microenvironment at various stages of cancer development and progression (i.e., normal breast, DCIS, benign disease and invasive cancer). Since intrinsic breast cancer subtypes are very distinct from each other in terms of clinical features as well as the genomic profiling, these subtypes may also have distinct metabolic microenvironment signatures. |
Institute: | University of North Carolina at Chapel Hill |
Department: | Epidemiology |
Laboratory: | Troester Laboratory |
Last Name: | Troester |
First Name: | Melissa |
Address: | University of North Carolina at Chapel Hill Chapel Hill, NC 27599 |
Email: | troester@unc.edu |
Phone: | 919-966-7408 |