Summary of Study ST000054
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000051. The data can be accessed directly via it's Project DOI: 10.21228/M8MS3J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000054 |
Study Title | Metabolic Microenvironments in Normal Breast and Breast Cancer (MS analysis) |
Study Type | Metabolomic analysis of normal breast tissue |
Study Summary | The purpose of this study was to understand the metabolomic changes in a breast tissue microenvironment at various stages of cancer development and progression (i.e. normal breast, DCIS, and invasive cancer). The goal of this metabolomics pilot and feasibility study was to apply a broad spectrum GC-MS metabolomics method to determine whether changes in normal tissue of women with cancer correlate with progression and or the subtype of the disease. |
Institute | University of North Carolina |
Department | Systems and Translational Sciences |
Laboratory | Sumner Lab |
Last Name | Sumner |
First Name | Susan |
Address | Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081 |
susan_sumner @unc.edu | |
Phone | 704-250-5066 |
Submit Date | 2014-04-30 |
Num Groups | 8 |
Total Subjects | 192 |
Study Comments | sample preparation and analysis randomized with data collection over multiple days |
Publications | 1. Brauer HA, Makowski L, Hoadley KA, Casbas-Hernandez P, Lang LJ, Roman-Perez E, D’Arcy M, Freemerman AJ, Perou CM, Troester MA: Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer. Clin Cancer Res 2012;19:571-585. 2. J Budczies, C Denkert, B Muller, S Brockmoller, F Klauschen, B Gyorffy, M Dietel, C Richter-Ehrenstein, U Marten, R Salek, J Griffin, M Hilvo, M Oresic, G Wohlgemuth, O Fiehn: Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue – a GC-TOFMS based metabolomics study. BMC Genomics 2012; 13:334. |
Raw Data Available | Yes |
Raw Data File Type(s) | cdf |
Uploaded File Size | 8.4 G |
Analysis Type Detail | GC-MS |
Release Date | 2018-08-27 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR000074 |
Treatment Summary: | Stages of breast cancer progression and different subtypes compared to a non-malignant control |
Treatment Protocol Comments: | DCIS, Luminal A, Luminal B, HER2, Basal, Reduction, Total Pool1 (equal mix of DCIS, HER2, LumA, LumB, Reduction, and Basal pool samples),Total Pool2 (unequal mix of DCIS, HER2, LumA, LumB, Reduction, and Basal pool samples) |