Summary of Study ST002500
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001614. The data can be accessed directly via it's Project DOI: 10.21228/M82T5P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002500 |
| Study Title | Plasma metabolomic signatures from patients following high-dose total body irradiation |
| Study Summary | Although some progress has been made in the study of radiation injury, there are still no effective prevention and treatment methods for severe acute radiation syndrome or sickness (ARS). Accordingly, a thorough understanding of biological characteristics associated with high-dose radiation is essential for revealing the mechanisms underlying the varied biological processes following high dose radiation and the development of novel potent radioprotective agents. In present study, plasma metabolic characteristics were investigated from patients of hematopoietic stem cell transplantation following high-dose TBI pretreatment utilizing gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). The most potential panel of four metabolic markers for radiation injury was selected and the metabolic disorders involved were explored. The metabolic disorders implied the dysregulation of gut microflora, shift of energy supply from aerobic respiration to ketogenesis, protein synthesis and metabolism in response to TBI. Although similar metabolic alternation patterns exist between male and female following high-dose irradiation, specific changes are observed in either male or female patients. These findings provide valuable information for further selecting biomarkers, clues of pathogenic mechanisms involved in high-dose radiation exposure. |
| Institute | Soochow University |
| Last Name | Wang |
| First Name | Chang |
| Address | Suzhou, No. 199, Renai Road, Suzhou Industrial Park |
| wangchang@suda.edu.cn | |
| Phone | +8651265880067 |
| Submit Date | 2023-02-27 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | cdf, raw(Thermo) |
| Analysis Type Detail | GC-MS/LC-MS |
| Release Date | 2024-02-28 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO002590 |
| Collection Summary: | whole blood was collected prior to irradiation (3 days before the first dose of TBI) and at approximately 72h after the end of radiation. |
| Sample Type: | Blood (whole) |
