Summary of Study ST002980
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001856. The data can be accessed directly via it's Project DOI: 10.21228/M8T42G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002980 |
Study Title | Water soluble metabolomics in mice upon loss of SHMT |
Study Summary | The enzyme SHMT interconverts the amino acids serine and glycine as part of the folate cycle. To explore the role of SHMT in amino acid homeostasis, Mice were treated with a small molecule inhibitor of SHMT (SHIN2) or had Shmt2 genetically knocked-out in a liver specific manner. Serum and liver samples were collected and underwent LC-MS metabolomics analysis. |
Institute | Princeton University |
Last Name | McBride |
First Name | Matthew |
Address | Carl Icahn Lab, South Drive, Princeton, NJ 08544 |
matthewmcbride@princeton.edu | |
Phone | 8567457389 |
Submit Date | 2023-11-14 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzXML |
Analysis Type Detail | LC-MS |
Release Date | 2023-12-12 |
Release Version | 1 |
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Collection:
Collection ID: | CO003086 |
Collection Summary: | For pharmacological inhibition of SHMT, mice were treated with Vehicle or SHIN2 for 12 hours and then blood serum and liver samples were collected. For genetic loss of Shmt2, blood serum and liver samples were collected from mice 21 days after liver-specific gene knockout. |
Sample Type: | Blood (serum) and Liver |