Summary of Study ST002980

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001856. The data can be accessed directly via it's Project DOI: 10.21228/M8T42G This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002980
Study TitleWater soluble metabolomics in mice upon loss of SHMT
Study SummaryThe enzyme SHMT interconverts the amino acids serine and glycine as part of the folate cycle. To explore the role of SHMT in amino acid homeostasis, Mice were treated with a small molecule inhibitor of SHMT (SHIN2) or had Shmt2 genetically knocked-out in a liver specific manner. Serum and liver samples were collected and underwent LC-MS metabolomics analysis.
Institute
Princeton University
Last NameMcBride
First NameMatthew
AddressCarl Icahn Lab, South Drive, Princeton, NJ 08544
Emailmatthewmcbride@princeton.edu
Phone8567457389
Submit Date2023-11-14
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailLC-MS
Release Date2023-12-12
Release Version1
Matthew McBride Matthew McBride
https://dx.doi.org/10.21228/M8T42G
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Sample type Genotype Treatment
SA323395SHMT2flox_KO_22_liverLiver Liver KO None
SA323396SHMT2flox_KO_23_liverLiver Liver KO None
SA323397SHMT2flox_KO_21_liverLiver Liver KO None
SA323398SHMT2flox_KO_35_liverLiver Liver KO None
SA323399SHMT2flox_KO_43_liverLiver Liver KO None
SA323400SHMT2flox_KO_45_liverLiver Liver KO None
SA323401SHMT2flox_KO_44_liverLiver Liver KO None
SA323402SHMT2flox_WT_46_liverLiver Wild-type None
SA323403SHMT2flox_WT_15_liverLiver Wild-type None
SA323404SHMT2flox_WT_20_liverLiver Wild-type None
SA323405SHMT2flox_WT_34_liverLiver Wild-type None
SA323406SHMT2flox_WT_37_liverLiver Wild-type None
SA323407SHIN2_2_liverLiver Wild-type SHIN2
SA323408SHIN2_3_liverLiver Wild-type SHIN2
SA323409SHIN2_1_liverLiver Wild-type SHIN2
SA323410Veh_1_liverLiver Wild-type Vehicle
SA323411Veh_2_liverLiver Wild-type Vehicle
SA323412Veh_3_liverLiver Wild-type Vehicle
SA323413SHMT2flox_KO_45_serumSerum Liver KO None
SA323414SHMT2flox_KO_44_serumSerum Liver KO None
SA323415SHMT2flox_KO_22_serumSerum Liver KO None
SA323416SHMT2flox_KO_21_serumSerum Liver KO None
SA323417SHMT2flox_KO_43_serumSerum Liver KO None
SA323418SHMT2flox_KO_23_serumSerum Liver KO None
SA323419SHMT2flox_KO_35_serumSerum Liver KO None
SA323420SHMT2flox_WT_20_serumSerum Wild-type None
SA323421SHMT2flox_WT_15_serumSerum Wild-type None
SA323422SHMT2flox_WT_34_serumSerum Wild-type None
SA323423SHMT2flox_WT_37_serumSerum Wild-type None
SA323424SHMT2flox_WT_46_serumSerum Wild-type None
SA323425SHIN2_2_serumSerum Wild-type SHIN2
SA323426SHIN2_1_serumSerum Wild-type SHIN2
SA323427SHIN2_3_serumSerum Wild-type SHIN2
SA323428Veh_2_serumSerum Wild-type Vehicle
SA323429Veh_3_serumSerum Wild-type Vehicle
SA323430Veh_1_serumSerum Wild-type Vehicle
Showing results 1 to 36 of 36
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