Summary of Study ST002558

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001650. The data can be accessed directly via it's Project DOI: 10.21228/M8DX4F This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002558
Study TitleExtraction and Untargeted Analysis of Metabolome from Undemineralised Cortical Bone Matrix for Forensic Application
Study SummaryUntargeted metabolomics has become the gold standard for the profiling of low-molecular-weight compounds. Recently, metabolomics has shown great potential in forensic science in the field of toxicology and postmortem interval estimation. The current study aims to evaluate three extraction protocol and four liquid chromatography coupled with mass spectrometry assays that could offer a valuable tool to identify biomarkers for PMI estimation. One fragment for anterior human skeletal tibia from a 82 years old male individual belonging to the Forensic Anthropology Center - Texas State University collection was powdered and extracted in five replicates to be extracted according to a the biphasic chloroform/methanol/water protocol and two single phase protocols based on methanol/water and methanol/acetonitrile/water. Formal analysis was carried out ThermoFisher Ultimate 3000 HPLC in hydrophilic interaction (HILIC) and reverse phase (RP) liquid chromatography coupled with SCIEX 6600 TripleTOF Q-TOF mass spectrometer.
Institute
University of Central Lancashire
DepartmentNatural Sciences
Last NameBonicelli
First NameAndrea
Address1 North Cliff street
Emailabonicelli@uclan.ac.uk
Phone07383974949
Submit Date2023-03-15
Num Groups3
Total Subjects1
Num Males1
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-03-17
Release Version1
Andrea Bonicelli Andrea Bonicelli
https://dx.doi.org/10.21228/M8DX4F
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id class type
SA257238BLK B_RP_posBlank Blank
SA257239BLK C_Hilic_posBlank Blank
SA257240BLK B_Hilic_posBlank Blank
SA257241BLK A_RP_posBlank Blank
SA257242BLK C_Hilic_negBlank Blank
SA257243BLK A_Hilic_negBlank Blank
SA257244BLK B_Hilic_negBlank Blank
SA257245BLK A_Hilic_posBlank Blank
SA257246BLK C_RP_posBlank Blank
SA257247BLK A_RP_negBlank Blank
SA257248BLK C_RP_negBlank Blank
SA257249BLK B_RP_negBlank Blank
SA257250A1_Hilic_posChlor_Meth Sample
SA257251A5_Hilic_negChlor_Meth Sample
SA257252A3_Hilic_negChlor_Meth Sample
SA257253A4_Hilic_negChlor_Meth Sample
SA257254A2_RP_posChlor_Meth Sample
SA257255A3_RP_posChlor_Meth Sample
SA257256A2_Hilic_negChlor_Meth Sample
SA257257A3_RP_negChlor_Meth Sample
SA257258A2_RP_negChlor_Meth Sample
SA257259A4_RP_negChlor_Meth Sample
SA257260A5_RP_negChlor_Meth Sample
SA257261A4_RP_posChlor_Meth Sample
SA257262A5_RP_posChlor_Meth Sample
SA257263A1_RP_negChlor_Meth Sample
SA257264A1_RP_posChlor_Meth Sample
SA257265A4_Hilic_posChlor_Meth Sample
SA257266A1_Hilic_negChlor_Meth Sample
SA257267A3_Hilic_posChlor_Meth Sample
SA257268A5_Hilic_posChlor_Meth Sample
SA257269A2_Hilic_posChlor_Meth Sample
SA257270C1_RP_posMeth_ACN Sample
SA257271C1_Hilic_posMeth_ACN Sample
SA257272C2_Hilic_posMeth_ACN Sample
SA257273C4_Hilic_posMeth_ACN Sample
SA257274C3_Hilic_posMeth_ACN Sample
SA257275C3_RP_posMeth_ACN Sample
SA257276C4_RP_posMeth_ACN Sample
SA257277C1_RP_negMeth_ACN Sample
SA257278C2_RP_negMeth_ACN Sample
SA257279C4_RP_negMeth_ACN Sample
SA257280C5_RP_negMeth_ACN Sample
SA257281C5_RP_posMeth_ACN Sample
SA257282C5_Hilic_posMeth_ACN Sample
SA257283C3_RP_negMeth_ACN Sample
SA257284C2_RP_posMeth_ACN Sample
SA257285C4_Hilic_negMeth_ACN Sample
SA257286C2_Hilic_negMeth_ACN Sample
SA257287C1_Hilic_negMeth_ACN Sample
SA257288C5_Hilic_negMeth_ACN Sample
SA257289C3_Hilic_negMeth_ACN Sample
SA257290B5_RP_negMeth_Water Sample
SA257291B4_RP_negMeth_Water Sample
SA257292B3_RP_negMeth_Water Sample
SA257293B5_Hilic_posMeth_Water Sample
SA257294B1_Hilic_negMeth_Water Sample
SA257295B2_Hilic_negMeth_Water Sample
SA257296B5_Hilic_negMeth_Water Sample
SA257297B4_Hilic_negMeth_Water Sample
SA257298B3_Hilic_negMeth_Water Sample
SA257299B4_Hilic_posMeth_Water Sample
SA257300B3_Hilic_posMeth_Water Sample
SA257301B1_RP_posMeth_Water Sample
SA257302B1_Hilic_posMeth_Water Sample
SA257303B1_RP_negMeth_Water Sample
SA257304B2_RP_negMeth_Water Sample
SA257305B2_RP_posMeth_Water Sample
SA257306B3_RP_posMeth_Water Sample
SA257307B2_Hilic_posMeth_Water Sample
SA257308B5_RP_posMeth_Water Sample
SA257309B4_RP_posMeth_Water Sample
SA257310QC05_Hilic_posQC QC
SA257311QC08_Hilic_posQC QC
SA257312QC01_RP_negQC QC
SA257313QC02_RP_negQC QC
SA257314QC03_RP_negQC QC
SA257315QC04_RP_negQC QC
SA257316QC07_Hilic_posQC QC
SA257317QC06_RP_negQC QC
SA257318QC05_RP_negQC QC
SA257319QC08_RP_negQC QC
SA257320QC07_RP_negQC QC
SA257321QC06_Hilic_posQC QC
SA257322QC07_RP_posQC QC
SA257323QC01_Hilic_posQC QC
SA257324QC04_Hilic_negQC QC
SA257325QC03_Hilic_negQC QC
SA257326QC02_Hilic_posQC QC
SA257327QC03_Hilic_posQC QC
SA257328QC06_Hilic_negQC QC
SA257329QC07_Hilic_negQC QC
SA257330QC08_Hilic_negQC QC
SA257331QC02_Hilic_negQC QC
SA257332QC01_Hilic_negQC QC
SA257333QC05_RP_posQC QC
SA257334QC06_RP_posQC QC
SA257335QC05_Hilic_negQC QC
SA257336QC04_RP_posQC QC
SA257337QC03_RP_posQC QC
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