Summary of Study ST003103

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001926. The data can be accessed directly via it's Project DOI: 10.21228/M8RT5W This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003103
Study TitleReinforcing the Evidence of Mitochondrial Dysfunction in Long COVID Patients using a Multiplatform Mass Spectrometry-based Metabolomics Approach
Study SummaryDespite the recent and increasing knowledge surrounding COVID-19 infection, the underlying mechanisms of the persistence of symptoms long time after the acute infection are still not completely understood. Here, a multiplatform mass spectrometry-based approach was used for metabolomic and lipidomic profiling of human plasma samples from Long COVID patients (n=40) to reveal mitochondrial dysfunction when compared with individuals fully recovered from acute mild COVID-19 (n=40). Untargeted metabolomic analysis using CE-ESI(+/–)-TOF-MS and GC-Q-MS was performed. Additionally, a lipidomic analysis using LC-ESI(+/–)-QTOF-MS based on an in-house library revealed 471 lipid species identified with high confidence annotation level. The integration of complementary analytical platforms has allowed a comprehensive metabolic and lipidomic characterization of plasma alterations in Long COVID disease that found 46 relevant metabolites which allowed to discriminate between Long COVID and fully recovered patients. We report specific metabolites altered in Long COVID, mainly related to a decrease in the amino acid metabolism and ceramide plasma levels, and an increase in the tricarboxylic acid (TCA) cycle, reinforcing the evidence of an impaired mitochondrial function. The most relevant alterations shown in this study will help to better understand the insights of Long COVID syndrome by providing a deeper knowledge of the metabolomic basis of the pathology.
Institute
Universidad CEU San Pablo
DepartmentChemistry and Biochemistry
LaboratoryCEMBIO
Last NameMartinez
First NameSara
AddressUrbanización Montepríncipe, 28660, Boadilla del Monte, Madrid, Spain
Emailsara.martinezlopez@ceu.es
Phone(+34)913724769
Submit Date2024-02-15
Num Groups2
Total Subjects80
Num Males14
Num Females66
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailGC/LC-MS
Release Date2024-03-25
Release Version1
Sara Martinez Sara Martinez
https://dx.doi.org/10.21228/M8RT5W
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Factor
SA333503L52Plasma Long COVID
SA333504L51Plasma Long COVID
SA333505L50Plasma Long COVID
SA333506L54Plasma Long COVID
SA333507L56Plasma Long COVID
SA333508L58Plasma Long COVID
SA333509L57Plasma Long COVID
SA333510L49Plasma Long COVID
SA333511L55Plasma Long COVID
SA333512L47Plasma Long COVID
SA333513L103Plasma Long COVID
SA333514L102Plasma Long COVID
SA333515L101Plasma Long COVID
SA333516L42Plasma Long COVID
SA333517L43Plasma Long COVID
SA333518L59Plasma Long COVID
SA333519L46Plasma Long COVID
SA333520L45Plasma Long COVID
SA333521L48Plasma Long COVID
SA333522L61Plasma Long COVID
SA333523L74Plasma Long COVID
SA333524L73Plasma Long COVID
SA333525L72Plasma Long COVID
SA333526L75Plasma Long COVID
SA333527L76Plasma Long COVID
SA333528L79Plasma Long COVID
SA333529L78Plasma Long COVID
SA333530L77Plasma Long COVID
SA333531L70Plasma Long COVID
SA333532L69Plasma Long COVID
SA333533L63Plasma Long COVID
SA333534L62Plasma Long COVID
SA333535L100Plasma Long COVID
SA333536L64Plasma Long COVID
SA333537L65Plasma Long COVID
SA333538L68Plasma Long COVID
SA333539L67Plasma Long COVID
SA333540L66Plasma Long COVID
SA333541L60Plasma Long COVID
SA333542L44Plasma Long COVID
SA333543QC2Plasma Quality control
SA333544QC3Plasma Quality control
SA333545QC12Plasma Quality control
SA333546QC11Plasma Quality control
SA333547QC1Plasma Quality control
SA333548QC4Plasma Quality control
SA333549QC10Plasma Quality control
SA333550QC5Plasma Quality control
SA333551QC9Plasma Quality control
SA333552QC8Plasma Quality control
SA333553QC6Plasma Quality control
SA333554QC7Plasma Quality control
SA333555C18Plasma Recovered from acute COVID-19
SA333556C17Plasma Recovered from acute COVID-19
SA333557C19Plasma Recovered from acute COVID-19
SA333558C21Plasma Recovered from acute COVID-19
SA333559C16Plasma Recovered from acute COVID-19
SA333560C20Plasma Recovered from acute COVID-19
SA333561C2Plasma Recovered from acute COVID-19
SA333562C13Plasma Recovered from acute COVID-19
SA333563C10Plasma Recovered from acute COVID-19
SA333564C22Plasma Recovered from acute COVID-19
SA333565C11Plasma Recovered from acute COVID-19
SA333566C12Plasma Recovered from acute COVID-19
SA333567C14Plasma Recovered from acute COVID-19
SA333568C15Plasma Recovered from acute COVID-19
SA333569C23Plasma Recovered from acute COVID-19
SA333570C52Plasma Recovered from acute COVID-19
SA333571C55Plasma Recovered from acute COVID-19
SA333572C49Plasma Recovered from acute COVID-19
SA333573C43Plasma Recovered from acute COVID-19
SA333574C42Plasma Recovered from acute COVID-19
SA333575C59Plasma Recovered from acute COVID-19
SA333576C1Plasma Recovered from acute COVID-19
SA333577C8Plasma Recovered from acute COVID-19
SA333578C7Plasma Recovered from acute COVID-19
SA333579C68Plasma Recovered from acute COVID-19
SA333580C61Plasma Recovered from acute COVID-19
SA333581C41Plasma Recovered from acute COVID-19
SA333582C4Plasma Recovered from acute COVID-19
SA333583C27Plasma Recovered from acute COVID-19
SA333584C29Plasma Recovered from acute COVID-19
SA333585C26Plasma Recovered from acute COVID-19
SA333586C25Plasma Recovered from acute COVID-19
SA333587C24Plasma Recovered from acute COVID-19
SA333588C31Plasma Recovered from acute COVID-19
SA333589C32Plasma Recovered from acute COVID-19
SA333590C37Plasma Recovered from acute COVID-19
SA333591C35Plasma Recovered from acute COVID-19
SA333592C34Plasma Recovered from acute COVID-19
SA333593C33Plasma Recovered from acute COVID-19
SA333594C9Plasma Recovered from acute COVID-19
Showing results 1 to 92 of 92
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