NIH Common Fund Metabolomics Funded Research

Projects funded since the inception of this program can be found at https://commonfund.nih.gov/Metabolomics/fundedresearch

Pilot and Feasibility Program

Pilot and Feasibility P&F awards are intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research, and to support projects that will provide preliminary data for new extramural proposal submission.

Please see our Pilot and Feasibility Program page for a list of funded Pilot and Feasibility studies.

Comprehensive Metabolomics Resource Cores

Goal: To create National Comprehensive Metabolomics Resource Cores, expanding on existing nationally funded metabolomics resources.

Regional Comprehensive Metabolomics Resource Cores (RCMRC) (U24) RFA-RM-11-016
PI Name	Institution Name	Title
Burant, Charles F	University of Michigan at Ann Arbor	Michigan Regional Comprehensive Metabolomics Resource Core (MRC2)
Fiehn, Oliver	University of California Davis	West Coast Central Comprehensive Metabolomics Resource Core (WCMC)
Sumner, Susan J	Research Triangle Institute	RTI's Regional Comprehensive Metabolomics Resource Center
Edison, Arthur S (contact) Yost, Richard A.	University of Florida	Southeast Resource Center for Integrated Metabolomics (SECIM)
Higashi, Richard M (contact) Fan, Teresa W-M Lane, Andrew N Moseley, Hunter Nathaniel	University of Kentucky	Resource Center for Stable Isotope-Resolved Metabolomics
Nair, K Sreekumaran	Mayo Clinic	Mayo Clinic Metabolomics Resource Core

Training in Metabolomics

Goal: To increase the number of investigators with metabolomics expertise by supporting interdisciplinary training involving a diverse set of training vehicles that match career stage and goals.

Development of Courses or Workshops in Metabolomics (R25) RFA-RM-11-018
PI Name	Institution Name	Title
Barnes, Stephen	University of Alabama at Birmingham	UAB Metabolomics Workshop: from design to decision
Kohlmeier, Martin	University of North Carolina Chapel Hill	Online learning platform: introducing clinicians and researchers to metabolomics
Mentored Research Scientist Development Award in Metabolomics (K01) RFA-RM-11-017
PI Name	Institution Name	Title
Ammons, Mary Cloud Bosworth	Montana State University - Bozeman	Metabolomic Analysis as a Tool to Understanding the Use of Novel Therapeutics in
Ngo, Debby	Massachusetts General Hospital	The Kynurenine Pathway in Pulmonary Arterial Hypertension
Phelan, Vanessa V	University of California San Diego	The Interactive Metabolome of Polymicrobial Biofilms
Rowley, Jesse	University of Utah	The Platelet Metabolome in Obesity
Mentored Research Scientist Development Award in Metabolomics (K01) RFA-RM-12-025
PI Name	Institution Name	Title
Gooding, Jessica	Duke University	Metabolic Regulators of Insulin Secretion and Insulin Resistance
Grossmann, Ruth Elizabeth	University of Iowa	Metabolomic Biomarkers of a Nutritional Intervention to Prevent Weight Gain
Mitsche, Matthew Alvin	UT Southwestern Medical Center	Determining the Function of PNPLA3 Utilizing Metabolomics and Stable Isotope Labe
Theriot, Casey	University of Michigan	Shifts in the Gastrointestinal Metabolome During Clostridium difficile Infection
Viader, Andreu	Scripps Research Institute	Lipidomic mapping of the cellular anatomy of brain endocannabinoid metabolism
Yim, Sun Hee	Brigham and Women's Hospital	Metabolomics of Aging

Metabolomics Technology Development

Goal: To address current limitations in metabolomics technologies so they can be easily adapted by other laboratories.

Technology Development to Enable Large Scale Metabolomics Analyses (R01) RFA-RM-11-019
PI Name	Institution Name	Title
Baker, Erin S	Battelle Pacific Northwest Laboratories	Platform Providing Increased Throughput, Sensitivity and Specificity for Metabolo
Fan, Teresa W-M (contact) Higashi, Richard M Moseley, Hunter Nathaniel Nantz, Michael H	University of Louisville	Integrated Chemoselective and Informatic Platform for Large-Scale Metabolomics
Hu, Jian Zhi	Battelle Pacific Northwest Laboratories	Slow-MAS NMR Metabolomics
Murphy, Robert Carl	University of Colorado Denver	High Throughput Lipidomics Analysis by MALDI/Ion Mobility Mass Spectrometry
Patterson, Andrew	Pennsylvania State University-UNIV Park	Optimized Metabolite Extraction, Separation, and Identification for Metabolomics
Patti, Gary Joseph	Washington University	Developing the Untargeted Metabolomic Workflow for High-Throughput Analyses

Metabolomics Reference Standards Synthesis

Goal: To increase the repertoire of chemically identifiable metabolites through the synthesis of reliable metabolic standards.

Synthesis contracts have been awarded to RTI International and SRI International and synthesis pilot studies with select metabolites are underway.

Data Sharing and International Collaboration

Data sharing and international collaboration are important aspects of the Metabolomics Research Capacity program, and will be accomplished via the Metabolomics Workbench.

Metabolomics Data Repository and Coordinating Center (U01) RFA-RM-11-020
PI Name	Institution Name	Title
Subramaniam, Shankar	University of California San Diego	The Metabolomics Data Center and Workbench (MDCW)

Administrative Supplement Program

Since 2012, the NIH has issued an annual solicitation for Administrative Supplements to existing NIH grants to form new interactive collaborations between basic or clinical researchers and metabolomics experts to add a metabolomics approach to the existing Research Strategy for the project. In addition to enhancing the parent grant by adding metabolomics analyses, collaborative projects include activities to increase the expertise of the biomedical research group in key aspects of metabolomics study design, analysis, and data interpretation. Funded projects can be found at https://commonfund.nih.gov/Metabolomics/fundedresearch