Human Metabolome Gene/Protein Database (MGP)

Introduction
The Human Metabolome Gene/Protein Database (MGP) of metabolome-related genes and proteins contains data for over 7300 genes and over 15,500 proteins.

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MGP_ID Entrez Gene_ID Gene Name Gene Symbol Synonyms Alternate names HMDB Pathway Abciximab Action Pathway Acebutolol Action Pathway Acetaminophen Metabolism Pathway Adefovir Dipivoxil Metabolism Pathway Alanine Metabolism Alpha Linolenic Acid and Linoleic Acid Metabolism Amino Sugar Metabolism Ammonia Recycling Androgen and Estrogen Metabolism Arachidonic Acid Metabolism Arginine and Proline Metabolism Aspartate Metabolism Azathioprine Action Pathway Benazepril Action Pathway Benzocaine Action Pathway Beta Oxidation of Very Long Chain Fatty Acids Beta-Alanine Metabolism Betaine Metabolism Bevacizumab Action Pathway Bile Acid Biosynthesis Biotin Metabolism Butyrate Metabolism Caffeine Metabolism Carnitine Synthesis Carvedilol Action Pathway Catecholamine Biosynthesis Celecoxib Action Pathway Citalopram Action Pathway Citric Acid Cycle Clopidogrel Action Pathway Corticotropin Activation of Cortisol Production Cyclophosphamide Action Pathway Cysteine Metabolism Degradation of Superoxides Dopamine Activation of Neurological Reward System Doxorubicin Metabolism Pathway Enoxaparin Action Pathway Erlotinib Action Pathway Esomeprazole Action Pathway Ethanol Degradation Etoposide Action Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Fatty Acid Biosynthesis Fatty Acid Elongation In Mitochondria Fatty acid Metabolism Fc Epsilon Receptor I Signaling in Mast Cells Folate Metabolism Fructose and Mannose Degradation Galactose Metabolism Gemcitabine Action Pathway Gluconeogenesis Glucose-Alanine Cycle Glutamate Metabolism Glutathione Metabolism Glycerol Phosphate Shuttle Glycerolipid Metabolism Glycine and Serine Metabolism Glycolysis Histidine Metabolism Ibuprofen Action Pathway Indomethacin Action Pathway Inositol Metabolism Inositol Phosphate Metabolism Insulin Signalling Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Irinotecan Action Pathway Ketone Body Metabolism Kidney Function Lactose Degradation Lactose Synthesis Lamivudine Metabolism Pathway Leucine Stimulation on Insulin Signaling Lysine Degradation Malate-Aspartate Shuttle Methionine Metabolism Mitochondrial Electron Transport Chain Morphine Action Pathway Mycophenolic Acid Metabolism Pathway Nalbuphine Action Pathway Nateglinide Action Pathway Nicotinate and Nicotinamide Metabolism Nicotine Action Pathway Nucleotide Excision Repair Nucleotide Sugars Metabolism Oxidation of Branched Chain Fatty Acids Paclitaxel Action Pathway Pantothenate and CoA Biosynthesis Pentose Phosphate Pathway Phenylacetate Metabolism Phenylalanine and Tyrosine Metabolism Phenytoin (Antiarrhythmic) Action Pathway Phosphatidylinositol Phosphate Metabolism Phospholipid Biosynthesis Phytanic Acid Peroxisomal Oxidation Plasmalogen Synthesis Porphyrin Metabolism Prednisolone Action Pathway Propanoate Metabolism Pterine Biosynthesis Purine Metabolism Pyrimidine Metabolism Pyruvaldehyde Degradation Pyruvate Metabolism Retinol Metabolism Riboflavin Metabolism Selenoamino Acid Metabolism Spermidine and Spermine Biosynthesis Sphingolipid Metabolism Starch and Sucrose Metabolism Steroid Biosynthesis Steroidogenesis Sulfate/Sulfite Metabolism Tamoxifen Action Pathway Taurine and Hypotaurine Metabolism Thiamine Metabolism Thyroid hormone synthesis Tramadol Metabolism Pathway Transfer of Acetyl Groups into Mitochondria Trehalose Degradation Tryptophan Metabolism Tyrosine Metabolism Ubiquinone Biosynthesis Urea Cycle Valine, Leucine and Isoleucine Degradation" Valproic Acid Metabolism Pathway Vasopressin Regulation of Water Homeostasis Vinblastine Action Pathway Vitamin B6 Metabolism Vitamin K Metabolism Warburg Effect Reactome Pathway 5-Phosphoribose 1-diphosphate biosynthesis A tetrasaccharide linker sequence is required for GAG synthesis ABCA transporters in lipid homeostasis ABC-family proteins mediated transport ABH2 mediated Reversal of Alkylation Damage ABH3 mediated Reversal of Alkylation Damage Abnormal metabolism in phenylketonuria Acetylation Acetylcholine Neurotransmitter Release Cycle Acetylcholine regulates insulin secretion Acrosome Reaction Activated NOTCH1 Transmits Signal to the Nucleus Activation and oligomerization of BAK protein Activation of ATR in response to replication stress Activation of BAD and translocation to mitochondria Activation of BIM and translocation to mitochondria Activation of Ca-permeable Kainate Receptor Activation of caspases through apoptosome-mediated cleavage Activation of DNA fragmentation factor Activation of G protein gated Potassium channels Activation of gene expression by SREBF (SREBP) Activation of Matrix Metalloproteinases Activation of NF-kappaB in B cells Activation of NIMA Kinases NEK9, NEK6, NEK7 Activation of NOXA and translocation to mitochondria Activation of PKB Activation of PUMA and translocation to mitochondria Activation of Rac Activation of RAS in B cells Activation of SMO Activation of the AP-1 family of transcription factors Activation of the phototransduction cascade Activation of the pre-replicative complex Activation, myristolyation of BID and translocation to mitochondria Activation, translocation and oligomerization of BAX Acyl chain remodeling of CL Acyl chain remodeling of DAG and TAG Acyl chain remodelling of PC Acyl chain remodelling of PE Acyl chain remodelling of PG Acyl chain remodelling of PI Adenosine P1 receptors Adenylate cyclase inhibitory pathway Adherens junctions interactions ADP signalling through P2Y purinoceptor 1 Adrenaline signalling through Alpha-2 adrenergic receptor Advanced glycosylation endproduct receptor signaling Aflatoxin activation and detoxification Agmatine biosynthesis AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Alpha-defensins alpha-linolenic acid (ALA) metabolism Alpha-oxidation of phytanate Alternative complement activation Amino acid synthesis and interconversion (transamination) Amino acid transport across the plasma membrane Amyloids Anchoring of the basal body to the plasma membrane Androgen biosynthesis Antagonism of Activin by Follistatin Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing: Ubiquitination & Proteasome degradation APC truncation mutants have impaired AXIN binding APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Apoptotic execution phase Arachidonate production from DAG ARL13B-mediated ciliary trafficking of INPP5E ARMS-mediated activation Asparagine N-linked glycosylation Assembly Of The HIV Virion Assembly of the primary cilium Assembly of the RAD51-ssDNA nucleoprotein complex Association of TriC/CCT with target proteins during biosynthesis Astrocytic Glutamate-Glutamine Uptake And Metabolism Asymmetric localization of PCP proteins ATF4 activates genes ATM mediated phosphorylation of repair proteins ATP sensitive Potassium channels Attachment of GPI anchor to uPAR Attenuation phase AUF1 (hnRNP D0) destabilizes mRNA Autodegradation of Cdh1 by Cdh1:APC/C Autodegradation of the E3 ubiquitin ligase COP1 Autointegration results in viral DNA circles Axonal growth inhibition (RHOA activation) Basigin interactions BBSome-mediated cargo-targeting to cilium Beta defensins Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta-oxidation of pristanoyl-CoA BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Bicarbonate transporters Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Biosynthesis of A2E, implicated in retinal degradation Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein BMAL1:CLOCK,NPAS2 activates circadian gene expression Branched-chain amino acid catabolism Budding and maturation of HIV virion Butyrate Response Factor 1 (BRF1) destabilizes mRNA Ca2+ activated K+ channels Ca2+ pathway CaM pathway CaMK IV-mediated phosphorylation of CREB Carnitine synthesis Caspase-mediated cleavage of cytoskeletal proteins Catecholamine biosynthesis Cation-coupled Chloride cotransporters CD28 dependent PI3K/Akt signaling CDK-mediated phosphorylation and removal of Cdc6 CDO in myogenesis Cell surface interactions at the vascular wall Cell-extracellular matrix interactions cGMP effects Chemokine receptors bind chemokines CHL1 interactions Cholesterol biosynthesis Chondroitin sulfate biosynthesis ChREBP activates metabolic gene expression Chylomicron-mediated lipid transport Circadian Clock Citric acid cycle (TCA cycle) Class A/1 (Rhodopsin-like receptors) Class B/2 (Secretin family receptors) Class C/3 (Metabotropic glutamate/pheromone receptors) Class II GLUTs Classical antibody-mediated complement activation Classical Kir channels Clearance of Nuclear Envelope Membranes from Chromatin Cleavage of the damaged pyrimidine Cobalamin (Cbl, vitamin B12) transport and metabolism Coenzyme A biosynthesis Cohesin Loading onto Chromatin Collagen biosynthesis and modifying enzymes Collagen degradation Common Pathway Condensation of Prometaphase Chromosomes Condensation of Prophase Chromosomes Conjugation of phenylacetate with glutamine Conjugation of salicylate with glycine Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase COPI Mediated Transport COPII (Coat Protein 2) Mediated Vesicle Transport Costimulation by the CD28 family COX reactions Creatine metabolism CREB phosphorylation CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of CaMKK CRMPs in Sema3A signaling Crosslinking of collagen fibrils Cross-presentation of soluble exogenous antigens (endosomes) CS/DS degradation c-src mediated regulation of Cx43 function and closure of gap junctions CTLA4 inhibitory signaling Cyclin A/B1 associated events during G2/M transition Cyclin D associated events in G1 Cyclin E associated events during G1/S transition Cysteine formation from homocysteine Cytosolic iron-sulfur cluster assembly Cytosolic sulfonation of small molecules Cytosolic tRNA aminoacylation DAP12 interactions DAP12 signaling DARPP-32 events DCC mediated attractive signaling deactivation of the beta-catenin transactivating complex Deadenylation of mRNA Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective B4GALT7 causes EDS, progeroid type Defective BTD causes biotidinase deficiency Defective CHST14 causes EDS, musculocontractural type Defective CHST3 causes SEDCJD Defective CHSY1 causes TPBS Defective CUBN causes hereditary megaloblastic anemia 1 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective EXT2 causes exostoses 2 Defective FMO3 causes Trimethylaminuria (TMAU) Defective HLCS causes multiple carboxylase deficiency Defective MAN1B1 causes MRT15 Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective UGT1A1 causes hyperbilirubinemia Degradation of cysteine and homocysteine degradation of DVL Degradation of GABA Degradation of the extracellular matrix Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Depolymerisation of the Nuclear Lamina Deposition of new CENPA-containing nucleosomes at the centromere Dermatan sulfate biosynthesis Detoxification of Reactive Oxygen Species DEx/H-box helicases activate type I IFN and inflammatory cytokines production Digestion of dietary carbohydrate Digestion of dietary lipid disassembly of the destruction complex and recruitment of AXIN to the membrane Displacement of DNA glycosylase by APE1 Dissolution of Fibrin Clot DNA Damage/Telomere Stress Induced Senescence DNA methylation DNA replication initiation Dopamine Neurotransmitter Release Cycle Downregulation of ERBB2:ERBB3 signaling Downregulation of ERBB4 signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of TGF-beta receptor signaling Downstream signal transduction Downstream TCR signaling DSCAM interactions E2F mediated regulation of DNA replication ECM proteoglycans Effects of PIP2 hydrolysis EGFR downregulation EGFR Transactivation by Gastrin Electric Transmission Across Gap Junctions Elevation of cytosolic Ca2+ levels Endogenous sterols Endosomal Sorting Complex Required For Transport (ESCRT) eNOS activation EPHA-mediated growth cone collapse EPHB-mediated forward signaling Ephrin signaling ER Quality Control Compartment (ERQC) ERK/MAPK targets ERK1 activation ERKs are inactivated Erythrocytes take up carbon dioxide and release oxygen Establishment of Sister Chromatid Cohesion Ethanol oxidation Eukaryotic Translation Elongation Extrinsic Pathway Facilitative Na+-independent glucose transporters Factors involved in megakaryocyte development and platelet production Fanconi Anemia pathway FasL/ CD95L signaling Fatty acid, triacylglycerol, and ketone body metabolism Fatty acids Fatty Acyl-CoA Biosynthesis FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation FGFR4 ligand binding and activation Fibronectin matrix formation Ficolins bind to repetitive carbohydrate structures on the target cell surface FMO oxidises nucleophiles Formation of annular gap junctions Formation of ATP by chemiosmotic coupling Formation of editosomes by ADAR proteins Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of incision complex in GG-NER Formation of Senescence-Associated Heterochromatin Foci (SAHF) Formation of the active cofactor, UDP-glucuronate formation of the beta-catenin:TCF transactivating complex Formation of transcription-coupled NER (TC-NER) repair complex Free fatty acid receptors FRS2-mediated cascade Fructose catabolism G alpha (12/13) signalling events G alpha (i) signalling events G alpha (q) signalling events G alpha (s) signalling events G alpha (z) signalling events G0 and Early G1 G2/M DNA damage checkpoint GAB1 signalosome GABA A (rho) receptor activation GABA A receptor activation GABA B receptor activation GABA synthesis Galactose catabolism Gamma-carboxylation of protein precursors Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Gap junction assembly Gap junction degradation Generation of second messenger molecules Generic Transcription Pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucocorticoid biosynthesis Gluconeogenesis Glucose transport Glucuronidation Glutathione conjugation Glutathione synthesis and recycling Glycogen breakdown (glycogenolysis) Glycogen synthesis Glycolysis Glycoprotein hormones Glycosphingolipid metabolism Glyoxylate metabolism Golgi Associated Vesicle Biogenesis Golgi Cisternae Pericentriolar Stack Reorganization GP1b-IX-V activation signalling Growth hormone receptor signaling GTP hydrolysis and joining of the 60S ribosomal subunit HATs acetylate histones HCN channels HDACs deacetylate histones HDL-mediated lipid transport HDMs demethylate histones Hedgehog ligand biogenesis Hedgehog 'off' state Hedgehog 'on' state Heme biosynthesis Heme degradation Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly sodium permeable acetylcholine nicotinic receptors Histidine catabolism HIV elongation arrest and recovery Homologous DNA pairing and strand exchange Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis HSF1 activation HSF1-dependent transactivation HS-GAG biosynthesis HS-GAG degradation HuR stabilizes mRNA Hyaluronan biosynthesis and export Hyaluronan uptake and degradation Hydrolysis of LPC Hydroxycarboxylic acid-binding receptors Hypusine synthesis from eIF5A-lysine IKK complex recruitment mediated by RIP1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Import of palmitoyl-CoA into the mitochondrial matrix Inactivation of Cdc42 and Rac Inactivation, recovery and regulation of the phototransduction cascade Inhibition of Host mRNA Processing and RNA Silencing Inhibition of TSC complex formation by PKB Initial triggering of complement Initiation of Nuclear Envelope Reformation Inositol transporters Insulin effects increased synthesis of Xylulose-5-Phosphate Insulin processing Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA Integrin alphaIIb beta3 signaling Integrin cell surface interactions Interaction between L1 and Ankyrins Interaction With Cumulus Cells Interaction With The Zona Pellucida Interconversion of 2-oxoglutarate and 2-hydroxyglutarate Interconversion of polyamines Interferon alpha/beta signaling Interferon gamma signaling Interleukin receptor SHC signaling Interleukin-1 processing Interleukin-1 signaling Interleukin-2 signaling Interleukin-6 signaling Interleukin-7 signaling Intraflagellar transport Intrinsic Pathway Ion transport by P-type ATPases IRE1alpha activates chaperones Iron uptake and transport IRS activation IRS-related events triggered by IGF1R ISG15 antiviral mechanism Keratan sulfate biosynthesis Keratan sulfate degradation Kinesins KSRP destabilizes mRNA L1CAM interactions Laminin interactions LDL-mediated lipid transport Ligand-gated ion channel transport Ligand-receptor interactions Localization of the PINCH-ILK-PARVIN complex to focal adhesions Loss of proteins required for interphase microtubule organization from the centrosome LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Lysine catabolism Lysosome Vesicle Biogenesis MASTL Facilitates Mitotic Progression Meiotic recombination Meiotic synapsis Metabolism of Angiotensinogen to Angiotensins Metabolism of folate and pterines Metabolism of nucleotides Metabolism of polyamines Metabolism of serotonin Metal ion SLC transporters Methionine salvage pathway Methylation MHC class II antigen presentation MicroRNA (miRNA) biogenesis Mineralocorticoid biosynthesis Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) misspliced GSK3beta mutants stabilize beta-catenin misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitochondrial ABC transporters mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Mitochondrial iron-sulfur cluster biogenesis Mitochondrial protein import Mitochondrial transcription initiation Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination Mitochondrial tRNA aminoacylation Mitotic Prometaphase Mitotic Telophase/Cytokinesis Molecules associated with elastic fibres Molybdenum cofactor biosynthesis MPS I - Hurler syndrome MPS II - Hunter syndrome MPS IIIA - Sanfilippo syndrome A MPS IIIB - Sanfilippo syndrome B MPS IIIC - Sanfilippo syndrome C MPS IV - Morquio syndrome A MPS IX - Natowicz syndrome MPS VII - Sly syndrome mRNA decay by 3' to 5' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Editing: C to U Conversion mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Multifunctional anion exchangers Muscarinic acetylcholine receptors MyD88 cascade initiated on plasma membrane MyD88:Mal cascade initiated on plasma membrane Na+/Cl- dependent neurotransmitter transporters Na+-dependent glucose transporters NADE modulates death signalling NADPH regeneration NCAM signaling for neurite out-growth NCAM1 interactions Nectin/Necl trans heterodimerization Nef Mediated CD8 Down-regulation Nef mediated downregulation of MHC class I complex cell surface expression negative regulation of TCF-dependent signaling by DVL-interacting proteins negative regulation of TCF-dependent signaling by WNT ligand antagonists Negative regulation of the PI3K/AKT network Negative regulators of RIG-I/MDA5 signaling Nephrin interactions Netrin mediated repulsion signals Netrin-1 signaling Neurofascin interactions Neurophilin interactions with VEGF and VEGFR NF-kB is activated and signals survival NGF processing NGF-independant TRKA activation N-Glycan antennae elongation N-glycan trimming and elongation in the cis-Golgi N-glycan trimming in the ER and Calnexin/Calreticulin cycle Nicotinamide salvaging Nicotinate metabolism Nitric oxide stimulates guanylate cyclase NOD1/2 Signaling Pathway Nonhomologous End-joining (NHEJ) Non-integrin membrane-ECM interactions Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) NoRC negatively regulates rRNA expression NOSIP mediated eNOS trafficking NOSTRIN mediated eNOS trafficking NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway NRAGE signals death through JNK NrCAM interactions Nuclear import of Rev protein Nuclear Receptor transcription pathway Nuclear signaling by ERBB4 O-glycosylation of TSR domain-containing proteins Olfactory Signaling Pathway O-linked glycosylation of mucins Oncogene Induced Senescence Opsins Orc1 removal from chromatin Organic anion transport Organic anion transporters Organic cation transport Orphan transporters Other semaphorin interactions Oxidative Stress Induced Senescence Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha p130Cas linkage to MAPK signaling for integrins p38MAPK events p53-Dependent G1 DNA Damage Response p75NTR negatively regulates cell cycle via SC1 p75NTR recruits signalling complexes Packaging Of Telomere Ends Passive transport by Aquaporins PCP/CE pathway PD-1 signaling Pentose phosphate pathway (hexose monophosphate shunt) Peptide ligand-binding receptors PERK regulates gene expression Peroxisomal lipid metabolism Phagosomal maturation (early endosomal stage) Phenylalanine and tyrosine catabolism Phosphate bond hydrolysis by NUDT proteins Phospholipase C-mediated cascade phospho-PLA2 pathway Phosphorylation of the APC/C PI and PC transport between ER and Golgi membranes PI-3K cascade PIP3 activates AKT signaling PIWI-interacting RNA (piRNA) biogenesis PKA activation in glucagon signalling PKMTs methylate histone lysines Plasmalogen biosynthesis Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Platelet degranulation Platelet homeostasis Platelet sensitization by LDL PLC beta mediated events Polymerase switching Polymerase switching on the C-strand of the telomere Post-chaperonin tubulin folding pathway Potassium transport channels POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation PP2A-mediated dephosphorylation of key metabolic factors PPARA activates gene expression PRC2 methylates histones and DNA Prefoldin mediated transfer of substrate to CCT/TriC Pregnenolone biosynthesis Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in the Endoplasmic Reticulum Presynaptic function of Kainate receptors Processing of Capped Intron-Containing Pre-mRNA Processing of DNA ends prior to end rejoining Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 Prolactin receptor signaling Proline catabolism Propionyl-CoA catabolism Prostacyclin signalling through prostacyclin receptor Prostanoid ligand receptors Proton/oligonucleotide cotransporters Proton-coupled monocarboxylate transport Proton-coupled neutral amino acid transporters Purine catabolism Purine ribonucleoside monophosphate biosynthesis Purine salvage Pyrimidine biosynthesis Pyrimidine catabolism Pyrimidine salvage reactions Pyruvate metabolism RA biosynthesis pathway RAF activation Rap1 signalling Ras activation uopn Ca2+ infux through NMDA receptor Reactions specific to the complex N-glycan synthesis pathway Reactions specific to the hybrid N-glycan synthesis pathway Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes Recruitment of repair and signaling proteins to double-strand breaks Recycling of bile acids and salts Recycling of eIF2:GDP Recycling pathway of L1 Regulated proteolysis of p75NTR Regulation by c-FLIP Regulation by TREX1 Regulation of actin dynamics for phagocytic cup formation Regulation of AMPK activity via LKB1 Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of Commissural axon pathfinding by Slit and Robo Regulation of Complement cascade Regulation of cytoskeletal remodeling and cell spreading by IPP complex components regulation of FZD by ubiquitination Regulation of gene expression by Hypoxia-inducible Factor Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of HSF1-mediated heat shock response Regulation of IFNA signaling Regulation of IFNG signaling Regulation of innate immune responses to cytosolic DNA Regulation of insulin secretion Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Regulation of KIT signaling Regulation of ornithine decarboxylase (ODC) Regulation of PLK1 Activity at G2/M Transition Regulation of pyruvate dehydrogenase (PDH) complex Regulation of signaling by CBL Regulation of signaling by NODAL Regulation of the Fanconi anemia pathway Regulation of thyroid hormone activity Release of apoptotic factors from the mitochondria Release of eIF4E Release of Hh-Np from the secreting cell Removal of DNA patch containing abasic residue Removal of licensing factors from origins Removal of the Flap Intermediate from the C-strand repression of WNT target genes Resolution of AP sites via the single-nucleotide replacement pathway Respiratory electron transport Retinoid metabolism and transport Retrograde neurotrophin signalling REV-ERBA represses gene expression Reversible hydration of carbon dioxide Rev-mediated nuclear export of HIV RNA Rhesus glycoproteins mediate ammonium transport. Rho GTPase cycle Ribosomal scanning and start codon recognition RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways RMTs methylate histone arginines RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase I Chain Elongation RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase II Promoter Escape RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Termination Role of Abl in Robo-Slit signaling Role of DCC in regulating apoptosis Role of LAT2/NTAL/LAB on calcium mobilization Role of phospholipids in phagocytosis Role of second messengers in netrin-1 signaling RORA activates circadian gene expression RSK activation S6K1 signalling Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Scavenging of heme from plasma Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Senescence-Associated Secretory Phenotype (SASP) Separation of Sister Chromatids Serine biosynthesis Serotonin and melatonin biosynthesis SHC-mediated cascade SHC-mediated signalling Sialic acid metabolism Signal attenuation Signal regulatory protein (SIRP) family interactions Signal transduction by L1 Signaling by activated point mutants of FGFR1 Signaling by Activin Signaling by BMP Signaling by EGFR Signaling by ERBB2 Signaling by FGFR1 fusion mutants Signaling by FGFR2 amplification mutants Signaling by FGFR3 mutants Signaling by Hippo Signaling by NODAL Signaling by NOTCH4 Signaling by PDGF Signaling by Retinoic Acid Signaling by Robo receptor Signaling by SCF-KIT Signalling to ERK5 Signalling to p38 via RIT and RIN SIRT1 negatively regulates rRNA Expression SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SMAC binds to IAPs SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Small interfering RNA (siRNA) biogenesis Smooth Muscle Contraction snRNP Assembly Sodium/Calcium exchangers Sodium/Proton exchangers Sodium-coupled phosphate cotransporters Sodium-coupled sulphate, di- and tri-carboxylate transporters Sperm Motility And Taxes Sperm:Oocyte Membrane Binding Sphingolipid de novo biosynthesis Spry regulation of FGF signaling SRP-dependent cotranslational protein targeting to membrane Stimulation of the cell death response by PAK-2p34 Stimuli-sensing channels STING mediated induction of host immune responses Striated Muscle Contraction Sulfide oxidation to sulfate Sulfur amino acid metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is proteolytically processed Syndecan interactions Synthesis and interconversion of nucleotide di- and triphosphates Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of 5-eicosatetraenoic acids Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of diphthamide-EEF2 Synthesis of Dolichyl-phosphate Synthesis of dolichyl-phosphate mannose Synthesis of dolichyl-phosphate-glucose Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of GDP-mannose Synthesis of glycosylphosphatidylinositol (GPI) Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Synthesis of IPs in the ER lumen Synthesis of IPs in the nucleus Synthesis of Ketone Bodies Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Synthesis of PA Synthesis of PC Synthesis of PE Synthesis of PG Synthesis of PI Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the plasma membrane Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Synthesis of PS Synthesis of pyrophosphates in the cytosol Synthesis of UDP-N-acetyl-glucosamine Synthesis of very long-chain fatty acyl-CoAs Synthesis, secretion, and deacylation of Ghrelin Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Tandem pore domain halothane-inhibited K+ channel (THIK) TCF dependent signaling in response to WNT TCF7L2 mutants don't bind CTBP Telomere Extension By Telomerase Termination of O-glycan biosynthesis TET1,2,3 and TDG demethylate DNA Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) The AIM2 inflammasome The canonical retinoid cycle in rods (twilight vision) The IPAF inflammasome The NLRP1 inflammasome The NLRP3 inflammasome The proton buffering model Thrombin signalling through proteinase activated receptors (PARs) Thyroxine biosynthesis Tie2 Signaling Tight junction interactions TNF signaling Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 9 (TLR9) Cascade Toll Like Receptor TLR1:TLR2 Cascade Toxicity of botulinum toxin type B (BoNT/B) Toxicity of botulinum toxin type C (BoNT/C) Toxicity of botulinum toxin type D (BoNT/D) Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type G (BoNT/G) TRAF3-dependent IRF activation pathway TRAF6 mediated induction of TAK1 complex TRAF6 mediated IRF7 activation Trafficking and processing of endosomal TLR Trafficking of AMPA receptors Trafficking of dietary sterols Trafficking of GluR2-containing AMPA receptors Trafficking of myristoylated proteins to the cilium TRAIL signaling Transcriptional activation of cell cycle inhibitor p21 Transcriptional activation of mitochondrial biogenesis Transcriptional regulation by small RNAs Transcriptional regulation of pluripotent stem cells Transcriptional regulation of white adipocyte differentiation Transferrin endocytosis and recycling Translation initiation complex formation Translesion synthesis by HREV1 Translesion synthesis by Pol eta Translesion synthesis by Pol zeta Translocation of GLUT4 to the plasma membrane Transport and synthesis of PAPS Transport of connexons to the plasma membrane Transport of fatty acids Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Transport of glycerol from adipocytes to the liver by Aquaporins Transport of inorganic cations/anions and amino acids/oligopeptides Transport of Mature mRNA derived from an Intron-Containing Transcript Transport of Mature mRNA Derived from an Intronless Transcript Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Transport of nucleotide sugars Transport of organic anions Transport of vitamins, nucleosides, and related molecules Transport to the Golgi and subsequent modification Triglyceride Biosynthesis Tristetraprolin (TTP) destabilizes mRNA TRP channels Tryptophan catabolism TWIK related potassium channel (TREK) TWIK-related alkaline pH activated K+ channel (TALK) TWIK-related spinal cord K+ channel (TRESK) TWIK-releated acid-sensitive K+ channel (TASK) Type I hemidesmosome assembly Type II Na+/Pi cotransporters Ubiquinol biosynthesis Unwinding of DNA Urea cycle Utilization of Ketone Bodies Vasopressin regulates renal water homeostasis via Aquaporins Vasopressin-like receptors VEGF binds to VEGFR leading to receptor dimerization VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Vif-mediated degradation of APOBEC3G Viral mRNA Translation Vitamin B1 (thiamin) metabolism Vitamin B2 (riboflavin) metabolism Vitamin B5 (pantothenate) metabolism Vitamin C (ascorbate) metabolism Vitamin D (calciferol) metabolism Vitamins Vitamins B6 activation to pyridoxal phosphate Voltage gated Potassium channels Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Vpu mediated degradation of CD4 vRNP Assembly VxPx cargo-targeting to cilium WNT ligand biogenesis and trafficking WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 WNT mediated activation of DVL WNT5A-dependent internalization of FZD2, FZD5 and ROR2 XBP1(S) activates chaperone genes Xenobiotics YAP1- and WWTR1 (TAZ)-stimulated gene expression ZBP1(DAI) mediated induction of type I IFNs Zinc efflux and compartmentalization by the SLC30 family Zinc influx into cells by the SLC39 gene family Records per page 10 20 50 100 200 500 1000 All Sort by: Gene Symbol Species Entrez Gene ID Gene Name MGP_ID