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MB Sample ID: SA226590
| Local Sample ID: | B14 |
| Subject ID: | SU002388 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Age Or Age Range: | >=18 |
| Gender: | Male and female |
| Human Race: | Chinese |
| Human Ethnicity: | Han |
| Human Trial Type: | observational study |
| Human Medications: | Dupilumab |
| Human Inclusion Criteria: | 1.Age ≥ 18 years of age 2.Dermatologist diagnosis of moderate to severe AD, EASI≥16 at baseline 3.Eligible to receive dupilumab therapy for AD in accordance with the guidelines. Patients who are eligible were treated with a fixed schedule of 300mg dupilumab in 2-week intervals. Patients who did not achieve 16-week therapy were excluded. 4.During the whole treatment process, the requirements for diet and exercise are roughly the same as before treatment, so as to keep the body healthy and balanced 5.A 30-day washout period of systemic medications preceded treatment |
| Human Exclusion Criteria: | 1Evidence of other skin diseases except for AD at baseline 2.Pregnancy or breast feeding, 3.Patients with permanent severe diseases, especially those affecting the immune system, except asthma 4.Patients with severe mental illness 5.Evidence of chronic metabolic disease, including Obesity, diabetes, fatty liver, osteoporosis, atherosclerotic cardiovascular and cerebrovascular diseases, and metabolic-related cancers (breast, colorectal, pancreatic, colon, and prostate cancer). 6.Application of other systemic medications during treatment |
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Combined analysis:
| Analysis ID | AN003758 | AN003759 | AN003760 | AN003761 | AN003762 |
|---|---|---|---|---|---|
| Analysis type | MS | MS | MS | MS | MS |
| Chromatography type | GC | HILIC | HILIC | HILIC | HILIC |
| Chromatography system | Agilent 7890N | Thermo Vanquish | Thermo Vanquish | Thermo Vanquish | Thermo Vanquish |
| Column | Agilent DB5-MS (30m x 0.25mm, 0.25um) | Waters Acquity BEH C8 (100 x 2.1mm,1.7um) | Waters Acquity BEH C8 (100 x 2.1mm,1.7um) | Waters Acquity BEH C8 (100 x 2.1mm,1.7um) | Waters Acquity BEH C8 (100 x 2.1mm,1.7um) |
| MS Type | EI | ESI | ESI | ESI | ESI |
| MS instrument type | GC-TOF | Orbitrap | Orbitrap | Orbitrap | Orbitrap |
| MS instrument name | Agilent 7890A | Thermo Q Exactive HF-X Orbitrap | Thermo Q Exactive HF-X Orbitrap | Thermo Q Exactive HF-X Orbitrap | Thermo Q Exactive HF-X Orbitrap |
| Ion Mode | UNSPECIFIED | POSITIVE | NEGATIVE | POSITIVE | NEGATIVE |
| Units | Peak area | Peak area | Peak area | Peak area | Peak area |
