Summary of Study ST001929
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001218. The data can be accessed directly via it's Project DOI: 10.21228/M88H76 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001929 |
Study Title | Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype (Part 2) |
Study Summary | Urinary O-desmethylangolensin (ODMA) concentrations provide a functional gut microbiome marker of dietary isoflavone daidzein metabolism to ODMA. Individuals who do not have gut microbial environments that produce ODMA have less favorable cardiometabolic and cancer risk profiles. Urinary metabolomics profiles were evaluated in relation to ODMA metabotypes within and between individuals over time. Secondary analysis was conducted of data from the BEAN2 trial, which was a cross-over study of premenopausal women consuming six months on a high- and a low-soy diet, each separated by a 1-month washout period. In all of the 672 samples in the study, 66 of the 84 women had the same ODMA metabotype at seven or all eight time points. Two or four urine samples per woman were selected based on temporal metabotypes in order to compare within and across individuals. Metabolomics assays for primary metabolism and biogenic amines were conducted in 60 urine samples from 20 women. |
Institute | George Mason University |
Last Name | Frankenfeld |
First Name | Cara |
Address | 4400 University Drive, Fairfax, VA 22030 |
prof.frankenfeld@gmail.com | |
Phone | 2062652563 |
Submit Date | 2021-08-23 |
Raw Data Available | Yes |
Analysis Type Detail | GC-MS |
Release Date | 2021-11-02 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN003137 |
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Analysis type | MS |
Chromatography type | GC |
Chromatography system | Leco Pegasus IV GC |
Column | Restek Rtx-5Sil (30m x 0.25mm,0.25um) |
MS Type | EI |
MS instrument type | GC-TOF |
MS instrument name | Leco Pegasus IV TOF |
Ion Mode | POSITIVE |
Units | Peak height |
Chromatography:
Chromatography ID: | CH002319 |
Chromatography Summary: | Urine samples were analyzed by the National Institutes of Health (NIH) West Coast Metabolomics Center in the Fiehn laboratory, using established protocols and more detail on these protocols are available elsewhere (Fiehn et al 2008). To consider broad aspects of metabolism relevant to diet, primary metabolism and biogenic amines platforms were evaluated. In brief, primary metabolism metabolites were assayed using automated liner exchange-cold injection system, gas chromatography-time of flight mass spectrometry (ALEX-CIS GCTOF). |
Instrument Name: | Leco Pegasus IV GC |
Column Name: | Restek Rtx-5Sil (30m x 0.25mm,0.25um) |
Chromatography Type: | GC |