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MB Sample ID: SA323814
| Local Sample ID: | 22 |
| Subject ID: | SU003097 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Gender: | Male and female |
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Collection:
| Collection ID: | CO003090 |
| Collection Summary: | Residual serum samples for biochemical and immunological tests were collected from patients with suspected SARS-CoV-2 infection who underwent RT-PCR testing of nasopharyngeal swab or saliva samples at Keio University Hospital or Osaka Metropolitan University Hospital from March 2020 to January 2021. The diagnosis of COVID-19 was based on a positive RT-PCR test from a nasopharyngeal swab or saliva sample. The classification of severity was based on the Japanese Ministry of Health, Labour and Welfare’s classification of severity (criteria for evaluation by healthcare professionals) and was defined as follows: asymptomatic, no symptoms associated with COVID-19; mild disease, SARS-CoV-2-positive with no findings of pneumonia; moderate disease, SARS-CoV-2-positive with findings of pneumonia but not requiring a ventilator or intensive care unit (ICU) management; and severe disease, SARS-CoV-2-positive requiring ventilator or ICU management, including death attributed to COVID-19 during the treatment period. For a negative control, residual serum samples were collected from patients who underwent RT-PCR testing using nasopharyngeal swab fluid between April and May 2020 at Keio University Hospital and received negative RT-PCR test results, making them clinically unlikely to have COVID-19. The study included the early patient cohorts of waves 1, 2, and 3 of COVID-19 conducted in Japan from March to December 2020. For cohorts 1 and 2, patients were not excluded because of comorbidities, as the main objective was to include the greatest possible number of severe cases for which specimens were available early after disease onset. Cases in the mild and moderate groups were selected based on matching age and sex distribution with the severe group. No specific exclusions were made in any group during the study period, mainly because the number of samples was limited. Asymptomatic and mildly symptomatic patients were selected for inclusion by balancing the sex ratio. The higher proportion of males in the moderate and severe categories is due to the observed tendency for males to be more severely affected. This was particularly true for patients hospitalized during the study period. Sample collection and utilization were conducted under the approval of the Ethics Committee of the Keio University School of Medicine (approval numbers 20200059 and 20200063) and the Ethics Committee of Osaka Metropolitan University Graduate School of Medicine (approval number 2020-003). The use of residual samples was conducted on an opt-out basis based on the approval of the relevant ethics committees. All samples were stored at -80 °C. |
| Sample Type: | Blood (serum) |
| Storage Conditions: | -80℃ |
