Summary of Study ST001411
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000967. The data can be accessed directly via it's Project DOI: 10.21228/M8PX1S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001411 |
Study Title | Plasma metabolites of lipid metabolism associate with diabetic polyneuropathy in a cohort with screen-tested type 2 diabetes: ADDITION-Denmark |
Study Summary | The global rise in type 2 diabetes (T2D) is associated with a concomitant increase in diabetic complications. Diabetic polyneuropathy (DPN), the most frequent T2D complication, is characterized by sensory peripheral nerve damage. Although managing glucose effectively slows DPN progression in type 1 diabetes patients, it has limited efficacy in neuropathic T2D patients. The metabolic syndrome (MetS) recently emerged as a major risk factor for DPN; however, the metabolites associated with MetS that correlate with DPN are unknown. We conducted a global plasma metabolomics analysis from a cohort of patients enrolled in the Anglo-Danish-Dutch study of Intensive Treatment of Diabetes in Primary Care (ADDITION), including healthy control subjects, T2D patients, and T2D DPN patients. We identified 15 total plasma metabolites that were altered in T2D DPN patients, including lipids, amino acids, and energy-related metabolites. We evaluated the correlation between these metabolites and all lipid species to identify major changes in both plasma free fatty acids and complex lipids in T2D DPN patients, and found significant alterations in the abundance of long-chain saturated fatty acids, acylcarnitines, and sphingolipids. Our study suggests that DPN in T2D is associated with novel alterations in plasma metabolites related to lipid metabolism. |
Institute | University of Michigan |
Last Name | Feldman |
First Name | Eva |
Address | 5017 AATBSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 |
efeldman@med.umich.edu | |
Phone | 7347637274 |
Submit Date | 2020-06-22 |
Num Groups | 3 |
Total Subjects | 106 |
Num Males | 83 |
Num Females | 23 |
Raw Data File Type(s) | wiff |
Analysis Type Detail | LC-MS |
Release Date | 2021-06-15 |
Release Version | 1 |
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Collection:
Collection ID: | CO001480 |
Collection Summary: | At the mean 13 year follow up after T2D diagnosis, blood samples were collected from patients the same day as anthropometrics and DPN assessment. Plasma was collected in purple EDTA tubes with 10 mL of buffy coat, inverted 10 times, incubated for 30-90 minutes at room temperature, and centrifuged at 3000 rpm for 10 minutes. The plasma supernatant was collected by aspirating plasma to approximately 5 mm above the buffy coat and plasma samples were stored in 0.5 mL aliquots at -80C prior to metabolomics analysis. |
Sample Type: | Blood (plasma) |