Summary of Study ST003177

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001976. The data can be accessed directly via it's Project DOI: 10.21228/M89J06 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003177
Study TitleA Longitudinal Study in Rheumatoid Arthritis Unveils Metabolomic Biomarkers Preceding Clinical Onset, Assessing Disease Severity, and Anticipating Treatment Response to csDMARDs
Study SummaryRheumatoid arthritis (RA) is a bundle of systemic inflammatory diseases mainly affecting the joints, complicating the identification of biomarkers for early diagnosis, predicting disease progress and therapeutic outcomes. This study scrutinizes a longitudinal cohort of RA, inclusive of follow-ups, alongside OA, UA and ACPA/RF-RA and healthy controls, aiming to discover plasma metabolic markers that can precede RA onset, assess disease activity, and forecast treatment efficacy. Our investigation revealed substantial metabolic alterations at both the pathway and individual metabolite levels across RA, at-risk or RA and healthy control. The drug response predictive models constructed on critical differential metaboites showed optimal performance. Additionally, our longitudinal data sheds light on the molecular impacts on metabolism of csDMARDs in RA.
Institute
West China Hospital of Sichuan University
Last NameZhu
First NameChenxi
AddressWest China Hospital, Sichuan University, 37# Guoxue Xiang, Chengdu, Sichuan, 610041, China.
Emailchenxizhu1995@gmail.com
Phone+8615026603760
Submit Date2024-04-12
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-05-11
Release Version1
Chenxi Zhu Chenxi Zhu
https://dx.doi.org/10.21228/M89J06
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO003289
Collection Summary:The study collected plasma samples from all participants at West China Hospital, Sichuan University. These were approved by the Research Ethics Committee of West China Hospital, Sichuan University (Permission number: 2021(790)), and informed consent was obtained from all participants. Patients were diagnosed with RA according to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria. The healthy control group consisted of individuals matched in age and gender, with no history or clinical evidence of autoimmune or rheumatic diseases. Blood collection followed standard venipuncture procedures using anticoagulant tubes. Plasma samples were obtained after centrifugation and stored at -80°C. ACPA levels were measured using Elecsys anti-CCP detection on the Cobas® e 801 module (Roche Diagnostics, Mannheim, Germany), with results categorized as positive (≥17.0 U/ml) or negative (<17.0 U/ml).
Sample Type:Blood (plasma)
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