Summary of Study ST002706
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001677. The data can be accessed directly via it's Project DOI: 10.21228/M8XQ5D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002706 |
Study Title | Plasma metabolomics of Bmal1-KO and Bmal1-KO+AAV |
Study Summary | Disruption of the circadian clock in skeletal muscle worsens local and systemic health, leading to decreased muscle strength, metabolic dysfunction, and aging-like phenotypes. Whole-body knockout mice that lack Bmal1, a key component of the molecular clock, display premature aging. Here, by using adeno-associated viruses, we rescued Bmal1 expression specifically in the skeletal muscle of Bmal1-KO mice and found that this improves their healthspan and lifespan. Plasma samples from 40-week-old KO and KO+AAV male mice were collected at ZT1 to characterize the systemic effects of muscle-specific expression of Bmal1. Overall, our findings highlight the critical role of skeletal muscle in systemic health. |
Institute | University of Florida |
Last Name | Esser |
First Name | Karyn |
Address | 1345 Center Drive, M552, Gainesville, Florida, 32610, USA |
kaesser@ufl.edu | |
Phone | 352-273-5728 |
Submit Date | 2023-05-16 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzXML |
Analysis Type Detail | LC-MS |
Release Date | 2024-05-31 |
Release Version | 1 |
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Collection:
Collection ID: | CO002804 |
Collection Summary: | Mice were anesthetized using isofluorane. Blood was collected by intracardiac puncture. EDTA was used as anticoagulant. Blood was centrifuged at 2,000xg for 15 mins and plasma was collected and subsequently frozen in liquid nitrogen. Samples are stored at -80°C. |
Sample Type: | Blood (plasma) |
Storage Conditions: | -80℃ |