Summary of Study ST003189
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001985. The data can be accessed directly via it's Project DOI: 10.21228/M84Q71 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003189 |
| Study Title | Untargeted Metabolomic Profile of Septic Shock in the Emergency Department |
| Study Summary | Septic shock is a life-threatening condition that arises from a dysregulated host response to infection, resulting in the failure of multiple organ systems and the rapid decline of the patient’s health status. As a medical emergency, early recognition and timely interventions are crucial for improving patient outcomes, particularly in the emergency department setting where septic patients are initially treated. Despite the importance of early identification, current diagnostic tools remain challenges in predicting septic shock at the time of admission. To address these limitations, this study aimed to develop a highly sensitive and specific platform for predicting septic shock in the emergency department. By implementing a supervised algorithm to the metabolic profile, a model based on a 22-metabolite panel was developed to accurately predict septic shock. This approach has the potential to optimize the clinical management of septic shock in the emergency department. |
| Institute | National Taiwan University |
| Department | Department of Chemistry |
| Laboratory | Cheng-Chih Hsu's lab |
| Last Name | Hong |
| First Name | Yu |
| Address | No. 1, Sec. 4, Roosevelt Rd., Taipei, Taipei, 106, Taiwan |
| f07223179@ntu.edu.tw | |
| Phone | +886-2-3366-1681 |
| Submit Date | 2024-05-02 |
| Num Groups | 2 |
| Total Subjects | 124 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-05-28 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO003301 |
| Collection Summary: | Adult patients who visited the emergency department of Taipei Veterans General Hospital between Nov. 2018 and Feb. 2019 were prospectively enrolled with approval from the Institutional Review Board. Blood samples were obtained during routine clinical testing upon admission before initial treatment. These samples were collected in serum separator tubes, left to clot at room temperature for 1 h, and then centrifuged at 3000 rpm at 4 °C for 20 min. The resulting supernatant sera were promptly stored at -80°C before subsequent analysis. |
| Sample Type: | Blood (serum) |
