Summary of Study ST000513
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000383. The data can be accessed directly via it's Project DOI: 10.21228/M8JG7B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000513 |
Study Title | Inhibition of autophagy/proteasome degradation or inhibition of protein synthesis in models of muscle insulin resistance affect TCA cycle |
Study Summary | To determine which protein degradation pathways downstream of IR and IGF1R contribute to changes in amino acid and mitochondrial metabolite pools, we will treat control, M-IR-/-, MIGIRKO, and HFD obese mice with inhibitors of autophagy or proteasome. We will treat 5 animals each of control, M-IR-/-, MIGIRKO, and HFD mice with vehicle, colchicine to inhibit autophagy, or MG132 to inhibit proteasome activity, then measure TCA cycle in muscle tissue. |
Institute | Mayo Clinic |
Last Name | O'Neill |
First Name | Brian |
Address | One Joslin Place, Boston, MA 02215 |
brian.o'neill@joslin.harvard.edu | |
Phone | 617-309-2400 |
Submit Date | 2016-12-02 |
Analysis Type Detail | GC-MS |
Release Date | 2018-12-11 |
Release Version | 1 |
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Factors:
Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)
mb_sample_id | local_sample_id | group | genotype |
---|---|---|---|
SA026678 | Sample # 30 | Control/Colch | Irlox |
SA026679 | Sample # 29 | Control/Colch | Irlox |
SA026680 | Sample # 26 | Control/Colch | Irlox IGFRlox |
SA026681 | Sample # 27 | Control/Colch | Irlox IGFRlox |
SA026682 | Sample # 28 | Control/Colch | Irlox IGFRlox |
SA026683 | Sample # 25 | Control/Colch | Irlox IGFRlox |
SA026684 | Sample # 24 | Control/Colch | Irlox IGFRlox |
SA026685 | Sample # 6 | Control/Saline | Irlox |
SA026686 | Sample # 7 | Control/Saline | Irlox |
SA026687 | Sample # 5 | Control/Saline | Irlox |
SA026688 | Sample # 3 | Control/Saline | Irlox IGFRlox |
SA026689 | Sample # 2 | Control/Saline | Irlox IGFRlox |
SA026690 | Sample # 1 | Control/Saline | Irlox IGFRlox |
SA026691 | Sample # 4 | Control/Saline | Irlox IGFRlox |
SA026692 | Sample # 43 | HFD+Colch | Irlox |
SA026693 | Sample # 42 | HFD+Colch | Irlox |
SA026694 | Sample # 45 | HFD+Colch | Irlox |
SA026695 | Sample # 46 | HFD+Colch | Irlox |
SA026696 | Sample # 44 | HFD+Colch | Irlox IGFRlox |
SA026697 | Sample # 20 | HFD/Saline | Irlox |
SA026698 | Sample # 21 | HFD/Saline | Irlox |
SA026699 | Sample # 23 | HFD/Saline | Irlox |
SA026700 | Sample # 19 | HFD/Saline | Irlox |
SA026701 | Sample # 22 | HFD/Saline | Irlox IGFRlox |
SA026702 | Sample # 40 | IRKO/Colch | IR -/- |
SA026703 | Sample # 39 | IRKO/Colch | IR -/- |
SA026704 | Sample # 37 | IRKO/Colch | IR -/- |
SA026705 | Sample # 38 | IRKO/Colch | IR -/- |
SA026706 | Sample # 41 | IRKO/Colch | IR -/- |
SA026707 | Sample # 18 | IRKO/Saline | IR -/- |
SA026708 | Sample # 15 | IRKO/Saline | IR -/- |
SA026709 | Sample # 17 | IRKO/Saline | IR -/- |
SA026710 | Sample # 14 | IRKO/Saline | IR -/- |
SA026711 | Sample # 16 | IRKO/Saline | IR -/- |
SA026712 | Sample # 31 | MIGIRKO/Colch | IR -/- IGFR -/- |
SA026713 | Sample # 36 | MIGIRKO/Colch | IR -/- IGFR -/- |
SA026714 | Sample # 32 | MIGIRKO/Colch | IR -/- IGFR -/- |
SA026715 | Sample # 33 | MIGIRKO/Colch | IR -/- IGFR -/- |
SA026716 | Sample # 34 | MIGIRKO/Colch | IR -/- IGFR -/- |
SA026717 | Sample # 35 | MIGIRKO/Colch | IR -/- IGFR -/- |
SA026718 | Sample # 8 | MIGIRKO/Saline | IR -/- IGFR -/- |
SA026719 | Sample # 13 | MIGIRKO/Saline | IR -/- IGFR -/- |
SA026720 | Sample # 11 | MIGIRKO/Saline | IR -/- IGFR -/- |
SA026721 | Sample # 12 | MIGIRKO/Saline | IR -/- IGFR -/- |
SA026722 | Sample # 9 | MIGIRKO/Saline | IR -/- IGFR -/- |
SA026723 | Sample # 10 | MIGIRKO/Saline | IR -/- IGFR -/- |
Showing results 1 to 46 of 46 |