Summary of Study ST000885
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000614. The data can be accessed directly via it's Project DOI: 10.21228/M8KD9Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000885 |
Study Title | Gut Microbiota Modulate Brain Insulin Sensitivity and Neurobehavior |
Study Type | Metabolite profiling of cecal contents and brains of mice under diet-induced obesity (DIO) with and without antibiotic treatments. |
Study Summary | C57BL/6J mice were purchased from Jackson Laboratory and maintained on either a normal chow containing 22% of calories from fat, 23% from protein, and 55% from carbohydrates (Mouse diet 9F 5020; PharmaServ) or a high-fat diet (Open Source Diet, D12492; Research Diets) containing 60% of calories from fat, 20% from protein, and 20% from carbohydrates for 6 weeks. During the last 2 weeks, some of the HFD mice were treated with vancomycin or metronidazole (1 g/L in the drinking water). All mice were housed at 22°C on a 12 h light/dark cycle. All animal studies were approved by the IACUC of Joslin Diabetes Center (# 97-05) and Harvard Medical School (# 05131) and were in accordance with NIH guidelines. The metabolite profiling was conducted on plasma, hypothalamus and nucleus accumbens. |
Institute | Broad Institute of MIT and Harvard |
Last Name | Avila-Pacheco |
First Name | Julian |
Address | 415 Main Street |
jravilap@broadinstitute.org | |
Phone | 617-714-8264 |
Submit Date | 2017-10-30 |
Num Groups | 12 |
Total Subjects | 24 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2017-10-30 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Animal; Subject species: Mus musculus (Factor headings shown in green)
mb_sample_id | local_sample_id | Diet | Treatment | Tissue |
---|---|---|---|---|
SA051386 | 0002.d | Chow | none | hypothalamus |
SA051387 | 0004.d | Chow | none | hypothalamus |
SA051388 | 0014.d | Chow | none | hypothalamus |
SA051389 | 0022.d | Chow | none | hypothalamus |
SA051390 | 0015.d | Chow | none | hypothalamus |
SA051391 | 0010.d | Chow | none | hypothalamus |
SA051392 | 0039.d | Chow | none | nucleus accumbens |
SA051393 | 0034.d | Chow | none | nucleus accumbens |
SA051394 | 0026.d | Chow | none | nucleus accumbens |
SA051395 | 0046.d | Chow | none | nucleus accumbens |
SA051396 | 0028.d | Chow | none | nucleus accumbens |
SA051397 | 0038.d | Chow | none | nucleus accumbens |
SA051398 | 0050.d | Chow | none | plasma |
SA051399 | 0058.d | Chow | none | plasma |
SA051400 | 0063.d | Chow | none | plasma |
SA051401 | 0062.d | Chow | none | plasma |
SA051402 | 0052.d | Chow | none | plasma |
SA051403 | 0070.d | Chow | none | plasma |
SA051404 | 0008.d | HFD | metronidazole | hypothalamus |
SA051405 | 0012.d | HFD | metronidazole | hypothalamus |
SA051406 | 0006.d | HFD | metronidazole | hypothalamus |
SA051407 | 0001.d | HFD | metronidazole | hypothalamus |
SA051408 | 0018.d | HFD | metronidazole | hypothalamus |
SA051409 | 0047.d | HFD | metronidazole | nucleus accumbens |
SA051410 | 0036.d | HFD | metronidazole | nucleus accumbens |
SA051411 | 0025.d | HFD | metronidazole | nucleus accumbens |
SA051412 | 0042.d | HFD | metronidazole | nucleus accumbens |
SA051413 | 0030.d | HFD | metronidazole | nucleus accumbens |
SA051414 | 0032.d | HFD | metronidazole | nucleus accumbens |
SA051415 | 0060.d | HFD | metronidazole | plasma |
SA051416 | 0071.d | HFD | metronidazole | plasma |
SA051417 | 0054.d | HFD | metronidazole | plasma |
SA051418 | 0066.d | HFD | metronidazole | plasma |
SA051419 | 0049.d | HFD | metronidazole | plasma |
SA051420 | 0056.d | HFD | metronidazole | plasma |
SA051421 | 0013.d | HFD | none | hypothalamus |
SA051422 | 0021.d | HFD | none | hypothalamus |
SA051423 | 0024.d | HFD | none | hypothalamus |
SA051424 | 0020.d | HFD | none | hypothalamus |
SA051425 | 0007.d | HFD | none | hypothalamus |
SA051426 | 0011.d | HFD | none | hypothalamus |
SA051427 | 0035.d | HFD | none | nucleus accumbens |
SA051428 | 0037.d | HFD | none | nucleus accumbens |
SA051429 | 0044.d | HFD | none | nucleus accumbens |
SA051430 | 0031.d | HFD | none | nucleus accumbens |
SA051431 | 0045.d | HFD | none | nucleus accumbens |
SA051432 | 0048.d | HFD | none | nucleus accumbens |
SA051433 | 0069.d | HFD | none | plasma |
SA051434 | 0059.d | HFD | none | plasma |
SA051435 | 0055.d | HFD | none | plasma |
SA051436 | 0061.d | HFD | none | plasma |
SA051437 | 0068.d | HFD | none | plasma |
SA051438 | 0072.d | HFD | none | plasma |
SA051439 | 0019.d | HFD | vancomycin | hypothalamus |
SA051440 | 0005.d | HFD | vancomycin | hypothalamus |
SA051441 | 0009.d | HFD | vancomycin | hypothalamus |
SA051442 | 0016.d | HFD | vancomycin | hypothalamus |
SA051443 | 0017.d | HFD | vancomycin | hypothalamus |
SA051444 | 0003.d | HFD | vancomycin | hypothalamus |
SA051445 | 0043.d | HFD | vancomycin | nucleus accumbens |
SA051446 | 0040.d | HFD | vancomycin | nucleus accumbens |
SA051447 | 0041.d | HFD | vancomycin | nucleus accumbens |
SA051448 | 0029.d | HFD | vancomycin | nucleus accumbens |
SA051449 | 0027.d | HFD | vancomycin | nucleus accumbens |
SA051450 | 0033.d | HFD | vancomycin | nucleus accumbens |
SA051451 | 0067.d | HFD | vancomycin | plasma |
SA051452 | 0065.d | HFD | vancomycin | plasma |
SA051453 | 0064.d | HFD | vancomycin | plasma |
SA051454 | 0057.d | HFD | vancomycin | plasma |
SA051455 | 0051.d | HFD | vancomycin | plasma |
SA051456 | 0053.d | HFD | vancomycin | plasma |
Showing results 1 to 71 of 71 |