Summary of Study ST000890

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000619. The data can be accessed directly via it's Project DOI: 10.21228/M8NT1F This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study ID	ST000890
Study Title	Identification of RXR Ligands
Study Type	Idenfication of Ligands by HPLC-MS
Study Summary	Free fatty acids in mouse plasma were identified and quantified by LC-MS. Through differential feeding and PHZ (phnylhydrazine) dosing, coupled with mass spectrometry, we identified the long chain fatty acid C24:5 as a natural RXRA ligand, which was dynamically increased in concentration in response to hematopoietic stress. Collectively, these data demonstrate that natural RXRA ligands are present and are dynamically regulated in vivo in mouse hematopoietic cells.
Institute	Washington University in St. Louis
Department	Diabetic Cardiovascular Disease Center, School of Medicine
Laboratory	Metabolomics Core
Last Name	Fujiwara
First Name	Hideji
Address	660 South Euclid Ave, St. Louis MO 63110
Email	hfujiwar@wustl.edu
Phone	314-747-0494
Submit Date	2017-09-22
Study Comments	Units of measurement:peak area ratio: analyte peak area/peak area of internal standard
Analysis Type Detail	LC-MS
Release Date	2017-10-22
Release Version	1

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Factors:

Subject type: Animals; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id	local_sample_id	Diet of subject mice
SA052449	4630 BM2-PHZ	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052450	VADC-PHZ-4	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052451	4629 BM2-PHZ	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052452	4629 BM1-PHZ	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052453	VADC-PHZ-3	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052454	4630 PB1-PHZ	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052455	4630 BM1-PHZ	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052456	4629 PB1-PHZ	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052457	4630 PB2-PHZ	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052458	4629 PB2-PHZ	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052459	VADC-PHZ-1	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052460	VADC-PHZ-2	control chow \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052461	4633 PB1	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052462	VDAC41	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052463	VADC-23	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052464	VADC-13	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052465	VADC-33	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052466	VADC-43	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052467	VADC-53	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052468	VDAC52	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052469	VDAC42	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052470	VDAC21	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052471	VDAC51	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052472	VDAC22	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052473	VDAC32	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052474	4632 PB1	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052475	VDAC31	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052476	VADC-2	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052477	VADC-3	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052478	VADC-1	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052479	4632 PB2	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052480	4632 BM2	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052481	4633 PB2	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052482	VADC-4	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052483	4633 BM2	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052484	4632 BM1	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052485	4633 BM1	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052486	VADC-PHZ-5	control chow \| Feeding period (wk):12 \| PHZ dose (mg):mock
SA052487	NFC-PHZ-22	control chow \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052488	NFC-PHZ-23	control chow \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052489	NFC-PHZ-12	control chow \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052490	NFC-PHZ-21	control chow \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052491	NFC-PHZ-13	control chow \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052492	NFC-PHZ-11	control chow \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052493	FC-31	control chow \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052494	FC-21	control chow \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052495	FC-41	control chow \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052496	FC-12	control chow \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052497	FC-11	control chow \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052498	FC-42	control chow \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052499	FC-22	control chow \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052500	FC-32	control chow \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052418	NF-PHZ-41	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052419	NF-PHZ-31	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052420	NF-PHZ-32	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052421	NF-PHZ-23	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052422	NF-PHZ-43	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052423	NF-PHZ-21	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052424	NF-PHZ-42	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052425	NF-PHZ-33	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):1
SA052426	F-41	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052427	F-31	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052428	F-51	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052429	NF-11	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052430	NF-23	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052431	NF-33	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052432	F-21	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052433	F-11	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052434	NF-2	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052435	NF-3	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052436	NF-1	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052437	NF-31	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052438	NF-13	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052439	NF-12	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052440	NF-21	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052441	NF-22	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052442	NF-PHZ-22	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052443	F-12	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052444	F-52	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052445	NF-32	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052446	F-42	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052447	F-32	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052448	F-22	Non-fat-diet \| Feeding period (wk):4 \| PHZ dose (mg):mock
SA052501	VAD-PHZ2-32	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052502	VAD-PHZ2-12	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052503	VAD-PHZ2-42	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052504	VAD-PHZ2-22	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052505	VAD-PHZ1-11	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052506	VAD-PHZ1-31	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052507	VAD-PHZ1-21	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052508	VAD-PHZ2-52	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052509	VAD-PHZ1-41	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052510	VAD-PHZ2-51	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052511	VAD-PHZ1-42	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052512	VAD-PHZ1-22	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052513	VAD-PHZ2-41	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052514	VAD-PHZ2-31	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052515	VAD-PHZ2-11	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052516	VAD-PHZ2-21	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1
SA052517	VAD-PHZ1-12	vitamin A deficient diet \| Feeding period (wk):12 \| PHZ dose (mg):1