Summary of Study ST001527
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001028. The data can be accessed directly via it's Project DOI: 10.21228/M8T99V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001527 |
Study Title | Lung cancer metabolomics analysis |
Study Summary | This study explored models predictive of staging and chemotherapy response based on metabolomic analysis of fresh, patient-derived non-small cell lung cancer (NSCLC) core biopsies. Prospectively collected tissue samples before initial treatment were evaluated with high-resolution 2DLC-MS/MS and 13C-glucose enrichment, and the data were comprehensively analyzed with machine learning techniques. Patients were categorized as Disease-Control (DC) [encompassing complete-response (CR), partial-response (PR), and stable-disease (SD)] and Progressive-Disease (PD). Four major types of learning methods (partial least squares discriminant analysis (PLS-DA), support vector machines (SVM), artificial neural networks, and random forests) were applied to differentiate between positive (DC and CR/PR) and poor (PD and SD/PD) responses, and between stage I/II/III and stage IV disease. Models were trained with forward feature selection based on variable importance and tested on validation subsets. |
Institute | University of Louisville |
Department | Bioengineering |
Last Name | Frieboes |
First Name | Hermann |
Address | Lutz Hall 419 |
hbfrie01@louisville.edu | |
Phone | 502-852-3302 |
Submit Date | 2020-09-16 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2022-08-01 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Tumor_staging_before_chemo | Chemo_response_numeric |
---|---|---|---|
SA128667 | CDSR01292-01_neg | 1 | - |
SA128668 | N032_neg | 1 | - |
SA128669 | N023_pos | 1 | - |
SA128670 | N032_pos | 1 | - |
SA128671 | N023_neg | 1 | - |
SA128672 | CDSR01292-01_pos | 1 | - |
SA128673 | CDSR00861_01_pos | 1 | 1 |
SA128674 | CDSR00861_01_neg | 1 | 1 |
SA128675 | N026_pos | 1 | 1 |
SA128676 | N026_neg | 1 | 1 |
SA128677 | CDSR01154-01_pos | 1 | 3 |
SA128678 | CDSR01154-01_neg | 1 | 3 |
SA128679 | CDSR01257-01_pos | 2 | - |
SA128680 | CDSR01257-01_neg | 2 | - |
SA128681 | N039_neg | 2 | - |
SA128682 | N051_pos | 2 | - |
SA128683 | N039_pos | 2 | - |
SA128684 | N051_neg | 2 | - |
SA128685 | CDSR01092-01_pos | 2 | 1 |
SA128686 | CDSR01092-01_neg | 2 | 1 |
SA128687 | CDSR00877_01_pos | 2 | 2 |
SA128688 | CDSR00877_01_neg | 2 | 2 |
SA128689 | CDSR01563-01_pos | 3 | - |
SA128690 | CDSR01563-01_neg | 3 | - |
SA128691 | CDSR01197-01_pos | 3 | - |
SA128692 | CDSR01197-01_neg | 3 | - |
SA128693 | N010_neg | 3 | 2 |
SA128694 | N020_neg | 3 | 2 |
SA128695 | N020_pos | 3 | 2 |
SA128696 | N003_pos | 3 | 2 |
SA128697 | N003_neg | 3 | 2 |
SA128698 | N010_pos | 3 | 2 |
SA128699 | CDSR01256-01_pos | 3 | 3 |
SA128700 | CDSR01382-01_pos | 3 | 3 |
SA128701 | CDSR00894_01_neg | 3 | 3 |
SA128702 | CDSR01042_01_pos | 3 | 3 |
SA128703 | CDSR01042_01_neg | 3 | 3 |
SA128704 | N034_pos | 3 | 3 |
SA128705 | CDSR01382-01_neg | 3 | 3 |
SA128706 | N034_neg | 3 | 3 |
SA128707 | CDSR00894_01_pos | 3 | 3 |
SA128708 | CDSR01256-01_neg | 3 | 3 |
SA128709 | CDSR01155-01_neg | 3 | 4 |
SA128710 | CDSR01155-01_pos | 3 | 4 |
SA128711 | N045_neg | 4 | - |
SA128712 | N045_pos | 4 | - |
SA128713 | CDSR01405-01_neg | 4 | - |
SA128714 | CDSR01156-01_pos | 4 | - |
SA128715 | CDSR01405-01_pos | 4 | - |
SA128716 | CDSR01156-01_neg | 4 | - |
SA128717 | CDSR01177-01_pos | 4 | 2 |
SA128718 | N035_pos | 4 | 2 |
SA128719 | CDSR01177-01_neg | 4 | 2 |
SA128720 | N046_pos | 4 | 2 |
SA128721 | N018_pos | 4 | 2 |
SA128722 | N046_neg | 4 | 2 |
SA128723 | N035_neg | 4 | 2 |
SA128724 | N018_neg | 4 | 2 |
SA128725 | N004_pos | 4 | 3 |
SA128726 | CDSR01192-01_neg | 4 | 3 |
SA128727 | N004_neg | 4 | 3 |
SA128728 | CDSR01192-01_pos | 4 | 3 |
SA128729 | CDSR01023_01_pos | 4 | 4 |
SA128730 | CDSR01023_01_neg | 4 | 4 |
SA128731 | CDSR01291-01_pos | 4 | 4 |
SA128732 | CDSR01202-02_neg | 4 | 4 |
SA128733 | CDSR01202-02_pos | 4 | 4 |
SA128734 | CDSR01291-01_neg | 4 | 4 |
SA128663 | N030_neg | - | - |
SA128664 | N017_pos | - | - |
SA128665 | N017_neg | - | - |
SA128666 | N030_pos | - | - |
Showing results 1 to 72 of 72 |