Summary of Study ST001916
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001208. The data can be accessed directly via it's Project DOI: 10.21228/M8JX2X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001916 |
Study Title | Myocardial Rev-erb-mediated diurnal metabolic rhythm (Part 2/3) |
Study Summary | Agonists and antagonists of nuclear receptor Rev-erbα/β, key components of the circadian clock, can benefit the heart. Here, we show that mice with cardiomyocyte-specific knockout (KO) of Rev-erbα/β display progressive cardiac dilation and lethal heart failure. Inducible ablation of Rev-erbα/β in adult hearts causes similar phenotypes. Impaired fatty acid oxidation in the KO myocardium, particularly in the light cycle, precedes contractile dysfunctions with a reciprocal overreliance on carbohydrate utilization, particularly in the dark cycle. These findings delineate temporal coordination between clock-mediated anticipation and nutrient-induced response in myocardial metabolism. |
Institute | Baylor College of Medicine |
Last Name | Song |
First Name | Shiyang |
Address | One Baylor Plaza,Houston, TX, 77030 |
shiyangs@bcm.edu | |
Phone | 7137983159 |
Submit Date | 2021-09-10 |
Raw Data Available | Yes |
Analysis Type Detail | LC-MS |
Release Date | 2022-12-24 |
Release Version | 1 |
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Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
mb_sample_id | local_sample_id | Group | Genotype | Experimental variables |
---|---|---|---|---|
SA177718 | KO_CD_3 | KO_CD | Rev-erb cardiomyocyte specific knock out | heart ventrcle harvest from KO mouse fed with chow diet |
SA177719 | KO_CD_2 | KO_CD | Rev-erb cardiomyocyte specific knock out | heart ventrcle harvest from KO mouse fed with chow diet |
SA177720 | KO_CD_1 | KO_CD | Rev-erb cardiomyocyte specific knock out | heart ventrcle harvest from KO mouse fed with chow diet |
SA177715 | KO-HFHSD_2 | KO-HFHSD | Rev-erb cardiomyocyte specific knock out | heart ventrcle harvest from KOmouse fed with high fat high sucrose diet |
SA177716 | KO-HFHSD_3 | KO-HFHSD | Rev-erb cardiomyocyte specific knock out | heart ventrcle harvest from KOmouse fed with high fat high sucrose diet |
SA177717 | KO-HFHSD_1 | KO-HFHSD | Rev-erb cardiomyocyte specific knock out | heart ventrcle harvest from KOmouse fed with high fat high sucrose diet |
SA177721 | WT_CD_2 | WT_CD | wild type control | heart ventrcle harvest from WT mouse fed with chow diet |
SA177722 | WT_CD_3 | WT_CD | wild type control | heart ventrcle harvest from WT mouse fed with chow diet |
SA177723 | WT_CD_1 | WT_CD | wild type control | heart ventrcle harvest from WT mouse fed with chow diet |
SA177724 | WT_HFHSD_1 | WT_HFHSD | wild type control | heart ventrcle harvest from WT mouse fed with high fat high sucrose diet |
SA177725 | WT_HFHSD_2 | WT_HFHSD | wild type control | heart ventrcle harvest from WT mouse fed with high fat high sucrose diet |
SA177726 | WT_HFHSD_3 | WT_HFHSD | wild type control | heart ventrcle harvest from WT mouse fed with high fat high sucrose diet |
Showing results 1 to 12 of 12 |