Summary of Study ST002047
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001294. The data can be accessed directly via it's Project DOI: 10.21228/M8FQ39 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002047 |
Study Title | Lyso-lipid induced oligodendrocytes maturation underlie restoration of optic nerve function |
Study Summary | Protein hyper-deimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our in vitro studies show LPC 18:1 protection against neuron-ectopic hyper-deimination and stimulation of oligodendrocyte maturation, while in vivo investigations recorded optic nerve function improvement following optic nerve injections of LPC 18:1, in contrast to LPC 18:0. Thus just a change in a single bond renders a dramatic alternation in biological function. The incorporation of isobaric C13-histidine in newly synthesized myelin proteins and quantitative proteome shifts are consistent with remyelination underlying restoration in optic nerve function. These results suggest that exogenous LPC 18:1 may provide a therapeutic avenue for stemming vision loss in demyelinating diseases. |
Institute | University of Miami |
Last Name | Bhattacharya |
First Name | Sanjoy K. |
Address | 1638 NW 10th Avenue, Room 706-A, Miami, FL 33136 |
sbhattacharya@med.miami.edu | |
Phone | 3054824103 |
Submit Date | 2021-12-16 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2022-01-21 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Cultured cells; Subject species: Rattus norvegicus (Factor headings shown in green)
mb_sample_id | local_sample_id | Factor |
---|---|---|
SA192475 | OLGO_PP | Olig Over |
SA192476 | OLGO_PP_20210319014845 | Olig Over |
SA192477 | OLGO_PN | Olig Over |
SA192478 | OLGO_PN_20210318202010 | Olig Over |
SA192479 | OLGO_NP_20210318175410 | Olig Over |
SA192480 | OLGO_NP | Olig Over |
SA192481 | OLGO_NN_20210318164109 | Olig Over |
SA192482 | Olig_NNP_3_20210317032612 | Olig siRNA |
SA192483 | Olig_NPN_2 | Olig siRNA |
SA192484 | Olig_NPN_2_20210317010010 | Olig siRNA |
SA192485 | Olig_PNN_2 | Olig siRNA |
SA192486 | Olig_NNP_3 | Olig siRNA |
SA192487 | Olig_NNN_2 | Olig siRNA |
SA192488 | Olig_PNN_2_20210317112047 | Olig siRNA |
SA192489 | Olig_NNN_2_20210317100746 | Olig siRNA |
SA192490 | Olig_NNP_2 | Olig siRNA |
SA192491 | Olig_NNP_2_20210317074144 | Olig siRNA |
SA192492 | Olig_PPP_2 | Olig siRNA |
SA192493 | Olig_PPP_2_20210317043913 | Olig siRNA |
SA192457 | OPCO_PN | OPC Over |
SA192458 | OPCO_PN_20210318232241 | OPC Over |
SA192459 | OPCO_PP_20210318190709 | OPC Over |
SA192460 | OPCO_NP_20210319003544 | OPC Over |
SA192461 | OPCO_PP | OPC Over |
SA192462 | OPCO_NP | OPC Over |
SA192463 | OPCO_NN | OPC Over |
SA192464 | OPCO_NN_20210318220941 | OPC Over |
SA192465 | OPC_PNN_1 | OPC siRNA |
SA192466 | OPC_PNN_1_20210317134649 | OPC siRNA |
SA192467 | OPC_NPN_1_20210317021311 | OPC siRNA |
SA192468 | OPC_PPP_1 | OPC siRNA |
SA192469 | OPC_NNP_1 | OPC siRNA |
SA192470 | OPC_PPP_1_20210317055214 | OPC siRNA |
SA192471 | OPC_NNN_1_20210317085445 | OPC siRNA |
SA192472 | OPC_NNP_1_20210317123348 | OPC siRNA |
SA192473 | OPC_NPN_1 | OPC siRNA |
SA192474 | OPC_NNN_1 | OPC siRNA |
SA192494 | RGC_over_NP | RGC Over |
SA192495 | RGC_over_PN | RGC Over |
SA192496 | repRGC_over_NN | RGC Over |
SA192497 | RGC_over_NN | RGC Over |
SA192498 | repRGC_over_PN | RGC Over |
SA192499 | repRGC_over_NP | RGC Over |
SA192500 | RGC_over_PP | RGC Over |
SA192501 | repRGC_over_PP | RGC Over |
SA192502 | RGC_si_PNN | RGC siRNA |
SA192503 | repRGC_si_NNN | RGC siRNA |
SA192504 | RGC_si_NNN | RGC siRNA |
SA192505 | RGC_si_NNP | RGC siRNA |
SA192506 | RGC_si_NPN | RGC siRNA |
SA192507 | repRGC_si_PPP | RGC siRNA |
SA192508 | repRGC_si_PNN | RGC siRNA |
SA192509 | repRGC_si_NNP | RGC siRNA |
SA192510 | repRGC_si_NPN | RGC siRNA |
SA192511 | RGC_si_PPP | RGC siRNA |
Showing results 1 to 55 of 55 |