Summary of Study ST002161

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001374. The data can be accessed directly via it's Project DOI: 10.21228/M84127 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002161
Study TitleGlycerate Production from Intestinal Fructose Metabolism Elevated by Dietary Fat Induces Glucose Intolerance Through β-cell Damage
Study SummaryDietary fructose, especially in the context of a high-fat western diet, has been linked to type 2 diabetes. Although the effect of fructose on liver metabolism has been extensively studied, a significant portion of the fructose is first metabolized in the small intestine. Here we report that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood. High systemic glycerate levels reduce pancreatic islet sizes and β-cell content, thus inducing glucose intolerance. Our findings provide an additional link between dietary fructose and diabetes that is modulated by dietary fat.
Institute
Duke University
Last NameWong
First NameChi Wut
AddressCEIMAS, 101 Science Dr. Room 2141, Durham, NC, 27709, USA
Emailchiwut.wong@duke.edu
Phone9495290320
Submit Date2022-05-11
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailLC-MS
Release Date2022-07-06
Release Version1
Chi Wut Wong Chi Wut Wong
https://dx.doi.org/10.21228/M84127
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Genotype
SA207163Blank_batch4Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207164Blank_batch3Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207165Blank_batch11Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207166Blank_batch5Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207167Blank_batch2Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207168Blank_batch6Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207169Blank_batch9Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207170Blank_batch8Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207171Blank_batch7Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207172Blank_batch10Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207173Blank_batch1Blank | Diet:Blank | Diet Duration:Blank | Treatment:Blank | Tissue:Blank | Collection Time (minute):Blank | Drinking:Blank
SA207177KHK_Gly_5_010KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA207178KHK_Gly_4_010KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA207179KHK_Gly_1_010KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA207180KHK_Gly_5_120KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water
SA207181KHK_Gly_4_120KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water
SA207182KHK_Gly_1_120KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water
SA207183KHK_Gly_5_030KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water
SA207184KHK_Gly_1_030KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water
SA207185KHK_Gly_4_030KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water
SA207186KHK_Gly_5_060KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water
SA207187KHK_Gly_1_060KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water
SA207188KHK_Gly_4_060KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water
SA207174KHK_Gly_4_000KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water
SA207175KHK_Gly_1_000KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water
SA207176KHK_Gly_5_000KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water
SA207189Unlabeled_LF-HV_6348Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207190Unlabeled_LF-HV_13628Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207191Unlabeled_LF-HV_13626Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207192Unlabeled_LF-HV_13631Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207193Unlabeled_LF-HV_13627Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207194Unlabeled_LH-HV_10632Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207195Unlabeled_LH-HV_916Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207196Unlabeled_LH-HV_10684Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207197Unlabeled_LH-HV_914Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207198Unlabeled_LH-HV_917Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207199Unlabeled_LC-HV_13646Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207200Unlabeled_LC-HV_13683Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207201Unlabeled_LC-HV_13637Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207202Unlabeled_LC-HV_13635Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207203Unlabeled_LC-HV_13642Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207204Unlabeled_LC-HV_13634Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water
SA207205Jej-13172Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water
SA207206Intestine_01Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water
SA207207Jej-13170Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water
SA207208Jej-13171Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water
SA207213L12130_45_02Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water
SA207214L12126_45_02Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water
SA207215L12129_45_02Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water
SA207216L12128_45_02Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water
SA207217L12140_60_03Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water
SA207218L12137_60_03Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water
SA207219L12139_60_03Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water
SA207220L12136_60_03Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water
SA207209L13157_0_01Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water
SA207210L13160_0_01Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water
SA207211L13159_0_01Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water
SA207212L13156_0_01Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water
SA20722413C-Fruc_LFD-PV_13171Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water
SA20722513C-Fruc_LFD-PV_13170Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water
SA20722613C-Fruc_LFD-PV_13172Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water
SA20722713C-Fruc_LFD-PV_13168Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water
SA20722813C-Fruc_LFD-PV_13169Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water
SA207229CON-PV_120_12156Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water
SA207230CON-PV_120_12158Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water
SA207231CON-PV_120_12157Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water
SA207232CON-PV_15_12107Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water
SA207233CON-PV_15_12106Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water
SA207234CON-PV_15_12109Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water
SA207235CON-PV_15_12110Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water
SA207236CON-PV_15_12108Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water
SA207237CON-PV_30_12118Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water
SA207238CON-PV_30_12116Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water
SA207239CON-PV_30_12117Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water
SA207240CON-PV_30_12119Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water
SA207241CON-PV_30_12120Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water
SA207242CON-PV_45_12126Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water
SA207243CON-PV_45_12127Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water
SA207244CON-PV_45_12128Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water
SA207245CON-PV_45_12129Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water
SA207246CON-PV_45_12130Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water
SA207247CON-PV_60_12136Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water
SA207248CON-PV_60_12139Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water
SA207249CON-PV_60_12137Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water
SA207250CON-PV_60_12140Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water
SA207251CON-PV_60_12138Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water
SA207252CON-PV_90_12146Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water
SA207253CON-PV_90_12148Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water
SA207254CON-PV_90_12147Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water
SA207221CON-PV_0_13158Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water
SA207222CON-PV_0_13157Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water
SA207223CON-PV_0_13156Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water
SA20726113C-Fruc_LFD-HV_13171Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA20726213C-Fruc_LFD-HV_13170Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA20726313C-Fruc_LFD-HV_13169Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA207264KHK_Gly_6_010Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA207265KHK_Gly_3_010Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA207266KHK_Gly_2_010Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA20726713C-Fruc_LFD-HV_13168Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
SA20726813C-Fruc_LFD-HV_13172Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water
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