Summary of Study ST002214
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001414. The data can be accessed directly via it's Project DOI: 10.21228/M8Z42Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002214 |
Study Title | The effects of PKM2 modulation and hypoxia on the metabolic landscape of Alzheimer patient-derived induced neurons |
Study Summary | We have obtained fibroblast cultures from old adult human non-demented control donors and Alzheimer patients (AD). The fibroblasts were reprogrammed into directly induced neurons (iNs) to serve as an adult-like and age-equivalent model for aging and neurodegeneration. Their response to PKM2 modulation (shikonin 10 µM or PKM2 overexpression) and hypoxia (CoDo treatment) were assessed. |
Institute | University of Colorado Denver |
Last Name | Haines |
First Name | Julie |
Address | 12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA |
julie.haines@cuanschutz.edu | |
Phone | 3037243339 |
Submit Date | 2022-06-24 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2022-07-25 |
Release Version | 1 |
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Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Condition | Treatment |
---|---|---|---|
SA211868 | 8020-C | Alzheimer patient | DMSO |
SA211869 | 3131-C | Alzheimer patient | DMSO |
SA211870 | 3053-C | Alzheimer patient | DMSO |
SA211871 | 2800-C | Alzheimer patient | DMSO |
SA211872 | 2800-S | Alzheimer patient | Shikonin |
SA211873 | 8020-S | Alzheimer patient | Shikonin |
SA211874 | 3053-S | Alzheimer patient | Shikonin |
SA211875 | 3131-S | Alzheimer patient | Shikonin |
SA211876 | 8011-DFO | non-demented control | CoDo Treatment |
SA211877 | 2785-DFO | non-demented control | CoDo Treatment |
SA211878 | 2785-C | non-demented control | GFP-overexpression |
SA211879 | 2608-C | non-demented control | GFP-overexpression |
SA211880 | 8011-C | non-demented control | GFP-overexpression |
SA211881 | 2608-OE | non-demented control | PKM2-overexpression |
SA211882 | 2785-OE | non-demented control | PKM2-overexpression |
SA211883 | 8011-OE | non-demented control | PKM2-overexpression |
Showing results 1 to 16 of 16 |