Summary of Study ST002479
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001599. The data can be accessed directly via it's Project DOI: 10.21228/M8113P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002479 |
Study Title | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Hamster) |
Study Summary | While a common symptom of influenza and coronavirus disease 2019 (COVID-19) is fever, its physiological role on host resistance to viral infection remains less clear. Here, we demonstrate that exposure of mice to the high ambient temperature of 36 °C increase host resistance to viral pathogens including influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). High heat-exposed mice increase basal body temperature over 38 °C to enable more bile acids production in a gut microbiota-dependent manner. The gut microbiota-derived deoxycholic acid (DCA) and its plasma membrane-bound receptor Takeda G-protein-coupled receptor 5 (TGR5) signaling increase host resistance to influenza virus infection by suppressing virus replication and neutrophil-dependent tissue damage. Furthermore, the DCA and its nuclear farnesoid X receptor (FXR) agonist protect Syrian hamster from lethal SARS-CoV-2 infection. Moreover, we demonstrate that certain bile acids are reduced in the plasma of COVID-19 patients who developed moderate I/II disease compared with minor illness group. These findings uncover an unexpected mechanism by which virus-induced high fever increases host resistance to influenza virus and SARS-CoV-2 in a gut microbiota-dependent manner. |
Institute | Keio University |
Last Name | Fukuda |
First Name | Shinji |
Address | Kakuganji 246-2, Mizukami, Tsuruoka City Yamagata,Japan |
sfukuda@sfc.keio.ac.jp | |
Phone | +81-235-29-800 |
Submit Date | 2023-02-14 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | CE-MS |
Release Date | 2023-03-10 |
Release Version | 2 |
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Factors:
Subject type: Mammal; Subject species: Mesocricetus Auratus (Factor headings shown in green)
mb_sample_id | local_sample_id | Temperature |
---|---|---|
SA249058 | 15 | 22 ℃ for 7 d |
SA249059 | 14 | 22 ℃ for 7 d |
SA249060 | 13 | 22 ℃ for 7 d |
SA249061 | 16 | 22 ℃ for 7 d |
SA249062 | 18 | 22 ℃ for 7 d |
SA249063 | 20 | 22 ℃ for 7 d |
SA249064 | 19 | 22 ℃ for 7 d |
SA249065 | 12 | 22 ℃ for 7 d |
SA249066 | 17 | 22 ℃ for 7 d |
SA249067 | 11 | 22 ℃ for 7 d |
SA249068 | 5 | 4 ℃ for 7 d |
SA249069 | 4 | 4 ℃ for 7 d |
SA249070 | 3 | 4 ℃ for 7 d |
SA249071 | 2 | 4 ℃ for 7 d |
SA249072 | 6 | 4 ℃ for 7 d |
SA249073 | 7 | 4 ℃ for 7 d |
SA249074 | 10 | 4 ℃ for 7 d |
SA249075 | 9 | 4 ℃ for 7 d |
SA249076 | 8 | 4 ℃ for 7 d |
SA249077 | 1 | 4 ℃ for 7 d |
Showing results 1 to 20 of 20 |