Summary of Study ST002581

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002581
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Plasma - Targeted Keto Acids
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Duke University
Department	Duke Molecular Physiology Institute
Laboratory	Metabolomics Core Laboratory
Last Name	Newgard
First Name	Christopher
Address	300 N Duke St, Durham, NC 27701
Email	chris.newgard@duke.edu
Phone	(919) 668-6059
Submit Date	2023-04-25
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA258978	90252013108	Control	8 weeks of training or control time	Female
SA258979	90265013108	Control	8 weeks of training or control time	Female
SA258980	90245013108	Control	8 weeks of training or control time	Female
SA258981	90248013108	Control	8 weeks of training or control time	Female
SA258982	90266013108	Control	8 weeks of training or control time	Female
SA258983	90239013108	Control	8 weeks of training or control time	Male
SA258984	90229013108	Control	8 weeks of training or control time	Male
SA258985	90232013108	Control	8 weeks of training or control time	Male
SA258986	90237013108	Control	8 weeks of training or control time	Male
SA258987	90217013108	Control	8 weeks of training or control time	Male
SA258988	80015823102_4	QC-ExternalStandard	0 hour	-
SA258989	80015823102_2	QC-ExternalStandard	0 hour	-
SA258990	80014813102_4	QC-ExternalStandard	0 hour	-
SA258991	80015823102_3	QC-ExternalStandard	0 hour	-
SA258992	80014813102_3	QC-ExternalStandard	0 hour	-
SA258993	80014813102_2	QC-ExternalStandard	0 hour	-
SA258995	80015823102_1	QC-ExternalStandard	0 hour	-
SA258994	80014813102_1	QC-ExternalStandard	0 hour	-	-
SA258996	90560013108	Training	1 week of training or control time	Female
SA258997	90567013108	Training	1 week of training or control time	Female
SA258998	90564013108	Training	1 week of training or control time	Female
SA258999	90559013108	Training	1 week of training or control time	Female
SA259000	90571013108	Training	1 week of training or control time	Female
SA259001	90430013108	Training	1 week of training or control time	Male
SA259002	90426013108	Training	1 week of training or control time	Male
SA259003	90422013108	Training	1 week of training or control time	Male
SA259004	90421013108	Training	1 week of training or control time	Male
SA259005	90423013108	Training	1 week of training or control time	Male
SA259006	90576013108	Training	2 weeks of training	Female
SA259007	90587013108	Training	2 weeks of training	Female
SA259008	90578013108	Training	2 weeks of training	Female
SA259009	90585013108	Training	2 weeks of training	Female
SA259010	90581013108	Training	2 weeks of training	Female
SA259011	90450013108	Training	2 weeks of training	Male
SA259012	90441013108	Training	2 weeks of training	Male
SA259013	90439013108	Training	2 weeks of training	Male
SA259014	90449013108	Training	2 weeks of training	Male
SA259015	90444013108	Training	2 weeks of training	Male
SA259016	90406013108	Training	4 weeks of training	Female
SA259017	90420013108	Training	4 weeks of training	Female
SA259018	90410013108	Training	4 weeks of training	Female
SA259019	90412013108	Training	4 weeks of training	Female
SA259020	90416013108	Training	4 weeks of training	Female
SA259021	90280013108	Training	4 weeks of training	Male
SA259022	90281013108	Training	4 weeks of training	Male
SA259023	90292013108	Training	4 weeks of training	Male
SA259024	90289013108	Training	4 weeks of training	Male
SA259025	90283013108	Training	4 weeks of training	Male
SA259026	90259013108	Training	8 weeks of training or control time	Female
SA259027	90254013108	Training	8 weeks of training or control time	Female
SA259028	90267013108	Training	8 weeks of training or control time	Female
SA259029	90258013108	Training	8 weeks of training or control time	Female
SA259030	90251013108	Training	8 weeks of training or control time	Female
SA259031	90222013108	Training	8 weeks of training or control time	Male
SA259032	90218013108	Training	8 weeks of training or control time	Male
SA259033	90225013108	Training	8 weeks of training or control time	Male
SA259034	90223013108	Training	8 weeks of training or control time	Male
SA259035	90227013108	Training	8 weeks of training or control time	Male

Showing results 1 to 58 of 58

Showing results 1 to 58 of 58