Summary of Study ST002764
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001722. The data can be accessed directly via it's Project DOI: 10.21228/M8441W This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002764 |
Study Title | Identification of pre-diagnostic lipid sets associated with liver cancer risk using untargeted lipidomics and chemical set analysis – a nested case-control study within the ATBC cohort |
Study Summary | In pre-disposed individuals, a reprogramming of the hepatic lipid metabolism may support liver cancer initiation. We conducted a high-resolution mass spectrometry based untargeted lipidomics analysis of pre-diagnostic serum samples from a nested case-control study (219 liver cancer cases and 219 controls) within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Out of 462 annotated lipids, 158 (34.2%) were associated with liver cancer risk in a conditional logistic regression analysis at a false discovery rate (FDR) < 0.05. A chemical set enrichment analysis (ChemRICH) and co-regulatory set analysis suggested that 22/28 lipid classes and 47/83 correlation modules were significantly associated with liver cancer risk (FDR <0.05). Strong positive associations were observed for monounsaturated fatty acids (MUFA), triacylglycerols (TAGs), and phosphatidylcholines (PCs) having MUFA acyl chains. Negative associations were observed for sphingolipids (ceramides and sphingomyelins), lysophosphatidylcholines, cholesterol esters and polyunsaturated fatty acids (PUFA) containing TAGs and PCs. Stearoyl-CoA desaturase enzyme 1 (SCD1), a rate limiting enzyme in fatty acid metabolism and ceramidases seems to be critical in this reprogramming. In conclusion, our study reports pre-diagnostic lipid changes that provide novel insights into hepatic lipid metabolism reprogramming may contribute to a pro-cell growth and anti-apoptotic tissue environment and, in turn, support liver cancer initiation. Study |
Institute | Icahn School of Medicine at Mount Sinai |
Department | Environmental Medicine and Public Health |
Laboratory | Integrated Data Science Laboratory for Metabolomics and Exposomics |
Last Name | Barupal |
First Name | Dinesh |
Address | CAM Building 102street |
dinesh.barupal@mssm.edu | |
Phone | 5309794354 |
Submit Date | 2023-06-28 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzML |
Analysis Type Detail | LC-MS |
Release Date | 2023-07-03 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | liver_cancer_outcome |
---|---|---|
SA291702 | BPL1415 0873 | Case |
SA291703 | BPL1415 0874 | Case |
SA291704 | BPL1415 0689 | Case |
SA291705 | BPL1415 0691 | Case |
SA291706 | BPL1415 0694 | Case |
SA291707 | BPL1415 0686 | Case |
SA291708 | BPL1415 0870 | Case |
SA291709 | BPL1415 0683 | Case |
SA291710 | BPL1415 0878 | Case |
SA291711 | BPL1415 0675 | Case |
SA291712 | BPL1415 0678 | Case |
SA291713 | BPL1415 0679 | Case |
SA291714 | BPL1415 0696 | Case |
SA291715 | BPL1415 0876 | Case |
SA291716 | BPL1415 0685 | Case |
SA291717 | BPL1415 0699 | Case |
SA291718 | BPL1415 0861 | Case |
SA291719 | BPL1415 0711 | Case |
SA291720 | BPL1415 0713 | Case |
SA291721 | BPL1415 0714 | Case |
SA291722 | BPL1415 0718 | Case |
SA291723 | BPL1415 0860 | Case |
SA291724 | BPL1415 0709 | Case |
SA291725 | BPL1415 0863 | Case |
SA291726 | BPL1415 0867 | Case |
SA291727 | BPL1415 0880 | Case |
SA291728 | BPL1415 0702 | Case |
SA291729 | BPL1415 0865 | Case |
SA291730 | BPL1415 0707 | Case |
SA291731 | BPL1415 0705 | Case |
SA291732 | BPL1415 0697 | Case |
SA291733 | BPL1415 0672 | Case |
SA291734 | BPL1415 0643 | Case |
SA291735 | BPL1415 0896 | Case |
SA291736 | BPL1415 0644 | Case |
SA291737 | BPL1415 0895 | Case |
SA291738 | BPL1415 0892 | Case |
SA291739 | BPL1415 0646 | Case |
SA291740 | BPL1415 0641 | Case |
SA291741 | BPL1415 0639 | Case |
SA291742 | BPL1415 0901 | Case |
SA291743 | BPL1415 0630 | Case |
SA291744 | BPL1415 0632 | Case |
SA291745 | BPL1415 0633 | Case |
SA291746 | BPL1415 0636 | Case |
SA291747 | BPL1415 0899 | Case |
SA291748 | BPL1415 0811 | Case |
SA291749 | BPL1415 0652 | Case |
SA291750 | BPL1415 0665 | Case |
SA291751 | BPL1415 0885 | Case |
SA291752 | BPL1415 0666 | Case |
SA291753 | BPL1415 0883 | Case |
SA291754 | BPL1415 0671 | Case |
SA291755 | BPL1415 0669 | Case |
SA291756 | BPL1415 0662 | Case |
SA291757 | BPL1415 0661 | Case |
SA291758 | BPL1415 0889 | Case |
SA291759 | BPL1415 0654 | Case |
SA291760 | BPL1415 0657 | Case |
SA291761 | BPL1415 0658 | Case |
SA291762 | BPL1415 0887 | Case |
SA291763 | BPL1415 0719 | Case |
SA291764 | BPL1415 0722 | Case |
SA291765 | BPL1415 0781 | Case |
SA291766 | BPL1415 0828 | Case |
SA291767 | BPL1415 0826 | Case |
SA291768 | BPL1415 0783 | Case |
SA291769 | BPL1415 0785 | Case |
SA291770 | BPL1415 0825 | Case |
SA291771 | BPL1415 0778 | Case |
SA291772 | BPL1415 0777 | Case |
SA291773 | BPL1415 0768 | Case |
SA291774 | BPL1415 0834 | Case |
SA291775 | BPL1415 0769 | Case |
SA291776 | BPL1415 0831 | Case |
SA291777 | BPL1415 0774 | Case |
SA291778 | BPL1415 0772 | Case |
SA291779 | BPL1415 0788 | Case |
SA291780 | BPL1415 0789 | Case |
SA291781 | BPL1415 0802 | Case |
SA291782 | BPL1415 0816 | Case |
SA291783 | BPL1415 0804 | Case |
SA291784 | BPL1415 0806 | Case |
SA291785 | BPL1415 0808 | Case |
SA291786 | BPL1415 0814 | Case |
SA291787 | BPL1415 0800 | Case |
SA291788 | BPL1415 0817 | Case |
SA291789 | BPL1415 0791 | Case |
SA291790 | BPL1415 0823 | Case |
SA291791 | BPL1415 0820 | Case |
SA291792 | BPL1415 0794 | Case |
SA291793 | BPL1415 0797 | Case |
SA291794 | BPL1415 0796 | Case |
SA291795 | BPL1415 0765 | Case |
SA291796 | BPL1415 0763 | Case |
SA291797 | BPL1415 0735 | Case |
SA291798 | BPL1415 0849 | Case |
SA291799 | BPL1415 0736 | Case |
SA291800 | BPL1415 0738 | Case |
SA291801 | BPL1415 0741 | Case |