Summary of Study ST003177

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001976. The data can be accessed directly via it's Project DOI: 10.21228/M89J06 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003177
Study TitleA Longitudinal Study in Rheumatoid Arthritis Unveils Metabolomic Biomarkers Preceding Clinical Onset, Assessing Disease Severity, and Anticipating Treatment Response to csDMARDs
Study SummaryRheumatoid arthritis (RA) is a bundle of systemic inflammatory diseases mainly affecting the joints, complicating the identification of biomarkers for early diagnosis, predicting disease progress and therapeutic outcomes. This study scrutinizes a longitudinal cohort of RA, inclusive of follow-ups, alongside OA, UA and ACPA/RF-RA and healthy controls, aiming to discover plasma metabolic markers that can precede RA onset, assess disease activity, and forecast treatment efficacy. Our investigation revealed substantial metabolic alterations at both the pathway and individual metabolite levels across RA, at-risk or RA and healthy control. The drug response predictive models constructed on critical differential metaboites showed optimal performance. Additionally, our longitudinal data sheds light on the molecular impacts on metabolism of csDMARDs in RA.
Institute
West China Hospital of Sichuan University
Last NameZhu
First NameChenxi
AddressWest China Hospital, Sichuan University, 37# Guoxue Xiang, Chengdu, Sichuan, 610041, China.
Emailchenxizhu1995@gmail.com
Phone+8615026603760
Submit Date2024-04-12
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-05-11
Release Version1
Chenxi Zhu Chenxi Zhu
https://dx.doi.org/10.21228/M89J06
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Clinical group Sample source
SA343818NEG_140CCP-RA blood
SA343819POS_475CCP-RA blood
SA343820NEG_226CCP-RA blood
SA343821NEG_560CCP-RA blood
SA343822POS_637CCP-RA blood
SA343823POS_226CCP-RA blood
SA343824POS_987CCP-RA blood
SA343825POS_140CCP-RA blood
SA343826POS_472CCP-RA blood
SA343827NEG_475CCP-RA blood
SA343828NEG_464CCP-RA blood
SA343829NEG_461CCP-RA blood
SA343830POS_980CCP-RA blood
SA343831POS_310CCP-RA blood
SA343832POS_560CCP-RA blood
SA343833NEG_980CCP-RA blood
SA343834NEG_472CCP-RA blood
SA343835NEG_987CCP-RA blood
SA343836POS_464CCP-RA blood
SA343837NEG_310CCP-RA blood
SA343838POS_461CCP-RA blood
SA343839NEG_637CCP-RA blood
SA345220NEG_942health blood
SA345221POS_113health blood
SA345222POS_624health blood
SA345223POS_17health blood
SA345224POS_109health blood
SA345225POS_281health blood
SA345226POS_942health blood
SA345227POS_279health blood
SA345228POS_915health blood
SA345229NEG_965health blood
SA345230POS_923health blood
SA345231POS_947health blood
SA345232POS_931health blood
SA345233POS_11health blood
SA345234POS_619health blood
SA345235NEG_958health blood
SA345236POS_611health blood
SA345237POS_605health blood
SA345238NEG_961health blood
SA345239NEG_947health blood
SA345240POS_548health blood
SA345241POS_991health blood
SA345242POS_621health blood
SA345243POS_926health blood
SA345244POS_550health blood
SA345245POS_733health blood
SA345246POS_111health blood
SA345247NEG_977health blood
SA345248POS_976health blood
SA345249POS_540health blood
SA345250POS_975health blood
SA345251POS_974health blood
SA345252POS_973health blood
SA345253POS_977health blood
SA345254NEG_902health blood
SA345255POS_105health blood
SA345256POS_719health blood
SA345257POS_541health blood
SA345258NEG_11health blood
SA345259POS_288health blood
SA345260POS_726health blood
SA345261POS_972health blood
SA345262POS_724health blood
SA345263POS_965health blood
SA345264POS_722health blood
SA345265POS_580health blood
SA345266NEG_33health blood
SA345267POS_967health blood
SA345268POS_577health blood
SA345269NEG_17health blood
SA345270POS_971health blood
SA345271POS_970health blood
SA345272POS_720health blood
SA345273NEG_26health blood
SA345274POS_542health blood
SA345275POS_728health blood
SA345276NEG_974health blood
SA345277NEG_973health blood
SA345278NEG_975health blood
SA345279NEG_976health blood
SA345280NEG_926health blood
SA345281NEG_931health blood
SA345282NEG_972health blood
SA345283NEG_967health blood
SA345284POS_545health blood
SA345285NEG_970health blood
SA345286NEG_971health blood
SA345287POS_732health blood
SA345288POS_629health blood
SA345289NEG_923health blood
SA345290POS_285health blood
SA345291POS_543health blood
SA345292NEG_991health blood
SA345293POS_982health blood
SA345294POS_981health blood
SA345295NEG_915health blood
SA345296POS_983health blood
SA345297NEG_982health blood
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