Summary of Study ST003193

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001989. The data can be accessed directly via it's Project DOI: 10.21228/M8MT61 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003193
Study TitleMetabolomics study on frozen tissue derived from the tumor and adjacent non-malignant liver tissue (NML) of patient afflicted with fibrolamellar carinoma (FLC)
Study TypeLC-MS quantitative analysis
Study SummaryFibrolamellar carcinoma (FLC) is a rare, early-onset liver cancer. The five-year survival rate is low, and there is a critical need for new therapeutics. The primary driver in FLC is the fusion oncoprotein, DNAJ-PKAc, which remains challenging to target therapeutically. It is critical, therefore, to expand understanding of the FLC molecular landscape to identify druggable pathways/targets. To date, only one study has attempted to characterize the FLC proteome and metabolome, but with modest sample size (proteomics—n = 16 patient samples; metabolomics—n = 10 patient samples) and protein detection (n = 4620 proteins). We have performed the most comprehensive characterization of FLC in both proteomics (n = 23 patient samples; n = 8485 proteins) and metabolomics (n = 26 patient samples; n = 135 metabolites). Targeted metabolomics on central carbon metabolism (polar metabolite extraction) was performed followed by extensive quantitative and qualitative assessment of its relationship with the proteome of FLC to gain insight on how the metabolic network is constructed in this cancer. Frozen patient tissue was derived from both primary and metastatic tumors as well as adjacent non-malignant liver tissue (NML). Primary and metastatic tumors served as our FLC cohort while NMLs served as our control cohort.
Institute
Cornell University
DepartmentBiomedical Sciences
LaboratoryPraveen Sethupathy
Last NameLong Jr.
First NameDonald
Address618 Tower Road, Ithaca, New York, 14853, USA
Emaildl964@cornell.edu
Phone4355312013
Submit Date2024-05-06
Num Groups2
Total Subjects26
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-05-29
Release Version1
Donald Long Jr. Donald Long Jr.
https://dx.doi.org/10.21228/M8MT61
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Cohort Tissue Classification (via Physician)
SA347909FLC06_DZISLiver FLC Met
SA347910FLC15_AWTJLiver FLC Met
SA347911FLC11_WHAYLiver FLC Pri
SA347912FLC07_LFOCLiver FLC Pri
SA347913FCF58_TLiver FLC Pri
SA347914FCF82_TLiver FLC Pri
SA347915FCF56_TLiver FLC Pri
SA347916FCF83_TLiver FLC Pri
SA347917FLC24_DJZWLiver FLC Pri
SA347918FLC26_YJEELiver FLC Pri
SA347919FLC18_MKZCLiver FLC Pri
SA347920FCF83_NLiver NML NML
SA347921FCF82_NLiver NML NML
SA347922FCF84_NLiver NML NML
SA347923FLC34_PMVVLiver NML NML
SA347924FLC27_BWSXLiver NML NML
SA347925FLC26_ICBQLiver NML NML
SA347926FLC33_NYTSLung FLC Met
SA347927FLC29_QLXWLung FLC Met
SA347928FLC20_ZDNVLymph Node FLC Met
SA347929FLC25_UYHRLymph Node FLC Met
SA347930FLC28_RKXKLymph Node FLC Met
SA347931FLC27_XDGPLymph Node FLC Met
SA347932FLC31_OTOKLymph Node FLC Met
SA347933FLC30_KPKSPeritoneal FLC Met
SA347934FLC14_EQPRSpinal FLC Met
Showing results 1 to 26 of 26
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