Summary of Study ST003215

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002005. The data can be accessed directly via it's Project DOI: 10.21228/M8FJ9V This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003215
Study TitleProtein restriction slows the development and progression of Alzheimer's disease in mice
Study SummaryDietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and many independent groups of researchers have shown that dietary protein restriction (PR) extends the lifespan and healthspan of mice. Here, we examined the effect of PR on metabolic health and the development and progression of Alzheimer’s disease (AD) in the 3xTg mouse model of AD. We found that PR has metabolic benefits for 3xTg mice and non-transgenic controls of both sexes, promoting leanness and glycemic control in 3xTg mice and rescuing the glucose intolerance of 3xTg females. We found that PR induces sex-specific alterations in circulating metabolites and in the brain lipidome, downregulating sphingolipid subclasses including ceramides, glucosylceramides, and sphingomyelins in 3xTg females. Consumption of a PR diet starting at 6 months of age reduced AD pathology in conjunction with reduced mTORC1 activity, increased autophagy, and had cognitive benefits for 3xTg mice. Finally, PR improved the survival of 3xTg mice. Our results demonstrate that PR slows the progression of AD at molecular and pathological levels, preserves cognition in this mouse model of AD, and suggests that PR or pharmaceutical interventions that mimic the effects of this diet may hold promise as a treatment for AD.
Institute
University of Wisconsin-Madison
Last NameSimcox
First NameJudith
Address433 Babcock Dr, Madison, WI, 53706, USA
Emailjsimcox@wisc.edu
Phone-
Submit Date2024-05-20
Total Subjects40
Num Males20
Num Females20
Raw Data AvailableYes
Raw Data File Type(s)mzdata.xml
Analysis Type DetailLC-MS
Release Date2024-06-12
Release Version1
Judith Simcox Judith Simcox
https://dx.doi.org/10.21228/M8FJ9V
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Genotype Treatment
SA351738F13Brain 3xTg Control
SA351739F11Brain 3xTg Control
SA351740F14Brain 3xTg Control
SA351741M12Brain 3xTg Control
SA351742M11Brain 3xTg Control
SA351743M13Brain 3xTg Control
SA351744F15Brain 3xTg Control
SA351745F12Brain 3xTg Control
SA351746M14Brain 3xTg Control
SA351747M15Brain 3xTg Control
SA351748F19Brain 3xTg Protein restriction
SA351749F20Brain 3xTg Protein restriction
SA351750M19Brain 3xTg Protein restriction
SA351751M20Brain 3xTg Protein restriction
SA351752F18Brain 3xTg Protein restriction
SA351753F16Brain 3xTg Protein restriction
SA351754M16Brain 3xTg Protein restriction
SA351755F17Brain 3xTg Protein restriction
SA351756M17Brain 3xTg Protein restriction
SA351757M18Brain 3xTg Protein restriction
SA351758M5Brain Non-transgenic Control
SA351759M4Brain Non-transgenic Control
SA351760M1Brain Non-transgenic Control
SA351761F1Brain Non-transgenic Control
SA351762M3Brain Non-transgenic Control
SA351763M2Brain Non-transgenic Control
SA351764F5Brain Non-transgenic Control
SA351765F2Brain Non-transgenic Control
SA351766F3Brain Non-transgenic Control
SA351767F4Brain Non-transgenic Control
SA351768F7Brain Non-transgenic Protein restriction
SA351769F6Brain Non-transgenic Protein restriction
SA351770F8Brain Non-transgenic Protein restriction
SA351771F10Brain Non-transgenic Protein restriction
SA351772M7Brain Non-transgenic Protein restriction
SA351773M6Brain Non-transgenic Protein restriction
SA351774M8Brain Non-transgenic Protein restriction
SA351775M9Brain Non-transgenic Protein restriction
SA351776M10Brain Non-transgenic Protein restriction
SA351777F9Brain Non-transgenic Protein restriction
Showing results 1 to 40 of 40
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