Summary of Study ST003243

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002013. The data can be accessed directly via it's Project DOI: 10.21228/M8DJ7S This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003243
Study TitleLipidomic analysis of serum from WT, liver-specific Gclc KO, liver-specific Nrf2 KO, and liver-specific Gclc-Nrf2 DKO mice.
Study SummaryThe rate-limiting enzyme in glutathione (GSH) synthesis is Gclc. GSH synthesis is suggested to be implicated in lipogenesis. Loss of GSH synthesis is suggested to increase the activity of NRF2. To examine the impact of GSH and NRF2 on lipid abundance in serum, we performed lipidomic analysis of serum from WT, liver-specific Gclc KO, liver-specific Nrf2 KO, and liver-specific Gclc-Nrf2 DKO mice.
Institute
University of Rochester Medical Center
Last NameHarris
First NameIsaac
Address601 Elmwood Ave, Rochester, New York, 14642-0001, USA
Emailisaac_harris@urmc.rochester.edu
Phone8572348624
Submit Date2024-05-29
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2024-06-07
Release Version1
Isaac Harris Isaac Harris
https://dx.doi.org/10.21228/M8DJ7S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Genotype
SA35336024-08-18-2022-POS-Isaac-S01Serum Liver-specific Gclc KO
SA35336127-08-18-2022-POS-Isaac-S04Serum Liver-specific Gclc KO
SA35336225-08-18-2022-POS-Isaac-S02Serum Liver-specific Gclc KO
SA35336326-08-18-2022-POS-Isaac-S03Serum Liver-specific Gclc KO
SA35336432-08-18-2022-POS-Isaac-S09Serum Liver-specific Gclc-Nrf2 DKO
SA35336531-08-18-2022-POS-Isaac-S08Serum Liver-specific Gclc-Nrf2 DKO
SA35336633-08-18-2022-POS-Isaac-S10Serum Liver-specific Gclc-Nrf2 DKO
SA35336730-08-18-2022-POS-Isaac-S07Serum Liver-specific Gclc-Nrf2 DKO
SA35336828-08-18-2022-POS-Isaac-S05Serum Liver-specific Gclc-Nrf2 DKO
SA35336929-08-18-2022-POS-Isaac-S06Serum Liver-specific Gclc-Nrf2 DKO
SA35337041-08-18-2022-POS-Isaac-S17Serum Liver-specific Nrf2 KO
SA35337142-08-18-2022-POS-Isaac-S18Serum Liver-specific Nrf2 KO
SA35337240-08-18-2022-POS-Isaac-S16Serum Liver-specific Nrf2 KO
SA35337339-08-18-2022-POS-Isaac-S15Serum Liver-specific Nrf2 KO
SA35337438-08-18-2022-POS-Isaac-S14Serum WT
SA35337536-08-18-2022-POS-Isaac-S12Serum WT
SA35337635-08-18-2022-POS-Isaac-S11Serum WT
SA35337737-08-18-2022-POS-Isaac-S13Serum WT
Showing results 1 to 18 of 18
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