Summary of Study ST003260

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002023. The data can be accessed directly via it's Project DOI: 10.21228/M8423Z This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003260
Study TitleExploration of RSL3-induced and Chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complex-induced changes in the lipidome of MDA-MB-231 breast cancer cells
Study SummaryChlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes (SCs) exhibit potent anti-cancer properties through incompletely understood molecular mechanisms. Here, we treated human MDA-MB-231 triple-negative breast cancer cells with the glutathione peroxidase (GPX)4 inhibitor RSL3 or chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes (SCs) and analyzed their phospholipid profile by targeted lipidomics. SCs decreased the cellular proportion of polyunsaturated fatty acids (PUFAs) in phospholipids, which barely changed upon short-term treatment with RSL3.
Institute
University of Innsbruck
DepartmentMichael Popp Institute
Last NameKoeberle
First NameAndreas
AddressMitterweg 24, Innsbruck, Tyrol, 6020, Austria
EmailAndreas.Koeberle@uibk.ac.at
Phone+43 512 507 57903
Submit Date2024-06-12
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2024-06-27
Release Version1
Andreas Koeberle Andreas Koeberle
https://dx.doi.org/10.21228/M8423Z
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Treatment time point
SA354103210324_Rescue_Gust_compounds_2h_n2_Ti41_10uM_T58Breast cancer cells 10 µM Comp. 1 2 h
SA354104210324_Rescue_Gust_compounds_2h_n1_Ti41_10uM_T46Breast cancer cells 10 µM Comp. 1 2 h
SA354105210324_Rescue_Gust_compounds_2h_n3_Ti41_10uM_T70Breast cancer cells 10 µM Comp. 1 2 h
SA354106210324_Rescue_Gust_compounds_2h_n1_Ti41_F_10uM_T49Breast cancer cells 10 µM Comp. 2 2 h
SA354107210324_Rescue_Gust_compounds_2h_n2_Ti41_F_10uM_T61Breast cancer cells 10 µM Comp. 2 2 h
SA354108210324_Rescue_Gust_compounds_2h_n3_Ti41_F_10uM_T73Breast cancer cells 10 µM Comp. 2 2 h
SA354109210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_10uM_T76Breast cancer cells 10 µM Comp. 3 2 h
SA354110210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_10uM_T64Breast cancer cells 10 µM Comp. 3 2 h
SA354111210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_10uM_T52Breast cancer cells 10 µM Comp. 3 2 h
SA354115210309_MDA_Timecourse_RSL3_n2_24h_RSL3_10uM_24Breast cancer cells 10 µM RSL3 24 h
SA354116210309_MDA_Timecourse_RSL3_n3_24h_RSL3_10uM_36Breast cancer cells 10 µM RSL3 24 h
SA354117210309_MDA_Timecourse_RSL3_n1_24h_RSL3_10uM_12Breast cancer cells 10 µM RSL3 24 h
SA354112210309_MDA_Timecourse_RSL3_n3_2h_RSL3_10uM_27Breast cancer cells 10 µM RSL3 2 h
SA354113210309_MDA_Timecourse_RSL3_n2_2h_RSL3_10uM_15Breast cancer cells 10 µM RSL3 2 h
SA354114210309_MDA_Timecourse_RSL3_n1_2h_RSL3_10uM_3Breast cancer cells 10 µM RSL3 2 h
SA354118210309_MDA_Timecourse_RSL3_n3_4h_RSL3_10uM_30Breast cancer cells 10 µM RSL3 4 h
SA354119210309_MDA_Timecourse_RSL3_n2_4h_RSL3_10uM_18Breast cancer cells 10 µM RSL3 4 h
SA354120210309_MDA_Timecourse_RSL3_n1_4h_RSL3_10uM_6Breast cancer cells 10 µM RSL3 4 h
SA354121210309_MDA_Timecourse_RSL3_n2_6h_RSL3_10uM_21Breast cancer cells 10 µM RSL3 6 h
SA354122210309_MDA_Timecourse_RSL3_n3_6h_RSL3_10uM_33Breast cancer cells 10 µM RSL3 6 h
SA354123210309_MDA_Timecourse_RSL3_n1_6h_RSL3_10uM_9Breast cancer cells 10 µM RSL3 6 h
SA354076210324_Rescue_Gust_compounds_2h_n1_Ti41_1uM_T44Breast cancer cells 1 µM Comp. 1 2 h
SA354077210324_Rescue_Gust_compounds_2h_n3_Ti41_1uM_T68Breast cancer cells 1 µM Comp. 1 2 h
SA354078210324_Rescue_Gust_compounds_2h_n2_Ti41_1uM_T56Breast cancer cells 1 µM Comp. 1 2 h
SA354079210324_Rescue_Gust_compounds_2h_n2_Ti41_F_1uM_T59Breast cancer cells 1 µM Comp. 2 2 h
SA354080210324_Rescue_Gust_compounds_2h_n3_Ti41_F_1uM_T71Breast cancer cells 1 µM Comp. 2 2 h
SA354081210324_Rescue_Gust_compounds_2h_n1_Ti41_F_1uM_T47Breast cancer cells 1 µM Comp. 2 2 h
SA354082210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_1uM_T62Breast cancer cells 1 µM Comp. 3 2 h
SA354083210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_1uM_T74Breast cancer cells 1 µM Comp. 3 2 h
SA354084210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_1uM_T50Breast cancer cells 1 µM Comp. 3 2 h
SA354085210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_Ferrostatin1_3uM_T67Breast cancer cells 1 µM RSL3 + 3 µM Ferrostatin 2 h
SA354086210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_Ferrostatin1_3uM_T43Breast cancer cells 1 µM RSL3 + 3 µM Ferrostatin 2 h
SA354087210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_Ferrostatin1_3uM_T55Breast cancer cells 1 µM RSL3 + 3 µM Ferrostatin 2 h
SA354094210309_MDA_Timecourse_RSL3_n3_24h_RSL3_1uM_35Breast cancer cells 1 µM RSL3 24 h
SA354095210309_MDA_Timecourse_RSL3_n2_24h_RSL3_1uM_23Breast cancer cells 1 µM RSL3 24 h
SA354096210309_MDA_Timecourse_RSL3_n1_24h_RSL3_1uM_11Breast cancer cells 1 µM RSL3 24 h
SA354088210324_Rescue_Gust_compounds_2h_n2_RSL3_1uM_T54Breast cancer cells 1 µM RSL3 2 h
SA354089210324_Rescue_Gust_compounds_2h_n3_RSL3_1uM_T66Breast cancer cells 1 µM RSL3 2 h
SA354090210309_MDA_Timecourse_RSL3_n3_2h_RSL3_1uM_26Breast cancer cells 1 µM RSL3 2 h
SA354091210309_MDA_Timecourse_RSL3_n1_2h_RSL3_1uM_2Breast cancer cells 1 µM RSL3 2 h
SA354092210324_Rescue_Gust_compounds_2h_n1_RSL3_1uM_T42Breast cancer cells 1 µM RSL3 2 h
SA354093210309_MDA_Timecourse_RSL3_n2_2h_RSL3_1uM_14Breast cancer cells 1 µM RSL3 2 h
SA354097210309_MDA_Timecourse_RSL3_n3_4h_RSL3_1uM_29Breast cancer cells 1 µM RSL3 4 h
SA354098210309_MDA_Timecourse_RSL3_n1_4h_RSL3_1uM_5Breast cancer cells 1 µM RSL3 4 h
SA354099210309_MDA_Timecourse_RSL3_n2_4h_RSL3_1uM_17Breast cancer cells 1 µM RSL3 4 h
SA354100210309_MDA_Timecourse_RSL3_n3_6h_RSL3_1uM_32Breast cancer cells 1 µM RSL3 6 h
SA354101210309_MDA_Timecourse_RSL3_n1_6h_RSL3_1uM_8Breast cancer cells 1 µM RSL3 6 h
SA354102210309_MDA_Timecourse_RSL3_n2_6h_RSL3_1uM_20Breast cancer cells 1 µM RSL3 6 h
SA354124210324_Rescue_Gust_compounds_2h_n1_Ti41_3uM_T45Breast cancer cells 3 µM Comp. 1 2 h
SA354125210324_Rescue_Gust_compounds_2h_n3_Ti41_3uM_T69Breast cancer cells 3 µM Comp. 1 2 h
SA354126210324_Rescue_Gust_compounds_2h_n2_Ti41_3uM_T57Breast cancer cells 3 µM Comp. 1 2 h
SA354127210324_Rescue_Gust_compounds_2h_n1_Ti41_F_3uM_T48Breast cancer cells 3 µM Comp. 2 2 h
SA354128210324_Rescue_Gust_compounds_2h_n3_Ti41_F_3uM_T72Breast cancer cells 3 µM Comp. 2 2 h
SA354129210324_Rescue_Gust_compounds_2h_n2_Ti41_F_3uM_T60Breast cancer cells 3 µM Comp. 2 2 h
SA354130210324_Rescue_Gust_compounds_2h_n1_Ti41_Cl_3uM_T51Breast cancer cells 3 µM Comp. 3 2 h
SA354131210324_Rescue_Gust_compounds_2h_n3_Ti41_Cl_3uM_T75Breast cancer cells 3 µM Comp. 3 2 h
SA354132210324_Rescue_Gust_compounds_2h_n2_Ti41_Cl_3uM_T63Breast cancer cells 3 µM Comp. 3 2 h
SA354139210309_MDA_Timecourse_RSL3_n3_24h_DMSO_34Breast cancer cells DMSO 24 h
SA354140210309_MDA_Timecourse_RSL3_n2_24h_DMSO_22Breast cancer cells DMSO 24 h
SA354141210309_MDA_Timecourse_RSL3_n1_24h_DMSO_10Breast cancer cells DMSO 24 h
SA354133210324_Rescue_Gust_compounds_2h_n3_DMSO_T65Breast cancer cells DMSO 2 h
SA354134210309_MDA_Timecourse_RSL3_n1_2h_DMSO_1Breast cancer cells DMSO 2 h
SA354135210324_Rescue_Gust_compounds_2h_n2_DMSO_T53Breast cancer cells DMSO 2 h
SA354136210309_MDA_Timecourse_RSL3_n3_2h_DMSO_25Breast cancer cells DMSO 2 h
SA354137210309_MDA_Timecourse_RSL3_n2_2h_DMSO_13Breast cancer cells DMSO 2 h
SA354138210324_Rescue_Gust_compounds_2h_n1_DMSO_T41Breast cancer cells DMSO 2 h
SA354142210309_MDA_Timecourse_RSL3_n3_4h_DMSO_28Breast cancer cells DMSO 4 h
SA354143210309_MDA_Timecourse_RSL3_n2_4h_DMSO_16Breast cancer cells DMSO 4 h
SA354144210309_MDA_Timecourse_RSL3_n1_4h_DMSO_4Breast cancer cells DMSO 4 h
SA354145210309_MDA_Timecourse_RSL3_n3_6h_DMSO_31Breast cancer cells DMSO 6 h
SA354146210309_MDA_Timecourse_RSL3_n2_6h_DMSO_19Breast cancer cells DMSO 6 h
SA354147210309_MDA_Timecourse_RSL3_n1_6h_DMSO_7Breast cancer cells DMSO 6 h
Showing results 1 to 72 of 72
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