Summary of Study ST003281

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002033. The data can be accessed directly via it's Project DOI: 10.21228/M8TN7J This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003281
Study TitlePhosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans
Study TypeMetabolomics and lipidomics
Study SummaryThere is a pressing need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin drugs that are fungicidal against other important fungal pathogens are ineffective against Cryptococcus neoformans, the causative agent of life-threatening meningoencephalitis in immunocompromised people. Contributing mechanisms for echinocandin tolerance are emerging with connections to calcineurin signaling, the cell wall, and membrane composition. In this context, we discovered that a defect in phosphate uptake impairs the tolerance of C. neoformans to the echinocandin caspofungin.
Institute
University of British Columbia
DepartmentLife Sciences Institute
Last NameAlcazar Magana
First NameArmando
Address2350 Health Sciences Mall
Emailarmando.alcazarmagana@ubc.ca
Phone5416097172
Submit Date2024-06-12
Num Groups8
Total Subjects28
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-06-28
Release Version1
Armando Alcazar Magana Armando Alcazar Magana
https://dx.doi.org/10.21228/M8TN7J
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Fungi; Subject species: Cryptococcus neoformans (Factor headings shown in green)

mb_sample_id local_sample_id Genotype Treatment Sample source
SA355149H99-0_AH99 0 Cells
SA355150H99-0_BH99 0 Cells
SA355151H99-0_CH99 0 Cells
SA355152H99-250_CH99 250 Cells
SA355153H99-250_BH99 250 Cells
SA355154H99-250_AH99 250 Cells
SA355155H99-iron-20Pi-24h_AH99 H99-iron-20Pi-24h Cells
SA355156H99-iron-20Pi-24h_DH99 H99-iron-20Pi-24h Cells
SA355157H99-iron-20Pi-24h_CH99 H99-iron-20Pi-24h Cells
SA355158H99-iron-20Pi-24h_BH99 H99-iron-20Pi-24h Cells
SA355159H99-iron-20Pi-6h_AH99 H99-iron-20Pi-6h Cells
SA355160H99-iron-20Pi-6h_BH99 H99-iron-20Pi-6h Cells
SA355161H99-iron-20Pi-6h_CH99 H99-iron-20Pi-6h Cells
SA355162H99-iron-20Pi-6h_DH99 H99-iron-20Pi-6h Cells
SA355163H99-iron-24h_AH99 H99-iron-24h Cells
SA355164H99-iron-24h_DH99 H99-iron-24h Cells
SA355165H99-iron-24h_CH99 H99-iron-24h Cells
SA355166H99-iron-24h_BH99 H99-iron-24h Cells
SA355167H99-iron-6h_DH99 H99-iron-6h Cells
SA355168H99-iron-6h_CH99 H99-iron-6h Cells
SA355169H99-iron-6h_BH99 H99-iron-6h Cells
SA355170H99-iron-6h_AH99 H99-iron-6h Cells
SA355171H99-no iron-20Pi-6h_CH99 H99-no iron-20Pi-6h Cells
SA355172H99-no iron-20Pi-6h_DH99 H99-no iron-20Pi-6h Cells
SA355173H99-no iron-20Pi-6h_AH99 H99-no iron-20Pi-6h Cells
SA355174H99-no iron-20Pi-6h_BH99 H99-no iron-20Pi-6h Cells
SA355175H99-no iron-6h_BH99 H99-no iron-6h Cells
SA355176H99-no iron-6h_DH99 H99-no iron-6h Cells
SA355177H99-no iron-6h_AH99 H99-no iron-6h Cells
SA355178H99-no iron-6h_CH99 H99-no iron-6h Cells
SA355179QC3H99 QC Cells
SA355180QC5H99 QC Cells
SA355181QC4H99 QC Cells
SA355182QC1H99 QC Cells
SA355183QC2H99 QC Cells
SA355184Pho-0_APho 0 Cells
SA355185Pho-0_BPho 0 Cells
SA355186Pho-0_CPho 0 Cells
SA355187Pho-250_APho 250 Cells
SA355188Pho-250_BPho 250 Cells
SA355189Pho-250_CPho 250 Cells
SA355190QCL3QC QC Cells
SA355191QCL1QC QC Cells
SA355192QCL2QC QC Cells
Showing results 1 to 44 of 44
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