Summary of Study ST000910
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000631. The data can be accessed directly via it's Project DOI: 10.21228/M83T1G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000910 |
Study Title | Insights into the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) through metabolomic profiling of cerebrospinal fluid (part I) |
Study Summary | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling illness characterized by six months or more of unexplained profound fatigue with post-exertional malaise, sleep abnormalities, cognitive dysfunction and autonomic disturbances. Focusing on the pathogenesis of central nervous system abnormalities in ME/CFS, we pursued metabolomics analysis of cerebrospinal fluid (CSF) in 32 ME/CFS cases, 40 subjects with multiple sclerosis (MS), another fatiguing illness, and 19 healthy subjects with no neurological disease (ND). MS/ND subjects were frequency matched for age and sex to ME/CFS subjects. Three untargeted metabolomic assays for primary metabolites, biogenic amines and complex lipids were performed with gas chromatography time-of-flight (GC-TOF) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) yielding profiles for 525 known metabolites. Mannose was a cardinal biomarker in ME/CFS subjects with reduced levels in ME/CFS compared to both MS and ND subjects. Levels of acetylcarnitine were reduced in ME/CFS vs. MS subjects. The predictive power of metabolomic analysis for diagnosis of ME/CFS vs. ND was higher (cross-validated AUC 0.875; 95% CI: 0.726~0.949) than with cytokine analysis alone (cross-validated AUC 0.865; 95% CI: 0.673~0.952) and improved with integration of both metabolomics and cytokine analyses (cross-validated AUC 0.916; 95% CI: 0.791~0.969). Our findings confirm the biological basis of ME/CFS, and may enable new methods for diagnosis and insight into cognitive and autonomic disturbances in this syndrome. |
Institute | University of California, Davis |
Department | Genome and Biomedical Sciences Facility |
Laboratory | WCMC Metabolomics Core |
Last Name | Fiehn |
First Name | Oliver |
Address | 1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616 |
ofiehn@ucdavis.edu | |
Phone | (530) 754-8258 |
Submit Date | 2017-12-11 |
Raw Data Available | Yes |
Raw Data File Type(s) | cdf |
Analysis Type Detail | GC-MS |
Release Date | 2018-08-27 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Diagnosis | Sex |
---|---|---|---|
SA053406 | 170608aOEsa21_1 | MECFS | FEMALE |
SA053407 | 170607aOEsa01_1 | MECFS | FEMALE |
SA053408 | 170606aOEsa24_2 | MECFS | FEMALE |
SA053409 | 170607aOEsa28_1 | MECFS | FEMALE |
SA053410 | 170607aOEsa38_1 | MECFS | FEMALE |
SA053411 | 170607aOEsa20_1 | MECFS | FEMALE |
SA053412 | 170606aOEsa42_1 | MECFS | FEMALE |
SA053413 | 170606aOEsa21_3 | MECFS | FEMALE |
SA053414 | 170608aOEsa15_1 | MECFS | FEMALE |
SA053415 | 170607aOEsa04_1 | MECFS | FEMALE |
SA053416 | 170608aOEsa06_1 | MECFS | FEMALE |
SA053417 | 170608aOEsa03_1 | MECFS | FEMALE |
SA053418 | 170608aOEsa11_1 | MECFS | FEMALE |
SA053419 | 170607aOEsa31_1 | MECFS | FEMALE |
SA053420 | 170607aOEsa13_1 | MECFS | FEMALE |
SA053421 | 170607aOEsa37_1 | MECFS | FEMALE |
SA053422 | 170607aOEsa46_1 | MECFS | FEMALE |
SA053423 | 170607aOEsa10_1 | MECFS | FEMALE |
SA053424 | 170606aOEsa27_2 | MECFS | FEMALE |
SA053425 | 170606aOEsa38_1 | MECFS | FEMALE |
SA053426 | 170608aOEsa22_1 | MECFS | FEMALE |
SA053427 | 170606aOEsa10_3 | MECFS | MALE |
SA053428 | 170607aOEsa36_1 | MECFS | MALE |
SA053429 | 170606aOEsa07_3 | MECFS | MALE |
SA053430 | 170606aOEsa37_1 | MECFS | MALE |
SA053431 | 170607aOEsa19_1 | MECFS | MALE |
SA053432 | 170606aOEsa47_1 | MECFS | MALE |
SA053433 | 170608aOEsa18_1 | MECFS | MALE |
SA053434 | 170606aOEsa25_2 | MECFS | MALE |
SA053435 | 170606aOEsa22_2 | MECFS | MALE |
SA053436 | 170606aOEsa29_2 | MECFS | MALE |
SA053437 | 170606aOEsa18_3 | MECFS | MALE |
SA053438 | 170607aOEsa24_1 | MS | FEMALE |
SA053439 | 170607aOEsa18_1 | MS | FEMALE |
SA053440 | 170606aOEsa40_1 | MS | FEMALE |
SA053441 | 170607aOEsa22_1 | MS | FEMALE |
SA053442 | 170607aOEsa35_1 | MS | FEMALE |
SA053443 | 170607aOEsa30_1 | MS | FEMALE |
SA053444 | 170607aOEsa26_1 | MS | FEMALE |
SA053445 | 170606aOEsa09_3 | MS | FEMALE |
SA053446 | 170608aOEsa05_1 | MS | FEMALE |
SA053447 | 170606aOEsa17_3 | MS | FEMALE |
SA053448 | 170606aOEsa02_3 | MS | FEMALE |
SA053449 | 170606aOEsa04_3 | MS | FEMALE |
SA053450 | 170607aOEsa27_1 | MS | FEMALE |
SA053451 | 170606aOEsa01_3 | MS | FEMALE |
SA053452 | 170607aOEsa05_1 | MS | FEMALE |
SA053453 | 170606aOEsa20_3 | MS | FEMALE |
SA053454 | 170606aOEsa33_1 | MS | FEMALE |
SA053455 | 170606aOEsa32_1 | MS | FEMALE |
SA053456 | 170608aOEsa12_1 | MS | FEMALE |
SA053457 | 170606aOEsa11_3 | MS | FEMALE |
SA053458 | 170607aOEsa50_1 | MS | FEMALE |
SA053459 | 170606aOEsa36_1 | MS | FEMALE |
SA053460 | 170608aOEsa07_1 | MS | FEMALE |
SA053461 | 170607aOEsa40_1 | MS | FEMALE |
SA053462 | 170607aOEsa14_1 | MS | FEMALE |
SA053463 | 170608aOEsa16_1 | MS | FEMALE |
SA053464 | 170607aOEsa23_1 | MS | FEMALE |
SA053465 | 170607aOEsa48_1 | MS | FEMALE |
SA053466 | 170606aOEsa41_1 | MS | MALE |
SA053467 | 170607aOEsa42_1 | MS | MALE |
SA053468 | 170607aOEsa41_1 | MS | MALE |
SA053469 | 170606aOEsa35_1 | MS | MALE |
SA053470 | 170606aOEsa50_1 | MS | MALE |
SA053471 | 170607aOEsa49_1 | MS | MALE |
SA053472 | 170606aOEsa03_3 | MS | MALE |
SA053473 | 170607aOEsa32_1 | MS | MALE |
SA053474 | 170607aOEsa17_1 | MS | MALE |
SA053475 | 170606aOEsa14_3 | MS | MALE |
SA053476 | 170607aOEsa29_1 | MS | MALE |
SA053477 | 170607aOEsa08_1 | MS | MALE |
SA053478 | 170607aOEsa07_1 | ND | FEMALE |
SA053479 | 170606aOEsa49_1 | ND | FEMALE |
SA053480 | 170608aOEsa01_1 | ND | FEMALE |
SA053481 | 170606aOEsa46_1 | ND | FEMALE |
SA053482 | 170607aOEsa06_1 | ND | FEMALE |
SA053483 | 170608aOEsa02_1 | ND | FEMALE |
SA053484 | 170607aOEsa25_1 | ND | FEMALE |
SA053485 | 170608aOEsa13_1 | ND | FEMALE |
SA053486 | 170608aOEsa09_1 | ND | FEMALE |
SA053487 | 170608aOEsa19_1 | ND | FEMALE |
SA053488 | 170608aOEsa10_1 | ND | FEMALE |
SA053489 | 170607aOEsa43_1 | ND | FEMALE |
SA053490 | 170606aOEsa34_1 | ND | FEMALE |
SA053491 | 170606aOEsa15_3 | ND | MALE |
SA053492 | 170606aOEsa12_3 | ND | MALE |
SA053493 | 170607aOEsa16_1 | ND | MALE |
SA053494 | 170607aOEsa39_1 | ND | MALE |
SA053495 | 170607aOEsa09_1 | ND | MALE |
SA053496 | 170606aOEsa48_1 | ND | MALE |
Showing results 1 to 91 of 91 |