Summary of Study ST001002

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000678. The data can be accessed directly via it's Project DOI: 10.21228/M81Q26 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study ID	ST001002
Study Title	A pilot study of urine metabolomics in two female and one male subject towards an outpatient estimate of circadian phase using urine storage as a factor (part II)
Study Summary	Serial urine samples were collected at each void (approximately every 3 hours) from subjects during a 6-day inpatient protocol. The total volume of each sample was measured, and then 5 mL was aliquoted into a 7 mL tube and elivered on ice to the processing lab, where the samples were then stored at either -20 degrees or -80 degrees (see details below). At the end of the study, samples were transported (~2 blocks) from the processing lab to our -20 or -80 freezer for storage. The samples being sent represent samples from two female subjects (3634A and 3635A) and one male subject (3624A). These subjects all spent 6 days in the lab: 3 baseline days where the subjects slept for 8 hours at night (at habitual times as determined during the screening period) and 16 hours of ambulatory wake in ambient light, followed by 50 hours of continuous wakefulness in which the subject was kept in a semi-recumbent position in bed under dim light and fed hourly isocaloric snacks (called a constant routine). We are requesting untargeted profiling of samples from these subjects (plus 6-sulphatoxymelatonin profile) to determine how the concentrations of different metabolites vary across the 24-hour period, and specifically to compare this circadian variation in each metabolite during a 48-hour ambulatory period versus a 48-hour constant routine period.
Institute	Mayo Clinic
Last Name	Hilaire
First Name	Melissa
Address	221 Longwood Avenue, Suite BL438 Boston, Massachusetts 02115
Email	msthilaire@rics.bwh.harvard.edu
Phone	617-732-4013
Submit Date	2018-07-10
Analysis Type Detail	LC-MS
Release Date	2022-12-15
Release Version	1

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id	local_sample_id	hour
SA062580	pC18-16aug17-087	10 \| day:day1 \| Group:Baseline -20 storage
SA062581	nC18-17aug17-087	10 \| day:day1 \| Group:Baseline -20 storage
SA062582	nhilic-12aug17-087	10 \| day:day1 \| Group:Baseline -20 storage
SA062583	philic-11aug17-087	10 \| day:day1 \| Group:Baseline -20 storage
SA062584	nhilic-05aug17-014	10 \| day:day3 \| Group:CR -20 storage
SA062585	pC18-04aug17-014	10 \| day:day3 \| Group:CR -20 storage
SA062586	nC18-05aug17-014	10 \| day:day3 \| Group:CR -20 storage
SA062587	philic-04aug17-014	10 \| day:day3 \| Group:CR -20 storage
SA062588	nC18-05aug17-020	10 \| day:day4 \| Group:CR -20 storage
SA062589	nhilic-05aug17-020	10 \| day:day4 \| Group:CR -20 storage
SA062590	philic-04aug17-020	10 \| day:day4 \| Group:CR -20 storage
SA062591	philic-14aug17-119	10 \| day:day4 \| Group:CR -20 storage
SA062592	pC18-04aug17-020	10 \| day:day4 \| Group:CR -20 storage
SA062593	nhilic-15aug17-119	10 \| day:day4 \| Group:CR -20 storage
SA062594	nC18-19aug17-119	10 \| day:day4 \| Group:CR -20 storage
SA062595	pC18-18aug17-119	10 \| day:day4 \| Group:CR -20 storage
SA062596	pC18-04aug17-001	11 \| day:day1 \| Group:Baseline -20 storage
SA062597	nC18-05aug17-001	11 \| day:day1 \| Group:Baseline -20 storage
SA062598	nhilic-12aug17-088	11 \| day:day1 \| Group:Baseline -20 storage
SA062599	nC18-17aug17-088	11 \| day:day1 \| Group:Baseline -20 storage
SA062600	philic-11aug17-088	11 \| day:day1 \| Group:Baseline -20 storage
SA062601	pC18-16aug17-088	11 \| day:day1 \| Group:Baseline -20 storage
SA062602	philic-04aug17-001	11 \| day:day1 \| Group:Baseline -20 storage
SA062603	nhilic-05aug17-001	11 \| day:day1 \| Group:Baseline -20 storage
SA062604	nC18-17aug17-097	11 \| day:day2 \| Group:Baseline -20 storage
SA062605	nhilic-12aug17-097	11 \| day:day2 \| Group:Baseline -20 storage
SA062606	pC18-16aug17-097	11 \| day:day2 \| Group:Baseline -20 storage
SA062607	nC18-11aug17-034	11 \| day:day2 \| Group:Baseline -20 storage
SA062608	philic-11aug17-097	11 \| day:day2 \| Group:Baseline -20 storage
SA062609	philic-07aug17-034	11 \| day:day2 \| Group:Baseline -20 storage
SA062610	pC18-09aug17-034	11 \| day:day2 \| Group:Baseline -20 storage
SA062611	nC18-05aug17-007	11 \| day:day2 \| Group:Baseline -20 storage
SA062612	nhilic-05aug17-007	11 \| day:day2 \| Group:Baseline -20 storage
SA062613	pC18-04aug17-007	11 \| day:day2 \| Group:Baseline -20 storage
SA062614	nhilic-08aug17-034	11 \| day:day2 \| Group:Baseline -20 storage
SA062615	philic-04aug17-007	11 \| day:day2 \| Group:Baseline -20 storage
SA062616	nC18-15aug17-063	11 \| day:day2 \| Group:Baseline -80 storage
SA062617	philic-09aug17-063	11 \| day:day2 \| Group:Baseline -80 storage
SA062618	pC18-14aug17-063	11 \| day:day2 \| Group:Baseline -80 storage
SA062619	nhilic-10aug17-063	11 \| day:day2 \| Group:Baseline -80 storage
SA062620	nC18-19aug17-107	11 \| day:day3 \| Group:CR -20 storage
SA062621	philic-14aug17-107	11 \| day:day3 \| Group:CR -20 storage
SA062622	nhilic-15aug17-107	11 \| day:day3 \| Group:CR -20 storage
SA062623	pC18-18aug17-107	11 \| day:day3 \| Group:CR -20 storage
SA062624	nC18-19aug17-120	11 \| day:day4 \| Group:CR -20 storage
SA062625	nhilic-15aug17-120	11 \| day:day4 \| Group:CR -20 storage
SA062626	philic-14aug17-120	11 \| day:day4 \| Group:CR -20 storage
SA062627	pC18-18aug17-120	11 \| day:day4 \| Group:CR -20 storage
SA062628	nC18-11aug17-027	12 \| day:day1 \| Group:Baseline -20 storage
SA062629	pC18-09aug17-027	12 \| day:day1 \| Group:Baseline -20 storage
SA062630	philic-07aug17-027	12 \| day:day1 \| Group:Baseline -20 storage
SA062631	nhilic-08aug17-027	12 \| day:day1 \| Group:Baseline -20 storage
SA062632	pC18-14aug17-056	12 \| day:day1 \| Group:Baseline -80 storage
SA062633	philic-09aug17-056	12 \| day:day1 \| Group:Baseline -80 storage
SA062634	nC18-15aug17-056	12 \| day:day1 \| Group:Baseline -80 storage
SA062635	nhilic-10aug17-056	12 \| day:day1 \| Group:Baseline -80 storage
SA062636	nC18-11aug17-035	12 \| day:day2 \| Group:Baseline -20 storage
SA062637	philic-07aug17-035	12 \| day:day2 \| Group:Baseline -20 storage
SA062638	pC18-09aug17-035	12 \| day:day2 \| Group:Baseline -20 storage
SA062639	nhilic-08aug17-035	12 \| day:day2 \| Group:Baseline -20 storage
SA062640	philic-09aug17-064	12 \| day:day2 \| Group:Baseline -80 storage
SA062641	nhilic-10aug17-064	12 \| day:day2 \| Group:Baseline -80 storage
SA062642	pC18-14aug17-064	12 \| day:day2 \| Group:Baseline -80 storage
SA062643	nC18-15aug17-064	12 \| day:day2 \| Group:Baseline -80 storage
SA062644	nhilic-08aug17-044	12 \| day:day3 \| Group:CR -20 storage
SA062645	pC18-09aug17-044	12 \| day:day3 \| Group:CR -20 storage
SA062646	nC18-11aug17-044	12 \| day:day3 \| Group:CR -20 storage
SA062647	philic-07aug17-044	12 \| day:day3 \| Group:CR -20 storage
SA062648	pC18-14aug17-073	12 \| day:day3 \| Group:CR -80 storage
SA062649	nhilic-10aug17-073	12 \| day:day3 \| Group:CR -80 storage
SA062650	nC18-15aug17-073	12 \| day:day3 \| Group:CR -80 storage
SA062651	philic-09aug17-073	12 \| day:day3 \| Group:CR -80 storage
SA062652	nhilic-12aug17-089	13 \| day:day1 \| Group:Baseline -20 storage
SA062653	pC18-16aug17-089	13 \| day:day1 \| Group:Baseline -20 storage
SA062654	philic-11aug17-089	13 \| day:day1 \| Group:Baseline -20 storage
SA062655	pC18-04aug17-002	13 \| day:day1 \| Group:Baseline -20 storage
SA062656	nhilic-05aug17-002	13 \| day:day1 \| Group:Baseline -20 storage
SA062657	nC18-05aug17-002	13 \| day:day1 \| Group:Baseline -20 storage
SA062658	philic-04aug17-002	13 \| day:day1 \| Group:Baseline -20 storage
SA062659	nC18-17aug17-089	13 \| day:day1 \| Group:Baseline -20 storage
SA062660	philic-07aug17-036	13 \| day:day2 \| Group:Baseline -20 storage
SA062661	nhilic-08aug17-036	13 \| day:day2 \| Group:Baseline -20 storage
SA062662	nhilic-05aug17-008	13 \| day:day2 \| Group:Baseline -20 storage
SA062663	pC18-04aug17-008	13 \| day:day2 \| Group:Baseline -20 storage
SA062664	philic-04aug17-008	13 \| day:day2 \| Group:Baseline -20 storage
SA062665	nC18-05aug17-008	13 \| day:day2 \| Group:Baseline -20 storage
SA062666	nC18-11aug17-036	13 \| day:day2 \| Group:Baseline -20 storage
SA062667	pC18-09aug17-036	13 \| day:day2 \| Group:Baseline -20 storage
SA062668	philic-09aug17-065	13 \| day:day2 \| Group:Baseline -80 storage
SA062669	pC18-14aug17-065	13 \| day:day2 \| Group:Baseline -80 storage
SA062670	nC18-15aug17-065	13 \| day:day2 \| Group:Baseline -80 storage
SA062671	nhilic-10aug17-065	13 \| day:day2 \| Group:Baseline -80 storage
SA062672	nC18-05aug17-015	13 \| day:day3 \| Group:CR -20 storage
SA062673	philic-04aug17-015	13 \| day:day3 \| Group:CR -20 storage
SA062674	nhilic-05aug17-015	13 \| day:day3 \| Group:CR -20 storage
SA062675	pC18-04aug17-015	13 \| day:day3 \| Group:CR -20 storage
SA062676	pC18-09aug17-050	13 \| day:day4 \| Group:CR -20 storage
SA062677	nhilic-08aug17-050	13 \| day:day4 \| Group:CR -20 storage
SA062678	philic-07aug17-050	13 \| day:day4 \| Group:CR -20 storage
SA062679	nC18-05aug17-021	13 \| day:day4 \| Group:CR -20 storage