Summary of Study ST002186
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001393. The data can be accessed directly via it's Project DOI: 10.21228/M8NT4K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002186 |
| Study Title | An early-life microbiota metabolite protects against obesity via intestinal PPAR-gamma |
| Study Type | untargeted metabolomics analysis |
| Study Summary | The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse model in which young mice are simultaneously exposed to antibiotics and a high-fat diet, we show that Lactobacillus species, predominant members of the small intestine microbiota, regulate intestinal epithelial cells (IECs) to limit diet-induced obesity during early-life. A Lactobacillus-derived metabolite, phenyllactic acid (PLA), protected against metabolic dysfunction caused by early-life exposure to antibiotics and a high-fat diet by increasing the abundance of peroxisome proliferator activated receptor gamma (PPAR-gamma) in the small intestine IECs. Therefore, PLA is a microbiota-derived metabolite that activates protective pathways in the small intestine epithelium to regulate fat absorption and prevent obesity during early life. |
| Institute | Vanderbilt University |
| Department | Chemistry |
| Laboratory | Center for Innovative Technology |
| Last Name | Codreanu |
| First Name | Simona Gabriella |
| Address | 1234 Stevenson Center Lane |
| SIMONA.CODREANU@VANDERBILT.EDU | |
| Phone | 6158758422 |
| Submit Date | 2022-06-03 |
| Num Groups | 4 |
| Total Subjects | 20 |
| Num Males | 20 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-06-06 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Other organism; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Treatment |
|---|---|---|
| SA210048 | HFP_381_S16 | HF diet + LDP (HFP) |
| SA210049 | HFP_382_S17 | HF diet + LDP (HFP) |
| SA210050 | HFP_383_S18 | HF diet + LDP (HFP) |
| SA210051 | HFP_384_S19 | HF diet + LDP (HFP) |
| SA210052 | HFP_386_S20 | HF diet + LDP (HFP) |
| SA210053 | HF_374_S13 | High fat (HF) diet |
| SA210054 | HF_375_S14 | High fat (HF) diet |
| SA210055 | HF_376_S15 | High fat (HF) diet |
| SA210056 | HF_372_S12 | High fat (HF) diet |
| SA210057 | HF_371_S11 | High fat (HF) diet |
| SA210058 | LF_356_S05 | LF diet |
| SA210059 | LF_354_S04 | LF diet |
| SA210060 | LF_353_S03 | LF diet |
| SA210061 | LF_352_S02 | LF diet |
| SA210062 | LFP_361_S06 | LF diet + low dose penicillin (LFP) |
| SA210063 | LFP_362_S07 | LF diet + low dose penicillin (LFP) |
| SA210064 | LFP_365_S10 | LF diet + low dose penicillin (LFP) |
| SA210065 | LFP_364_S09 | LF diet + low dose penicillin (LFP) |
| SA210066 | LFP_363_S08 | LF diet + low dose penicillin (LFP) |
| SA210067 | LF_351_S01 | Low Fat (LF) diet |
| Showing results 1 to 20 of 20 |
