Summary of Study ST002520

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001622. The data can be accessed directly via it's Project DOI: 10.21228/M81T5C This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002520
Study TitleThe investigation of the role of dietary inulin in Non-alcoholic Steatohepatitis (NASH) progression with portal vein serum metabolites
Study Typenon-targeted LC-Mass analysis
Study SummaryTo investigate the role of dietary fiber in non-alcoholic steatohepatitis (NASH) progression, male C57 mice was randomly assigned into four groups that received normal chow diet (NCD), choline deficient high fat diet (CDHFD), CDHFD + 10% inulin (CDHFD-I), CDHFD + 10% Cellulose (CDHFD-C). Mice portal vein serum was collected.Results shown that the fecal metabolites from Inulin treatment group signficantly distinguished from that from CDHFD only group, while only negligible alterations was induced by cellulose treatment, indicating that inulin not cellulose could be well fermented by gut microbiota. By overlaping with fecal metabolites, the inulin derived pentadecaonic acid was consistently enriched in portal vein serum, which was reported as a beneficial metabolite.The results indicate that inulin suppresses NASH may through direct modulating gut metabolites.
Institute
The Chinese University of Hong Kong
Last NameWei
First NameWenchao
AddressPrince of Wales Hospital
Email1155118538@link.cuhk.edu.hk
Phone56001913
Submit Date2023-03-17
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2023-05-19
Release Version1
Wenchao Wei Wenchao Wei
https://dx.doi.org/10.21228/M81T5C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA253988X3773posCDHFD
SA253989X3772posCDHFD
SA253990X3774posCDHFD
SA253991X3777posCDHFD
SA253992X3780posCDHFD
SA253993X3771negCDHFD
SA253994X3775posCDHFD
SA253995X3771posCDHFD
SA253996X3777negCDHFD
SA253997X3774negCDHFD
SA253998X3773negCDHFD
SA253999X3772negCDHFD
SA254000X3780negCDHFD
SA254001X3775negCDHFD
SA254002X3792posCDHFD-C
SA254003X3794posCDHFD-C
SA254004X3791posCDHFD-C
SA254005X3791negCDHFD-C
SA254006X3792negCDHFD-C
SA254007X3796posCDHFD-C
SA254008X3793posCDHFD-C
SA254009X3794negCDHFD-C
SA254010X3800posCDHFD-C
SA254011X3796negCDHFD-C
SA254012X3800negCDHFD-C
SA254013X3793negCDHFD-C
SA254014X3785posCDHFD-I
SA254015X3784posCDHFD-I
SA254016X3786posCDHFD-I
SA254017X3788posCDHFD-I
SA254018X3786negCDHFD-I
SA254019X3787negCDHFD-I
SA254020X3790posCDHFD-I
SA254021X3787posCDHFD-I
SA254022X3781posCDHFD-I
SA254023X3788negCDHFD-I
SA254024X3784negCDHFD-I
SA254025X3781negCDHFD-I
SA254026X3790negCDHFD-I
SA254027X3785negCDHFD-I
SA254028X3717posNCD
SA254029X3718negNCD
SA254030X3718posNCD
SA254031X3717negNCD
SA254032X3729posNCD
SA254033X3727posNCD
SA254034X3725posNCD
SA254035X3725negNCD
SA254036X3727negNCD
SA254037X3729negNCD
SA254038QC04posQC
SA254039QC03posQC
SA254040QC05posQC
SA254041QC05negQC
SA254042QC02posQC
SA254043QC04negQC
SA254044QC01negQC
SA254045QC02negQC
SA254046QC03negQC
SA254047QC01posQC
Showing results 1 to 60 of 60
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