Summary of Study ST003067

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001913. The data can be accessed directly via it's Project DOI: 10.21228/M8FH9H This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003067
Study TitleAttenuation of Helicobacter pylori VacA toxin-induced cell death by modulation of intracellular taurine metabolism - Study #1
Study Typeuntargeted metabolomics analysis
Study SummaryVacA alters the metabolite content of AGS cells. To detect potential VacA-induced metabolic alterations in host cells, we treated AGS cells with acid-activated VacA (20 μg/ml) or acidified buffer control for 2, 8, or 12 hours and performed untargeted global metabolic on the harvested cell pellets. AGS cells treated with VacA under these conditions do not undergo VacA-induced cell death. Analysis of the results showed that AGS cells treated with VacA had a significantly different metabolic profile than cells treated with an acidified-buffer control, both for RPLC and HILIC analyses.
Institute
Vanderbilt University
DepartmentChemistry
LaboratoryCenter for Innovative Technology
Last NameCODREANU
First NameSIMONA
Address1234 STEVENSON CENTER LANE
EmailSIMONA.CODREANU@VANDERBILT.EDU
Phone6158758422
Submit Date2024-02-02
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2024-06-12
Release Version1
SIMONA CODREANU SIMONA CODREANU
https://dx.doi.org/10.21228/M8FH9H
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Treatment Treatment
SA332028rT12_1Control 12h
SA332029rT12_2Control 12h
SA332030rT12_3Control 12h
SA332031hT12_1Control 12h
SA332032hT12_2Control 12h
SA332033hT12_4Control 12h
SA332034hT12_3Control 12h
SA332035rT12_4Control 12h
SA332036hT2_4Control 2h
SA332037hT2_3Control 2h
SA332038hT2_2Control 2h
SA332039rT2_1Control 2h
SA332040hT2_1Control 2h
SA332041rT2_3Control 2h
SA332042rT2_2Control 2h
SA332043rT2_4Control 2h
SA332044rT8_1Control 8h
SA332045hT8_2Control 8h
SA332046hT8_3Control 8h
SA332047hT8_4Control 8h
SA332048hT8_1Control 8h
SA332049rT8_2Control 8h
SA332050rT8_3Control 8h
SA332051rT8_4Control 8h
SA332052hT12_7VacA 12h
SA332053hT12_8VacA 12h
SA332054rT12_8VacA 12h
SA332055rT12_5VacA 12h
SA332056hT12_6VacA 12h
SA332057hT12_5VacA 12h
SA332058rT12_7VacA 12h
SA332059rT12_6VacA 12h
SA332060rT2_6VacA 2h
SA332061rT2_5VacA 2h
SA332062hT2_8VacA 2h
SA332063hT2_5VacA 2h
SA332064rT2_7VacA 2h
SA332065rT2_8VacA 2h
SA332066hT2_7VacA 2h
SA332067hT2_6VacA 2h
SA332068rT8_5VacA 8h
SA332069rT8_6VacA 8h
SA332070rT8_8VacA 8h
SA332071hT8_6VacA 8h
SA332072hT8_7VacA 8h
SA332073hT8_5VacA 8h
SA332074hT8_8VacA 8h
SA332075rT8_7VacA 8h
Showing results 1 to 48 of 48
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