Summary of Study ST003070

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001913. The data can be accessed directly via it's Project DOI: 10.21228/M8FH9H This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003070
Study TitleAttenuation of Helicobacter pylori VacA toxin-induced cell death by modulation of intracellular taurine metabolism - Study #3
Study Typeuntargeted metabolomics analysis
Study SummaryEffects of VacA on metabolic profiles of AZ-521 cells. Previous studies showed that VacA causes vacuolation of both AGS and AZ-521 gastro-duodenal epithelial cell types. Notably, VacA treatment of AZ-521 cells with purified VacA for 24 hours results in cell death, whereas AGS cells are relatively resistant to VacA-induced cell death at this time point. To investigate potential similarities and differences in VacA-induced metabolic alterations in AGS and AZ-521 cells, we treated both AZ-521 cells and AGS cells with an acidified buffer control or WT s1m1 VacA (20 ug/mL) for 3 or 5 hours. VacA did not impact cell viability of either cell type at these timepoints.
Institute
Vanderbilt University
DepartmentChemistry
LaboratoryCenter for Innovative Technology
Last NameCODREANU
First NameSIMONA
Address1234 STEVENSON CENTER LANE
EmailSIMONA.CODREANU@VANDERBILT.EDU
Phone6158758422
Submit Date2024-02-07
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2024-06-12
Release Version1
SIMONA CODREANU SIMONA CODREANU
https://dx.doi.org/10.21228/M8FH9H
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Treatment genotype
SA332168A3_1Buffer_3h AGS cells
SA332169A3_4Buffer_3h AGS cells
SA332170A3_5Buffer_3h AGS cells
SA332171A3_3Buffer_3h AGS cells
SA332172A3_2Buffer_3h AGS cells
SA332173Z3_2Buffer_3h AZ521 cells
SA332174Z3_3Buffer_3h AZ521 cells
SA332175Z3_5Buffer_3h AZ521 cells
SA332176Z3_4Buffer_3h AZ521 cells
SA332177Z3_1Buffer_3h AZ521 cells
SA332178A6_1Buffer_5h AGS cells
SA332179A6_2Buffer_5h AGS cells
SA332180A6_5Buffer_5h AGS cells
SA332181A6_3Buffer_5h AGS cells
SA332182A6_4Buffer_5h AGS cells
SA332183Z6_1Buffer_5h AZ521 cells
SA332184Z6_3Buffer_5h AZ521 cells
SA332185Z6_2Buffer_5h AZ521 cells
SA332186Z6_5Buffer_5h AZ521 cells
SA332187Z6_4Buffer_5h AZ521 cells
SA332188A3_7Toxin_3h AGS cells
SA332189A3_6Toxin_3h AGS cells
SA332190A3_8Toxin_3h AGS cells
SA332191A3_10Toxin_3h AGS cells
SA332192A3_9Toxin_3h AGS cells
SA332193Z3_10Toxin_3h AZ521 cells
SA332194Z3_9Toxin_3h AZ521 cells
SA332195Z3_6Toxin_3h AZ521 cells
SA332196Z3_8Toxin_3h AZ521 cells
SA332197Z3_7Toxin_3h AZ521 cells
SA332198A6_8Toxin_5h AGS cells
SA332199A6_6Toxin_5h AGS cells
SA332200A6_7Toxin_5h AGS cells
SA332201A6_9Toxin_5h AGS cells
SA332202A6_10Toxin_5h AGS cells
SA332203Z6_9Toxin_5h AZ521 cells
SA332204Z6_10Toxin_5h AZ521 cells
SA332205Z6_8Toxin_5h AZ521 cells
SA332206Z6_6Toxin_5h AZ521 cells
SA332207Z6_7Toxin_5h AZ521 cells
Showing results 1 to 40 of 40
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