Summary of Study ST000107
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000046. The data can be accessed directly via it's Project DOI: 10.21228/M84S36 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000107 |
Study Title | Metabolomic and lipidomic profiles in response to exogenous insulin and GLP-1 infusions during prolonged fasting |
Study Type | Timecourse |
Study Summary | Seventeen northern elephant seal pups constituting four different cohorts at Año Nuevo State Reserve were studied at two post-weaning periods: early (1-2 wk post weaning; n=5) and late (6-7 weeks post weaning; n=12). Study #1: Prior to each infusion protocol, plasma U/kg). Following the infusion, blood samples were collected at 10,To determine the effects of prolonged fasting on peripheral insulin activity and function, samples were collected. Ten fasting seal pups (n=5 early, n=5 late) were infused (i.v.) with a mass-specific dose of insulin (0.065 U/kg). Following the infusion, blood samples were collected at 10, 30, 60, 90, and 120 minutes. Study #2: Seven, late-fasted seal pups were administered either a low (LDG; 10 pmol/kg; n=3) or high (HDG; 100 pmol/kg; n=4) dose of GLP-1 immediately following a glucose bolus (0.5 g/kg) (i.v.) infused within 2 mins. the infusions, blood samples were collected at 10, 30, 60, 90, 120, and 150 minutes. |
Institute | University of California, Davis |
Department | Nutrition |
Laboratory | Newman |
Last Name | Newman |
First Name | John |
Address | 430 W. Health Sciences Dr., Davis, CA 95616 |
john.newman@ars.usda.gov | |
Phone | +1-530-752-1009 |
Submit Date | 2014-07-10 |
Num Groups | 4 |
Total Subjects | 5 |
Raw Data Available | Yes |
Raw Data File Type(s) | wiff |
Uploaded File Size | 751 M |
Analysis Type Detail | GC-MS/LC-MS |
Release Date | 2015-02-03 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN000177 | AN000178 |
---|---|---|
Analysis type | MS | MS |
Chromatography type | GC | GC |
Chromatography system | ||
Column | ||
MS Type | ESI | EI |
MS instrument type | Triple quadrupole | Single quadrupole |
MS instrument name | ABI Sciex API 4000 QTrap | Agilent 5973N |
Ion Mode | POSITIVE | POSITIVE |
Units | nM | nM |
MS:
MS ID: | MS000140 |
Analysis ID: | AN000177 |
Instrument Name: | ABI Sciex API 4000 QTrap |
Instrument Type: | Triple quadrupole |
MS Type: | ESI |
MS Comments: | LC/MS |
Ion Mode: | POSITIVE |
Ion Source Temperature: | See protocol/methods file |
Ion Spray Voltage: | See protocol/methods file |
MS ID: | MS000141 |
Analysis ID: | AN000178 |
Instrument Name: | Agilent 5973N |
Instrument Type: | Single quadrupole |
MS Type: | EI |
MS Comments: | LC/MS |
Ion Mode: | POSITIVE |
Ion Source Temperature: | See protocol/methods file |
Ion Spray Voltage: | See protocol/methods file |