Summary of Study ST002118
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001343. The data can be accessed directly via it's Project DOI: 10.21228/M8439K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002118 |
Study Title | Exposures to Metals in Pregnant Women and the Impact on Fetal Development and Birth Outcomes in Suriname |
Study Type | C18 Reversed-Phase Broad Spectrum Metabolomics |
Study Summary | The Caribbean Consortium for Environmental and Occupational Health, a NIH-funded integrated research and research training program, started in 2015. The research component is a population-based prospective longitudinal environmental epidemiologic cohort study addressing the potential adverse impact of chemical and non-chemical environmental exposures in mother/child dyads in Suriname. The study determines associations between exposures to neurotoxicants (metals and pesticides) and essential elements and non-chemical stressors in pregnant women and the impact on birth and neurodevelopmental outcomes. The study population consists of culturally diverse pregnant women (n=1143; ages: 16-49 years) and their babies/children (n=1069). Data collection takes place twice prenatally, at birth, 12, 36, and 48 months. Through HHEAR, targeted and untargeted (metabolomics) analyses will characterize exposure to metals in a sub-cohort of pregnant women for whom exposure data are not yet available. This expanded exposure analysis will enable a more comprehensive cumulative risk assessment of adverse birth and neurodevelopmental outcomes in the overall cohort. |
Institute | University of Pittsburgh |
Department | Department of Environmental and Occupational Health |
Last Name | Lichtveld |
First Name | Maureen |
Address | 130 DeSoto Street, University of Pittsburgh, Pittsburgh, PA 15261 |
mlichtve@pitt.edu | |
Phone | 412-624-6818 |
Submit Date | 2022-03-22 |
Total Subjects | 668 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Chear Study | Yes |
Analysis Type Detail | LC-MS |
Release Date | 2023-03-22 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN003466 |
---|---|
Analysis type | MS |
Chromatography type | Reversed phase |
Chromatography system | Thermo Vanquish |
Column | Waters ACQUITY UPLC HSS T3 (100 x 2.1mm,3um) |
MS Type | ESI |
MS instrument type | Orbitrap |
MS instrument name | Thermo Q Exactive HF-X Orbitrap |
Ion Mode | POSITIVE |
Units | Area |
MS:
MS ID: | MS003227 |
Analysis ID: | AN003466 |
Instrument Name: | Thermo Q Exactive HF-X Orbitrap |
Instrument Type: | Orbitrap |
MS Type: | ESI |
MS Comments: | Instrument: Thermo Q Exactive HFx Software: Xcalibur 4.1.31.9 for data acquisition; Progenesis QI 2.1 for data preprocessing |
Ion Mode: | POSITIVE |
Capillary Temperature: | 320 °C |
Collision Energy: | 20-45, ramp |
Collision Gas: | N2 |
Dry Gas Flow: | 55 |
Dry Gas Temp: | 400°C |
Fragmentation Method: | CID |
Mass Accuracy: | 5 ppm |
Spray Voltage: | 3.5 KV |
Dataformat: | Profile |
Desolvation Gas Flow: | 55 |