Summary of Study ST003091
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001920. The data can be accessed directly via it's Project DOI: 10.21228/M8JB09 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST003091 |
Study Title | T cell Immune Escape in Blast Crisis Transformation of Chronic Myeloid Leukemia |
Study Type | Untargeted metabolomics |
Study Summary | We report that leukemia secreted cytokines reduce miR-142 levels in T cells, causing T cell loss and exhaustion and therefore promoting CML BC transformation. Our homemade synthetic miR-142 increased T cell antileukemic activity and significantly prolonged the survival of CML BC murine and PDX models. |
Institute | Translational Genomics Research Institute |
Department | Integrated Mass Spectrometry Shared Resources |
Last Name | Pirrotte |
First Name | Patrick |
Address | 445 N 5th St Phoenix, AZ 85004 |
ppirrotte@tgen.org | |
Phone | 6023438400 |
Submit Date | 2024-01-26 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2024-03-01 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN005056 | AN005057 | AN005058 | AN005059 |
---|---|---|---|---|
Analysis type | MS | MS | MS | MS |
Chromatography type | Reversed phase | Reversed phase | HILIC | HILIC |
Chromatography system | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 |
Column | Thermo Hypersil Gold C18 (150x 2.1mm, 3uM) | Thermo Hypersil Gold C18 (150x 2.1mm, 3uM) | Waters ACQUITY UPLC BEH Amide (150 x 2.1mm,1.7um) | Waters ACQUITY UPLC BEH Amide (150 x 2.1mm,1.7um) |
MS Type | ESI | ESI | ESI | ESI |
MS instrument type | Orbitrap | Orbitrap | Orbitrap | Orbitrap |
MS instrument name | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer |
Ion Mode | POSITIVE | NEGATIVE | POSITIVE | NEGATIVE |
Units | Peak area | Peak area | Peak area | Peak area |
MS:
MS ID: | MS004794 |
Analysis ID: | AN005056 |
Instrument Name: | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer |
Instrument Type: | Orbitrap |
MS Type: | ESI |
MS Comments: | Xcalibur software for Data dependent acquisition Compound discoverer 3.2 for data processing Skyline for data evaluation |
Ion Mode: | POSITIVE |
MS ID: | MS004795 |
Analysis ID: | AN005057 |
Instrument Name: | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer |
Instrument Type: | Orbitrap |
MS Type: | ESI |
MS Comments: | Xcalibur software for Data dependent acquisition Compound discoverer 3.2 for data processing Skyline for data evaluation |
Ion Mode: | NEGATIVE |
MS ID: | MS004796 |
Analysis ID: | AN005058 |
Instrument Name: | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer |
Instrument Type: | Orbitrap |
MS Type: | ESI |
MS Comments: | Xcalibur software for Data dependent acquisition Compound discoverer 3.2 for data processing Skyline for data evaluation |
Ion Mode: | POSITIVE |
MS ID: | MS004797 |
Analysis ID: | AN005059 |
Instrument Name: | Thermo Orbitrap Fusion Lumos Tribrid Mass Spectrometer |
Instrument Type: | Orbitrap |
MS Type: | ESI |
MS Comments: | Xcalibur software for Data dependent acquisition Compound discoverer 3.2 for data processing Skyline for data evaluation |
Ion Mode: | NEGATIVE |