Return to study ST001354 main page
MB Sample ID: SA098271
Local Sample ID: | 80004_T48 |
Subject ID: | SU001428 |
Subject Type: | Human |
Subject Species: | Homo sapiens |
Taxonomy ID: | 9606 |
Age Or Age Range: | 18-90+ |
Gender: | Male and female |
Human Race: | White, Black, Asian, Other |
Human Inclusion Criteria: | Criteria for inclusion were as follows: (1) patients 18 years or older with confirmed or presumed infection; (2) the presence of 2 or more systemic inflammatory response criteria; (3) enrollment within 24 hours of recognition of septic shock with initiation of a standardized sepsis treatment pathway; (4) the use of high-dose vasopressors (norepinephrine bitartrate >0.05 μg/kg/min, dopamine hydrochloride >10 μg/kg/min, phenylephrine hydrochloride >0.4 μg/kg/min, epinephrine >0.05 μg/kg/min, or any vasopressin dose) to treat shock for at least 4 hours at the time of enrollment; (5) cumulative SOFA score of at least 6; (6) and blood lactate level exceeding 18 mg/dL |
Human Exclusion Criteria: | . Patients were excluded if they were pregnant or breastfeeding or had any of the following characteristics: primary diagnosis other than sepsis, an established do-not-resuscitate status or advance directive restricting aggressive care, any history of seizures, known inborn error of metabolism, anticipated surgery that would interfere with a 12-hour infusion, active participation in another interventional trial, cardiopulmonary resuscitation before enrollment, known allergy to levocarnitine, active warfarin treatment, or severe immunocompromised state |
Select appropriate tab below to view additional metadata details:
NMR:
NMR ID: | NM000163 |
Analysis ID: | AN002253 |
Instrument Name: | Varian 11.74T |
Instrument Type: | FT-NMR |
NMR Experiment Type: | 1D-1H |
NMR Comments: | Arrayed for water saturation frequency and 90deg. pulse width for each sample. Varian (now Agilent, Inc., Santa Clara, CA) 11.74 Tesla (500 MHz) NMR spectrometer |
Spectrometer Frequency: | 500 MHz |
NMR Probe: | 5-mm Agilent “One-probe |
NMR Solvent: | D20 |
NMR Tube Size: | 5mm |
Shimming Method: | Auto shim (gradient shimming) |
Pulse Sequence: | 1 H,1 H-NOESY (commonly referred to as a 1D-NOESY or METNOESY) |
Water Suppression: | saturation at 80 Hz induced field strength |
Pulse Width: | ~5.5ms, arrayed for in each sample |
Temperature: | 25 |
Number Of Scans: | 32 |