Summary of Study ST000450
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000348. The data can be accessed directly via it's Project DOI: 10.21228/M82K58 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000450 |
Study Title | Metabolic features of chronic fatigue syndrome |
Study Type | Plasma metabolomic profiling |
Study Summary | This targeted metabolomic analysis was performed on plasma samples from 39 normal controls (n=18 men and 21 women) and 45 subjects ((n = 22 men and 23 women) who met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria. |
Institute | University of California, San Diego |
Department | The Mitochondrial and Metabolic Disease Center |
Last Name | Naviaux |
First Name | Robert |
Address | 214 Dikinson Street, CTF-C102, San Diego, CA, 92103 |
maviaux@ucsd.edu | |
Phone | 619-993-2904 |
Submit Date | 2016-08-11 |
Num Groups | 2 groups for men (control and CFS) and 2 groups for women (control and CFS) |
Total Subjects | 84 |
Raw Data File Type(s) | wiff |
Analysis Type Detail | LC-MS |
Release Date | 2016-12-22 |
Release Version | 1 |
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Project:
Project ID: | PR000348 |
Project DOI: | doi: 10.21228/M82K58 |
Project Title: | Metabolic features of chronic fatigue |
Project Type: | Human plasma |
Project Summary: | More than 2 million people in the United States have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain insights into the biology of CFS. We studied a total of 84 subjects using these methods. Forty-five subjects (n = 22 men and 23 women) met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria. We targeted 612 metabolites in plasma from 63 biochemical pathways by hydrophilic interaction liquid chromatography, electrospray ionization, and tandem mass spectrometry in a single-injection method. Our data show that despite the heterogeneity of factors leading to CFS, the cellular metabolic response in patients was homogeneous, statistically robust, and chemically similar to the evolutionarily conserved persistence response to environmental stress known as dauer. |
Institute: | University of California, San Diego |
Department: | The Mitochondrial and Metabolic Disease Center |
Last Name: | Naviaux |
First Name: | Robert |
Address: | 214 Dikinson Street, CTF-C102, San Diego, CA, 92103 |
Email: | maviaux@ucsd.edu |
Phone: | (619) 993-2904 |
Funding Source: | UCSD Christini Fund,The Wright Family Foundation,The Lennox Foundation, The It Takes Guts Foundation, The UCSD Mitochondrial Disease Research Fund |
Publications: | PNAS publication |