Summary of Study ST001346
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000917. The data can be accessed directly via it's Project DOI: 10.21228/M8568J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001346 |
Study Title | Metabolomic changes in mouse liver on a protein restricted diet (part-I) |
Study Summary | The data provided here are in support of the publication “Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution” Yann W. Yap et al. Nature Communications 2020 (accepted for publication). Here we provide untargeted metabolomics LC-MS data from liver from C57Bl/6NCrl mice fed a diet in which dietary protein was restricted and corresponding unrestricted controls. Specifically, liver from animals on a low-protein diet following a week of diet adaptation and correspond controls with n = 5 for each group. |
Institute | Monash University |
Department | Department of Biochemistry and Molecular Biology |
Laboratory | Nutrient Metabolism and Signalling Laboratory |
Last Name | Rose |
First Name | Adam |
Address | Monash University, Clayton Campus, 23 Innovation Walk, Clayton, Victoria, 3800, Australia |
adam.rose@monash.edu | |
Phone | +61 3 99029340 |
Submit Date | 2020-04-01 |
Num Groups | 2 |
Total Subjects | 10 |
Num Males | 10 |
Study Comments | Study 1 of 3 for this project |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2020-07-20 |
Release Version | 1 |
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Project:
Project ID: | PR000917 |
Project DOI: | doi: 10.21228/M8568J |
Project Title: | Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution |
Project Summary: | The data provided here are in support of the publication “Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution” Yann W. Yap et al. Nature Communications 2020 (accepted for publication). Here we provide untargeted metabolomics LC-MS data from liver and plasma from mice fed a diet in which dietary protein was restricted and corresponding unrestricted controls. Specifically, part 1 and 2 correspond to liver and plasma from the hepatic portal vein respectively from animals on a low-protein diet following a week of diet adaptation and correspond controls with n = 5 for each group. Part 3 of the data presented here corresponds to liver from mice subject to a 3wk treatment with diets either containing 18% digestible energy from amino acids or a diet with restricted amounts of threonine and following prior treatments with adeno-associated viruses to transduce the liver to express yeast threonine biosynthetic enzymes (AAV-yTHR1+THR4) or a negative control (AAV-GFP). n= 6 individual mice per group. |
Institute: | Monash University |
Department: | Department of Biochemistry and Molecular Biology |
Laboratory: | Nutrient Metabolism and Signalling Laboratory |
Last Name: | Rose |
First Name: | Adam |
Address: | Monash University, Clayton Campus, 23 Innovation Walk, Clayton, Victoria, 3800, Australia |
Email: | adam.rose@monash.edu |
Phone: | +61 3 99029340 |