Summary of Study ST002285
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001465. The data can be accessed directly via it's Project DOI: 10.21228/M8C12D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002285 |
| Study Title | Multiplatform mass spectrometry-based analysis of Leishmania donovani infected macrophages at different time points after infection |
| Study Type | Mutiplatform mass spectrometry-based metabolomics, time course experiment |
| Study Summary | The project aims to measure targeted and non-targeted metabolite data of intracellular extracts of uninfected and Leishmania-donovani infected macrophages at 0, 12, 36 and 72 hours post infection using a multiplatform mass spectrometry approach combining CE-TOF/MS (polar metabolites), LC-QTOF/MS (non-polar metabolites) and LC-QqQ/MS (polar metabolites) to characterize the dynamics of metabolic alterations ocurring in the human macrophage upon L. donovani infection. |
| Institute | Universidad CEU San Pablo |
| Department | Chemistry and Biochemistry |
| Laboratory | Centre for Metabolomics and Bioanalysis (CEMBIO) |
| Last Name | Fernández García |
| First Name | Miguel |
| Address | Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte. España |
| mig.fernandez.ce@ceindo.ceu.es | |
| Phone | +0034690090778 |
| Submit Date | 2022-07-01 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-07-01 |
| Release Version | 1 |
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Project:
| Project ID: | PR001465 |
| Project DOI: | doi: 10.21228/M8C12D |
| Project Title: | Immunometabolic Networks in the Regulation of Visceral Leishmaniasis |
| Project Summary: | Despite a wealth of information about the mechanisms underlying immunity to disease following Leishmania infection, the correlates of protection in human leishmaniasis remain poorly defined. In that sense, a complete understanding of Leishmania biology and host-pathogen interactions is mandatory to fully recognize the molecular and cellular foundations of leishmaniasis pathogenesis. Recent studies have been demonstrating how innate cell metabolism associates to the development of resistance towards infection. As the causality in the immunometabolic connections remains untested, we propose to employ an integrative approach aiming at mapping the Leishmania-induced shifts in metabolic networks in macrophages and neutrophils, deciphering the molecular mechanisms of the metabolic shifts and establishing its causal relationship with the anti-leishmanial immune response mediated by these two types of cells. Dissecting these aspects is critical not only for an in-depth understanding of the biological mechanisms underlying Leishmania pathogenesis, but also to drive significant advances in the development of novel diagnostic and immunotherapeutic approaches. |
| Institute: | University of Minho |
| Department: | School of Medicine |
| Laboratory: | Life and Health Sciences Research Institute (ICVS) |
| Last Name: | Fernandez |
| First Name: | Miguel |
| Address: | Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho |
| Email: | mig.fernandez.ce@ceindo.ceu.es |
| Phone: | 690090778 |
