Summary of Study ST002706
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001677. The data can be accessed directly via it's Project DOI: 10.21228/M8XQ5D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002706 |
| Study Title | Plasma metabolomics of Bmal1-KO and Bmal1-KO+AAV |
| Study Summary | Disruption of the circadian clock in skeletal muscle worsens local and systemic health, leading to decreased muscle strength, metabolic dysfunction, and aging-like phenotypes. Whole-body knockout mice that lack Bmal1, a key component of the molecular clock, display premature aging. Here, by using adeno-associated viruses, we rescued Bmal1 expression specifically in the skeletal muscle of Bmal1-KO mice and found that this improves their healthspan and lifespan. Plasma samples from 40-week-old KO and KO+AAV male mice were collected at ZT1 to characterize the systemic effects of muscle-specific expression of Bmal1. Overall, our findings highlight the critical role of skeletal muscle in systemic health. |
| Institute | University of Florida |
| Last Name | Esser |
| First Name | Karyn |
| Address | 1345 Center Drive, M552, Gainesville, Florida, 32610, USA |
| kaesser@ufl.edu | |
| Phone | 352-273-5728 |
| Submit Date | 2023-05-16 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-05-31 |
| Release Version | 1 |
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Project:
| Project ID: | PR001677 |
| Project DOI: | doi: 10.21228/M8XQ5D |
| Project Title: | Changes in the plasma metabolomics en in the muscle-specific rescue of Bmal1 |
| Project Summary: | This study examines the systemic effects of muscle-specific Bmal1 expression in the Bmal1-KO mouse model. We used an adeno-associated virus to rescue the expression of the clock gene Bmal1 in skeletal muscle of the Bmal1 KO. |
| Institute: | University of Florida |
| Department: | Department of Physiology and Aging |
| Last Name: | Esser |
| First Name: | Karyn |
| Address: | 1345 Center Drive, M552, Gainesville, Florida, 32610, USA |
| Email: | kaesser@ufl.edu |
| Phone: | 352-273-5728 |
