Summary of Study ST001855
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001170. The data can be accessed directly via it's Project DOI: 10.21228/M8G98C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001855 |
Study Title | The metabolomic resetting effect of FG4592 in AKI to CKD transition (Part 1) |
Study Summary | C57BL/6 mice were anesthetized using isoflurane. UIR was induced by clamping the right renal pedicle for 45 minutes and then releasing it to allow reperfusion, leaving the left kidney intact. Sham treated mice served as controls. Each mouse was located supine on a thermostatic pad (37 °C) to maintain its body temperature throughout the whole process. After 3 days of recovery, the mice received a daily intraperitoneal (i.p.) injection of FG4592 (10 mg/kg) or vehicle for 18 consecutive days. After treatment, the mice were sacrificed. Non-target metabolomics analysis was carried out using the kidney tissues of mice sacrificed at day 21 after UIR. |
Institute | Children's Hospital of Nanjing Medical University |
Last Name | Chen |
First Name | Weiyi |
Address | 72 Guangzhou Road, Nanjing 210008, P. R. of China |
chen.weiyi@qq.com | |
Phone | 0086-25-8311-7309 |
Submit Date | 2021-06-30 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2021-07-07 |
Release Version | 1 |
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Sample Preparation:
Sampleprep ID: | SP001938 |
Sampleprep Summary: | 20 mg of each tissue sample were homogenized with 0.6 mL of 2 chloro phenylalanine (4 ppm) containing methanol (−20 °C), centrifuged, and filtered through a 0.22-μm membrane |