Summary of Study ST003281
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002033. The data can be accessed directly via it's Project DOI: 10.21228/M8TN7J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003281 |
| Study Title | Phosphate availability conditions caspofungin tolerance, capsule attachment and titan cell formation in Cryptococcus neoformans |
| Study Type | Metabolomics and lipidomics |
| Study Summary | There is a pressing need for new antifungal drugs to treat invasive fungal diseases. Unfortunately, the echinocandin drugs that are fungicidal against other important fungal pathogens are ineffective against Cryptococcus neoformans, the causative agent of life-threatening meningoencephalitis in immunocompromised people. Contributing mechanisms for echinocandin tolerance are emerging with connections to calcineurin signaling, the cell wall, and membrane composition. In this context, we discovered that a defect in phosphate uptake impairs the tolerance of C. neoformans to the echinocandin caspofungin. |
| Institute | University of British Columbia |
| Department | Life Sciences Institute |
| Last Name | Alcazar Magana |
| First Name | Armando |
| Address | 2350 Health Sciences Mall |
| armando.alcazarmagana@ubc.ca | |
| Phone | 5416097172 |
| Submit Date | 2024-06-12 |
| Num Groups | 8 |
| Total Subjects | 28 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-06-28 |
| Release Version | 1 |
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Sample Preparation:
| Sampleprep ID: | SP003408 |
| Sampleprep Summary: | Lipid extraction was performed using a biphasic system of cold methanol, methyltert-butyl ether (MTBE), and H2O, as described with some modifications (Matyash, et al., 2008). |
